Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes

Yuhao Fu, Qingyuan Dou, Kornelia Smalla, Yu Wang, Timothy A. Johnson, Kristian K. Brandt, Zhi Mei, Maoyuan Liao, Syed A. Hashsham, Andreas Schäffer, Hauke Smidt, Tong Zhang, Hui Li, Robert Stedtfeld, Hongjie Sheng, Benli Chai, Marko Virta, Xin Jiang, Fang Wang, Yong Guan ZhuJames M. Tiedje

Research output: Contribution to journalReview Articlepeer-review

Abstract

The emergence and rapid spread of antimicrobial resistance is of global public health concern. The gut microbiota harboring diverse commensal and opportunistic bacteria that can acquire resistance via horizontal and vertical gene transfers is considered an important reservoir and sink of antibiotic resistance genes (ARGs). In this review, we describe the reservoirs of gut ARGs and their dynamics in both animals and humans, use the One Health perspective to track the transmission of ARG-containing bacteria between humans, animals, and the environment, and assess the impact of antimicrobial resistance on human health and socioeconomic development. The gut resistome can evolve in an environment subject to various selective pressures, including antibiotic administration and environmental and lifestyle factors (e.g., diet, age, gender, and living conditions), and interventions through probiotics. Strategies to reduce the abundance of clinically relevant antibiotic-resistant bacteria and their resistance determinants in various environmental niches are needed to ensure the mitigation of acquired antibiotic resistance. With the help of effective measures taken at the national, local, personal, and intestinal management, it will also result in preventing or minimizing the spread of infectious diseases. This review aims to improve our understanding of the correlations between intestinal microbiota and antimicrobial resistance and provide a basis for the development of management strategies to mitigate the antimicrobial resistance crisis.

Original languageEnglish
JournalmLife
Volume2
Issue number4
Pages (from-to)350-364
Number of pages15
ISSN2097-1699
DOIs
Publication statusPublished - Dec 2023
MoE publication typeA2 Review article in a scientific journal

Bibliographical note

Publisher Copyright:
© 2023 The Authors. mLife published by John Wiley & Sons Australia, Ltd on behalf of Institute of Microbiology, Chinese Academy of Sciences.

Fields of Science

  • antibiotic
  • antimicrobial resistance
  • gut microbiota
  • modulatory strategies
  • One Health
  • 11832 Microbiology and virology

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