GWAS of Second‐Generation Antihistamine Use: Locus Specificity and Highlighted Signalling Pathways

Mari Niemi; S Ruotsalainen; Elmo Christian Saarentaus; Iida Vähätalo; FinnGen Project; Inna Starskaia; T Harju; M Pelkonen; Thijs Feuth; Paula Maria Kauppi; Jukka Partanen; Riitta Lahesmaa; Vesa P. Hytönen; Aarno Palotie; Hannu Kankaanranta; Tarja Laitinen

doi:10.1111/cea.70382

GWAS of Second‐Generation Antihistamine Use: Locus Specificity and Highlighted Signalling Pathways

Mari Niemi
, S Ruotsalainen
, Elmo Christian Saarentaus
, Iida Vähätalo
, FinnGen Project
, Inna Starskaia
, T Harju
, M Pelkonen
, Thijs Feuth
, Paula Maria Kauppi
, Jukka Partanen
, Riitta Lahesmaa
, Vesa P. Hytönen
, Aarno Palotie
, Hannu Kankaanranta
, Tarja Laitinen

Research output: Contribution to journal › Letter › Scientific

Abstract

Summary Four of 67 loci were specific to antihistamine use; most overlapped inflammatory disease susceptibility. Genetic variation enriched in IL‐2 cytokine, JAK–STAT pathway genes shared by allergy and autoimmunity.

Original language	English
Journal	Clinical and Experimental Allergy
Number of pages	3
ISSN	0954-7894
DOIs	https://doi.org/10.1111/cea.70382
Publication status	Published - 2 Jul 2026
MoE publication type	B1 Journal article

Fields of Science

Asthma and respiratory diseases
3121 General medicine, internal medicine and other clinical medicine

Access to Document

10.1111/cea.70382Licence: CC BY

Cite this

Niemi, M., Ruotsalainen, S., Saarentaus, E. C., Vähätalo, I., Project, F., Starskaia, I., Harju, T., Pelkonen, M., Feuth, T., Kauppi, P. M., Partanen, J., Lahesmaa, R., Hytönen, V. P., Palotie, A., Kankaanranta, H., & Laitinen, T. (2026). GWAS of Second‐Generation Antihistamine Use: Locus Specificity and Highlighted Signalling Pathways. Clinical and Experimental Allergy. https://doi.org/10.1111/cea.70382

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abstract = "Summary Four of 67 loci were specific to antihistamine use; most overlapped inflammatory disease susceptibility. Genetic variation enriched in IL‐2 cytokine, JAK–STAT pathway genes shared by allergy and autoimmunity.",

keywords = "Asthma and respiratory diseases, Asthma and respiratory diseases, 3121 General medicine, internal medicine and other clinical medicine",

author = "Mari Niemi and S Ruotsalainen and Saarentaus, \{Elmo Christian\} and Iida V{\"a}h{\"a}talo and FinnGen Project and Inna Starskaia and T Harju and M Pelkonen and Thijs Feuth and Kauppi, \{Paula Maria\} and Jukka Partanen and Riitta Lahesmaa and Hyt{\"o}nen, \{Vesa P.\} and Aarno Palotie and Hannu Kankaanranta and Tarja Laitinen",

year = "2026",

month = jul,

day = "2",

doi = "10.1111/cea.70382",

language = "English",

journal = "Clinical and Experimental Allergy",

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Niemi, M, Ruotsalainen, S, Saarentaus, EC, Vähätalo, I, Project, F, Starskaia, I, Harju, T, Pelkonen, M, Feuth, T, Kauppi, PM, Partanen, J, Lahesmaa, R, Hytönen, VP, Palotie, A, Kankaanranta, H & Laitinen, T 2026, 'GWAS of Second‐Generation Antihistamine Use: Locus Specificity and Highlighted Signalling Pathways', Clinical and Experimental Allergy. https://doi.org/10.1111/cea.70382

TY - JOUR

T1 - GWAS of Second‐Generation Antihistamine Use

T2 - Locus Specificity and Highlighted Signalling Pathways

AU - Niemi, Mari

AU - Ruotsalainen, S

AU - Saarentaus, Elmo Christian

AU - Vähätalo, Iida

AU - Project, FinnGen

AU - Starskaia, Inna

AU - Harju, T

AU - Pelkonen, M

AU - Feuth, Thijs

AU - Kauppi, Paula Maria

AU - Partanen, Jukka

AU - Lahesmaa, Riitta

AU - Hytönen, Vesa P.

AU - Palotie, Aarno

AU - Kankaanranta, Hannu

AU - Laitinen, Tarja

PY - 2026/7/2

Y1 - 2026/7/2

N2 - Summary Four of 67 loci were specific to antihistamine use; most overlapped inflammatory disease susceptibility. Genetic variation enriched in IL‐2 cytokine, JAK–STAT pathway genes shared by allergy and autoimmunity.

AB - Summary Four of 67 loci were specific to antihistamine use; most overlapped inflammatory disease susceptibility. Genetic variation enriched in IL‐2 cytokine, JAK–STAT pathway genes shared by allergy and autoimmunity.

KW - Asthma and respiratory diseases

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1111/cea.70382

DO - 10.1111/cea.70382

M3 - Letter

C2 - 42390178

SN - 0954-7894

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

ER -