Glutamate synapse in developing brain

an integrative perspective beyond the silent state

Eric Hanse, Tomi Taira, Sari Lauri, Laurent Groc

Research output: Contribution to journalArticleScientificpeer-review

Abstract

"Cellular events underlying the establishment of glutamate transmission have been the focus of attention because appropriate wiring of developing neuronal networks is essential for adult brain functions. Although establishment of a synapse is a dynamic process requiring axonal and dendritic refinements, the functional interplay between pre- and postsynaptic signaling is often ignored. Here, we discuss recent data on pre- and postsynaptic plasticity of the glutamate synapse in the developing brain. The key aspect of the proposed model is that developing synapses are functionally labile in response to activity and this lability is counteracted by Hebbian activity. Both presynaptic and postsynaptic (loss of AMPA receptor signaling) mechanisms contribute to lability. Therefore, synapses in the developing brain maintain their capacity for functional AMPA signaling either by being presynaptically silent or by having participated in Hebbian activity; any synaptic activity outside this context leads instead to AMPA silencing and possible synaptic elimination."
Original languageEnglish
JournalTrends in Neurosciences
Volume32
Issue number10
Pages (from-to)532-537
Number of pages6
ISSN0166-2236
DOIs
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 311 Basic medicine
  • 118 Biological sciences
  • 515 Psychology

Cite this

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title = "Glutamate synapse in developing brain: an integrative perspective beyond the silent state",
abstract = "{"}Cellular events underlying the establishment of glutamate transmission have been the focus of attention because appropriate wiring of developing neuronal networks is essential for adult brain functions. Although establishment of a synapse is a dynamic process requiring axonal and dendritic refinements, the functional interplay between pre- and postsynaptic signaling is often ignored. Here, we discuss recent data on pre- and postsynaptic plasticity of the glutamate synapse in the developing brain. The key aspect of the proposed model is that developing synapses are functionally labile in response to activity and this lability is counteracted by Hebbian activity. Both presynaptic and postsynaptic (loss of AMPA receptor signaling) mechanisms contribute to lability. Therefore, synapses in the developing brain maintain their capacity for functional AMPA signaling either by being presynaptically silent or by having participated in Hebbian activity; any synaptic activity outside this context leads instead to AMPA silencing and possible synaptic elimination.{"}",
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Glutamate synapse in developing brain : an integrative perspective beyond the silent state. / Hanse, Eric; Taira, Tomi; Lauri, Sari; Groc, Laurent.

In: Trends in Neurosciences, Vol. 32, No. 10, 2009, p. 532-537.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Glutamate synapse in developing brain

T2 - an integrative perspective beyond the silent state

AU - Hanse, Eric

AU - Taira, Tomi

AU - Lauri, Sari

AU - Groc, Laurent

PY - 2009

Y1 - 2009

N2 - "Cellular events underlying the establishment of glutamate transmission have been the focus of attention because appropriate wiring of developing neuronal networks is essential for adult brain functions. Although establishment of a synapse is a dynamic process requiring axonal and dendritic refinements, the functional interplay between pre- and postsynaptic signaling is often ignored. Here, we discuss recent data on pre- and postsynaptic plasticity of the glutamate synapse in the developing brain. The key aspect of the proposed model is that developing synapses are functionally labile in response to activity and this lability is counteracted by Hebbian activity. Both presynaptic and postsynaptic (loss of AMPA receptor signaling) mechanisms contribute to lability. Therefore, synapses in the developing brain maintain their capacity for functional AMPA signaling either by being presynaptically silent or by having participated in Hebbian activity; any synaptic activity outside this context leads instead to AMPA silencing and possible synaptic elimination."

AB - "Cellular events underlying the establishment of glutamate transmission have been the focus of attention because appropriate wiring of developing neuronal networks is essential for adult brain functions. Although establishment of a synapse is a dynamic process requiring axonal and dendritic refinements, the functional interplay between pre- and postsynaptic signaling is often ignored. Here, we discuss recent data on pre- and postsynaptic plasticity of the glutamate synapse in the developing brain. The key aspect of the proposed model is that developing synapses are functionally labile in response to activity and this lability is counteracted by Hebbian activity. Both presynaptic and postsynaptic (loss of AMPA receptor signaling) mechanisms contribute to lability. Therefore, synapses in the developing brain maintain their capacity for functional AMPA signaling either by being presynaptically silent or by having participated in Hebbian activity; any synaptic activity outside this context leads instead to AMPA silencing and possible synaptic elimination."

KW - 311 Basic medicine

KW - 118 Biological sciences

KW - 515 Psychology

U2 - 10.1016/j.tins.2009.07.003

DO - 10.1016/j.tins.2009.07.003

M3 - Article

VL - 32

SP - 532

EP - 537

JO - Trends in Neurosciences

JF - Trends in Neurosciences

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ER -