Hepsin regulates TGF beta signaling via fibronectin proteolysis

Denis Belitskin; Shishir M. Pant; Pauliina Munne; Ilida Suleymanova; Kati Belitskina; Hanna Ala-Hongisto; Johanna Englund; Tiina Raatikainen; Olga Klezovitch; Valeri Vasioukhin; Shuo Li; Qingyu Wu; Outi Monni; Satu Kuure; Pirjo Laakkonen; Jeroen Pouwels; Topi A. Tervonen; Juha Klefström

doi:10.15252/embr.202152532

Hepsin regulates TGF beta signaling via fibronectin proteolysis

Denis Belitskin, Shishir M. Pant, Pauliina Munne, Ilida Suleymanova, Kati Belitskina, Hanna Ala-Hongisto, Johanna Englund, Tiina Raatikainen, Olga Klezovitch, Valeri Vasioukhin, Shuo Li, Qingyu Wu, Outi Monni, Satu Kuure, Pirjo Laakkonen, Jeroen Pouwels, Topi A. Tervonen, Juha Klefström

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	52532
Journal	EMBO Reports
Volume	22
Issue number	11
Number of pages	16
ISSN	1469-221X
DOIs	https://doi.org/10.15252/embr.202152532
Publication status	Published - 4 Nov 2021
MoE publication type	A1 Journal article-refereed

Fields of Science

breast cancer
fibronectin
hepsin
TGF beta
tumor microenvironment
GROWTH-FACTOR-BETA
TRANSMEMBRANE SERINE-PROTEASE
PROSTATE-CANCER
GENE-EXPRESSION
MAMMARY-GLAND
PLASMINOGEN-ACTIVATOR
MICE DEFICIENT
OVARIAN-CANCER
CELL
INVASION
3111 Biomedicine

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10.15252/embr.202152532Licence: CC BY-NC-ND

HepsinFinal published version, 2.41 MBLicence: CC BY-NC-ND

Cite this

Belitskin, D., Pant, S. M., Munne, P., Suleymanova, I., Belitskina, K., Ala-Hongisto, H., Englund, J., Raatikainen, T., Klezovitch, O., Vasioukhin, V., Li, S., Wu, Q., Monni, O., Kuure, S., Laakkonen, P., Pouwels, J., Tervonen, T. A., & Klefström, J. (2021). Hepsin regulates TGF beta signaling via fibronectin proteolysis. EMBO Reports, 22(11), Article 52532. https://doi.org/10.15252/embr.202152532

@article{40e47d7a86fc4328831de05657d78283,

title = "Hepsin regulates TGF beta signaling via fibronectin proteolysis",

keywords = "breast cancer, fibronectin, hepsin, TGF beta, tumor microenvironment, GROWTH-FACTOR-BETA, TRANSMEMBRANE SERINE-PROTEASE, PROSTATE-CANCER, GENE-EXPRESSION, MAMMARY-GLAND, PLASMINOGEN-ACTIVATOR, MICE DEFICIENT, OVARIAN-CANCER, CELL, INVASION, 3111 Biomedicine",

author = "Denis Belitskin and Pant, {Shishir M.} and Pauliina Munne and Ilida Suleymanova and Kati Belitskina and Hanna Ala-Hongisto and Johanna Englund and Tiina Raatikainen and Olga Klezovitch and Valeri Vasioukhin and Shuo Li and Qingyu Wu and Outi Monni and Satu Kuure and Pirjo Laakkonen and Jeroen Pouwels and Tervonen, {Topi A.} and Juha Klefstr{\"o}m",

year = "2021",

month = nov,

day = "4",

doi = "10.15252/embr.202152532",

language = "English",

volume = "22",

journal = "EMBO Reports",

issn = "1469-221X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "11",

}

Belitskin, D, Pant, SM, Munne, P , Suleymanova, I, Belitskina, K, Ala-Hongisto, H, Englund, J, Raatikainen, T, Klezovitch, O, Vasioukhin, V, Li, S, Wu, Q, Monni, O , Kuure, S , Laakkonen, P , Pouwels, J , Tervonen, TA & Klefström, J 2021, 'Hepsin regulates TGF beta signaling via fibronectin proteolysis', EMBO Reports, vol. 22, no. 11, 52532. https://doi.org/10.15252/embr.202152532

TY - JOUR

T1 - Hepsin regulates TGF beta signaling via fibronectin proteolysis

AU - Belitskin, Denis

AU - Pant, Shishir M.

AU - Munne, Pauliina

AU - Suleymanova, Ilida

AU - Belitskina, Kati

AU - Ala-Hongisto, Hanna

AU - Englund, Johanna

AU - Raatikainen, Tiina

AU - Klezovitch, Olga

AU - Vasioukhin, Valeri

AU - Li, Shuo

AU - Wu, Qingyu

AU - Monni, Outi

AU - Kuure, Satu

AU - Laakkonen, Pirjo

AU - Pouwels, Jeroen

AU - Tervonen, Topi A.

AU - Klefström, Juha

PY - 2021/11/4

Y1 - 2021/11/4

KW - breast cancer

KW - fibronectin

KW - hepsin

KW - TGF beta

KW - tumor microenvironment

KW - GROWTH-FACTOR-BETA

KW - TRANSMEMBRANE SERINE-PROTEASE

KW - PROSTATE-CANCER

KW - GENE-EXPRESSION

KW - MAMMARY-GLAND

KW - PLASMINOGEN-ACTIVATOR

KW - MICE DEFICIENT

KW - OVARIAN-CANCER

KW - CELL

KW - INVASION

KW - 3111 Biomedicine

U2 - 10.15252/embr.202152532

DO - 10.15252/embr.202152532

M3 - Article

SN - 1469-221X

VL - 22

JO - EMBO Reports

JF - EMBO Reports

IS - 11

M1 - 52532

ER -