Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy

A Novel Mechanism of Inflammasome Regulation

Katariina Nurmi, Ilona Kareinen, Juhani Virkanen, Kristiina Rajamaki, Vesa-Petteri Kouri, Kirsi Vaali, Anna-Liisa Levonen, Nanna Fyhrquist, Sampsa Matikainen, Petri T. Kovanen, Kari K. Eklund

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of innate immunity
Volume9
Issue number1
Pages (from-to)65-82
Number of pages18
ISSN1662-811X
DOIs
Publication statusPublished - 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Inflannmasome
  • Autophagy
  • Macrophage
  • Hemin
  • Cobalt protoporphyrin
  • Heme oxygenase-1
  • LUNG INJURY
  • CATHEPSIN-B
  • OXYGENASE-1
  • LIPOPOLYSACCHARIDE
  • IL-1-BETA
  • CRYSTALS
  • MICE
  • EXPRESSION
  • IMMUNITY
  • DISEASES
  • 3111 Biomedicine

Cite this

@article{342416f603a34f85b4bdfd8dcb0d92fe,
title = "Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation",
keywords = "Inflannmasome, Autophagy, Macrophage, Hemin, Cobalt protoporphyrin, Heme oxygenase-1, LUNG INJURY, CATHEPSIN-B, OXYGENASE-1, LIPOPOLYSACCHARIDE, IL-1-BETA, CRYSTALS, MICE, EXPRESSION, IMMUNITY, DISEASES, 3111 Biomedicine",
author = "Katariina Nurmi and Ilona Kareinen and Juhani Virkanen and Kristiina Rajamaki and Vesa-Petteri Kouri and Kirsi Vaali and Anna-Liisa Levonen and Nanna Fyhrquist and Sampsa Matikainen and Kovanen, {Petri T.} and Eklund, {Kari K.}",
year = "2017",
doi = "10.1159/000448894",
language = "English",
volume = "9",
pages = "65--82",
journal = "Journal of innate immunity",
issn = "1662-811X",
publisher = "Karger",
number = "1",

}

Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy : A Novel Mechanism of Inflammasome Regulation. / Nurmi, Katariina; Kareinen, Ilona; Virkanen, Juhani; Rajamaki, Kristiina; Kouri, Vesa-Petteri; Vaali, Kirsi; Levonen, Anna-Liisa; Fyhrquist, Nanna; Matikainen, Sampsa; Kovanen, Petri T.; Eklund, Kari K.

In: Journal of innate immunity, Vol. 9, No. 1, 2017, p. 65-82.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy

T2 - A Novel Mechanism of Inflammasome Regulation

AU - Nurmi, Katariina

AU - Kareinen, Ilona

AU - Virkanen, Juhani

AU - Rajamaki, Kristiina

AU - Kouri, Vesa-Petteri

AU - Vaali, Kirsi

AU - Levonen, Anna-Liisa

AU - Fyhrquist, Nanna

AU - Matikainen, Sampsa

AU - Kovanen, Petri T.

AU - Eklund, Kari K.

PY - 2017

Y1 - 2017

KW - Inflannmasome

KW - Autophagy

KW - Macrophage

KW - Hemin

KW - Cobalt protoporphyrin

KW - Heme oxygenase-1

KW - LUNG INJURY

KW - CATHEPSIN-B

KW - OXYGENASE-1

KW - LIPOPOLYSACCHARIDE

KW - IL-1-BETA

KW - CRYSTALS

KW - MICE

KW - EXPRESSION

KW - IMMUNITY

KW - DISEASES

KW - 3111 Biomedicine

U2 - 10.1159/000448894

DO - 10.1159/000448894

M3 - Article

VL - 9

SP - 65

EP - 82

JO - Journal of innate immunity

JF - Journal of innate immunity

SN - 1662-811X

IS - 1

ER -