Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation

Katariina Nurmi, Ilona Kareinen, Juhani Virkanen, Kristiina Rajamaki, Vesa-Petteri Kouri, Kirsi Vaali, Anna-Liisa Levonen, Nanna Fyhrquist, Sampsa Matikainen, Petri T. Kovanen, Kari K. Eklund

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of innate immunity
Volume9
Issue number1
Pages (from-to)65-82
Number of pages18
ISSN1662-811X
DOIs
Publication statusPublished - 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Inflannmasome
  • Autophagy
  • Macrophage
  • Hemin
  • Cobalt protoporphyrin
  • Heme oxygenase-1
  • LUNG INJURY
  • CATHEPSIN-B
  • OXYGENASE-1
  • LIPOPOLYSACCHARIDE
  • IL-1-BETA
  • CRYSTALS
  • MICE
  • EXPRESSION
  • IMMUNITY
  • DISEASES
  • 3111 Biomedicine

Cite this