Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice

Eleonora Leggiero, Giuseppe Labruna, Laura Iaffaldano, Barbara Lombardo, Adelaide Greco, Dario Fiorenza, Matteo Gramanzini, Donatella Montanaro, Alfonso Baldi, Vincenzo Cerullo, Lucia Sacchetti, Lucio Pastore

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalGene Therapy (Basingstoke)
Volume26
Issue number3-4
Pages (from-to)121-130
Number of pages10
ISSN0969-7128
DOIs
Publication statusPublished - Apr 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • A-I
  • FAMILIAL HYPERCHOLESTEROLEMIA
  • FUNCTIONAL-EVALUATION
  • IMMUNE-RESPONSES
  • THERAPEUTIC TOOL
  • FUSION PROTEIN
  • AAV-VECTORS
  • MOUSE MODEL
  • EXPRESSION
  • LIVER
  • 1182 Biochemistry, cell and molecular biology
  • 1183 Plant biology, microbiology, virology
  • 1184 Genetics, developmental biology, physiology

Cite this

Leggiero, Eleonora ; Labruna, Giuseppe ; Iaffaldano, Laura ; Lombardo, Barbara ; Greco, Adelaide ; Fiorenza, Dario ; Gramanzini, Matteo ; Montanaro, Donatella ; Baldi, Alfonso ; Cerullo, Vincenzo ; Sacchetti, Lucia ; Pastore, Lucio. / Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice. In: Gene Therapy (Basingstoke). 2019 ; Vol. 26, No. 3-4. pp. 121-130.
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title = "Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice",
keywords = "A-I, FAMILIAL HYPERCHOLESTEROLEMIA, FUNCTIONAL-EVALUATION, IMMUNE-RESPONSES, THERAPEUTIC TOOL, FUSION PROTEIN, AAV-VECTORS, MOUSE MODEL, EXPRESSION, LIVER, 1182 Biochemistry, cell and molecular biology, 1183 Plant biology, microbiology, virology, 1184 Genetics, developmental biology, physiology",
author = "Eleonora Leggiero and Giuseppe Labruna and Laura Iaffaldano and Barbara Lombardo and Adelaide Greco and Dario Fiorenza and Matteo Gramanzini and Donatella Montanaro and Alfonso Baldi and Vincenzo Cerullo and Lucia Sacchetti and Lucio Pastore",
year = "2019",
month = "4",
doi = "10.1038/s41434-019-0061-z",
language = "English",
volume = "26",
pages = "121--130",
journal = "Gene Therapy (Basingstoke)",
issn = "0969-7128",
publisher = "Nature Publishing Group",
number = "3-4",

}

Leggiero, E, Labruna, G, Iaffaldano, L, Lombardo, B, Greco, A, Fiorenza, D, Gramanzini, M, Montanaro, D, Baldi, A, Cerullo, V, Sacchetti, L & Pastore, L 2019, 'Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice' Gene Therapy (Basingstoke), vol. 26, no. 3-4, pp. 121-130. https://doi.org/10.1038/s41434-019-0061-z

Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice. / Leggiero, Eleonora; Labruna, Giuseppe; Iaffaldano, Laura; Lombardo, Barbara; Greco, Adelaide; Fiorenza, Dario; Gramanzini, Matteo; Montanaro, Donatella; Baldi, Alfonso; Cerullo, Vincenzo; Sacchetti, Lucia; Pastore, Lucio.

In: Gene Therapy (Basingstoke), Vol. 26, No. 3-4, 04.2019, p. 121-130.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice

AU - Leggiero, Eleonora

AU - Labruna, Giuseppe

AU - Iaffaldano, Laura

AU - Lombardo, Barbara

AU - Greco, Adelaide

AU - Fiorenza, Dario

AU - Gramanzini, Matteo

AU - Montanaro, Donatella

AU - Baldi, Alfonso

AU - Cerullo, Vincenzo

AU - Sacchetti, Lucia

AU - Pastore, Lucio

PY - 2019/4

Y1 - 2019/4

KW - A-I

KW - FAMILIAL HYPERCHOLESTEROLEMIA

KW - FUNCTIONAL-EVALUATION

KW - IMMUNE-RESPONSES

KW - THERAPEUTIC TOOL

KW - FUSION PROTEIN

KW - AAV-VECTORS

KW - MOUSE MODEL

KW - EXPRESSION

KW - LIVER

KW - 1182 Biochemistry, cell and molecular biology

KW - 1183 Plant biology, microbiology, virology

KW - 1184 Genetics, developmental biology, physiology

U2 - 10.1038/s41434-019-0061-z

DO - 10.1038/s41434-019-0061-z

M3 - Article

VL - 26

SP - 121

EP - 130

JO - Gene Therapy (Basingstoke)

JF - Gene Therapy (Basingstoke)

SN - 0969-7128

IS - 3-4

ER -