Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine

Wei Li, Yunzhan Li, Zehua Liu, Nattha Kerdsakundee, Ming Zhang, Feng Zhang, Xueyan Liu, Tomás Bauleth-Ramos, Ermei Mäkilä, Marianna Kemell, Yaping Ding, Bruno Sarmento, Ruedeekorn Wiwattanapatapee, Jarno Salonen, Hongbo Zhang, Jouni T. Hirvonen, Dongfei Liu, Xianming Deng, Hélder A. Santos

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Orally administrable drug delivery vehicles are developed to manage incurable inflammatory bowel disease (IBD), however, their therapeutic outcomes are compromised by the side effects of systemic drug exposure. Herein, we use hyaluronic acid functionalized porous silicon nanoparticle to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured (nano-in-nano-in-micro) vehicle with programmed properties to fully and sequentially overcome the multiple obstacles for efficiently delivering drugs locally to inflamed sites of intestine. After oral administration, the pH-responsive matrix protects the embedded hybrid nanoparticles containing drug loaded hydrogels against the spatially variable physiological environments of the gastrointestinal tract until they reach the inflamed sites of intestine, preventing premature drug release. The negatively charged hybrid nanoparticles selectively target the inflamed sites of intestine, and gradually release drug in response to the microenvironment of inflamed intestine. Overall, the developed hierarchical structured and programmed vehicles load, protect, transport and release drugs locally to inflamed sites of intestine, contributing to superior therapeutic outcomes. Such strategy could also inspire the development of numerous hierarchical structured vehicles by other porous nanoparticles and stimuli-responsive materials for the local delivery of various drugs to treat plenty of inflammatory gastrointestinal diseases, including IBD, gastrointestinal cancers and viral infections.
Original languageEnglish
JournalBiomaterials
Volume185
Pages (from-to)322-332
Number of pages11
ISSN0142-9612
DOIs
Publication statusPublished - Dec 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 317 Pharmacy
  • 318 Medical biotechnology
  • Porous silicon
  • Hybrid nanoparticle
  • Stimuli responsive
  • Targeting
  • Drug delivery
  • INFLAMMATORY-BOWEL-DISEASE
  • MESOPOROUS SILICA NANOPARTICLES
  • IN-VITRO MODEL
  • EXPERIMENTAL COLITIS
  • CHARGED LIPOSOMES
  • COLONIC-MUCOSA
  • THERAPY
  • SIRNA
  • BIOCOMPATIBILITY

Cite this

Li, Wei ; Li, Yunzhan ; Liu, Zehua ; Kerdsakundee, Nattha ; Zhang, Ming ; Zhang, Feng ; Liu, Xueyan ; Bauleth-Ramos, Tomás ; Mäkilä, Ermei ; Kemell, Marianna ; Ding, Yaping ; Sarmento, Bruno ; Wiwattanapatapee, Ruedeekorn ; Salonen, Jarno ; Zhang, Hongbo ; Hirvonen, Jouni T. ; Liu, Dongfei ; Deng, Xianming ; Santos, Hélder A. / Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine. In: Biomaterials. 2018 ; Vol. 185. pp. 322-332.
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title = "Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine",
abstract = "Orally administrable drug delivery vehicles are developed to manage incurable inflammatory bowel disease (IBD), however, their therapeutic outcomes are compromised by the side effects of systemic drug exposure. Herein, we use hyaluronic acid functionalized porous silicon nanoparticle to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured (nano-in-nano-in-micro) vehicle with programmed properties to fully and sequentially overcome the multiple obstacles for efficiently delivering drugs locally to inflamed sites of intestine. After oral administration, the pH-responsive matrix protects the embedded hybrid nanoparticles containing drug loaded hydrogels against the spatially variable physiological environments of the gastrointestinal tract until they reach the inflamed sites of intestine, preventing premature drug release. The negatively charged hybrid nanoparticles selectively target the inflamed sites of intestine, and gradually release drug in response to the microenvironment of inflamed intestine. Overall, the developed hierarchical structured and programmed vehicles load, protect, transport and release drugs locally to inflamed sites of intestine, contributing to superior therapeutic outcomes. Such strategy could also inspire the development of numerous hierarchical structured vehicles by other porous nanoparticles and stimuli-responsive materials for the local delivery of various drugs to treat plenty of inflammatory gastrointestinal diseases, including IBD, gastrointestinal cancers and viral infections.",
keywords = "317 Pharmacy, 318 Medical biotechnology, Porous silicon, Hybrid nanoparticle, Stimuli responsive, Targeting, Drug delivery, INFLAMMATORY-BOWEL-DISEASE, MESOPOROUS SILICA NANOPARTICLES, IN-VITRO MODEL, EXPERIMENTAL COLITIS, CHARGED LIPOSOMES, COLONIC-MUCOSA, THERAPY, SIRNA, BIOCOMPATIBILITY",
author = "Wei Li and Yunzhan Li and Zehua Liu and Nattha Kerdsakundee and Ming Zhang and Feng Zhang and Xueyan Liu and Tom{\'a}s Bauleth-Ramos and Ermei M{\"a}kil{\"a} and Marianna Kemell and Yaping Ding and Bruno Sarmento and Ruedeekorn Wiwattanapatapee and Jarno Salonen and Hongbo Zhang and Hirvonen, {Jouni T.} and Dongfei Liu and Xianming Deng and Santos, {H{\'e}lder A.}",
year = "2018",
month = "12",
doi = "10.1016/j.biomaterials.2018.09.024",
language = "English",
volume = "185",
pages = "322--332",
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issn = "0142-9612",
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Li, W, Li, Y, Liu, Z, Kerdsakundee, N, Zhang, M, Zhang, F, Liu, X, Bauleth-Ramos, T, Mäkilä, E, Kemell, M, Ding, Y, Sarmento, B, Wiwattanapatapee, R, Salonen, J, Zhang, H, Hirvonen, JT, Liu, D, Deng, X & Santos, HA 2018, 'Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine' Biomaterials, vol. 185, pp. 322-332. https://doi.org/10.1016/j.biomaterials.2018.09.024

Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine. / Li, Wei; Li, Yunzhan; Liu, Zehua; Kerdsakundee, Nattha ; Zhang, Ming; Zhang, Feng; Liu, Xueyan; Bauleth-Ramos, Tomás ; Mäkilä, Ermei; Kemell, Marianna; Ding, Yaping; Sarmento, Bruno; Wiwattanapatapee, Ruedeekorn ; Salonen, Jarno; Zhang, Hongbo; Hirvonen, Jouni T.; Liu, Dongfei; Deng, Xianming ; Santos, Hélder A.

In: Biomaterials, Vol. 185, 12.2018, p. 322-332.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine

AU - Li, Wei

AU - Li, Yunzhan

AU - Liu, Zehua

AU - Kerdsakundee, Nattha

AU - Zhang, Ming

AU - Zhang, Feng

AU - Liu, Xueyan

AU - Bauleth-Ramos, Tomás

AU - Mäkilä, Ermei

AU - Kemell, Marianna

AU - Ding, Yaping

AU - Sarmento, Bruno

AU - Wiwattanapatapee, Ruedeekorn

AU - Salonen, Jarno

AU - Zhang, Hongbo

AU - Hirvonen, Jouni T.

AU - Liu, Dongfei

AU - Deng, Xianming

AU - Santos, Hélder A.

PY - 2018/12

Y1 - 2018/12

N2 - Orally administrable drug delivery vehicles are developed to manage incurable inflammatory bowel disease (IBD), however, their therapeutic outcomes are compromised by the side effects of systemic drug exposure. Herein, we use hyaluronic acid functionalized porous silicon nanoparticle to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured (nano-in-nano-in-micro) vehicle with programmed properties to fully and sequentially overcome the multiple obstacles for efficiently delivering drugs locally to inflamed sites of intestine. After oral administration, the pH-responsive matrix protects the embedded hybrid nanoparticles containing drug loaded hydrogels against the spatially variable physiological environments of the gastrointestinal tract until they reach the inflamed sites of intestine, preventing premature drug release. The negatively charged hybrid nanoparticles selectively target the inflamed sites of intestine, and gradually release drug in response to the microenvironment of inflamed intestine. Overall, the developed hierarchical structured and programmed vehicles load, protect, transport and release drugs locally to inflamed sites of intestine, contributing to superior therapeutic outcomes. Such strategy could also inspire the development of numerous hierarchical structured vehicles by other porous nanoparticles and stimuli-responsive materials for the local delivery of various drugs to treat plenty of inflammatory gastrointestinal diseases, including IBD, gastrointestinal cancers and viral infections.

AB - Orally administrable drug delivery vehicles are developed to manage incurable inflammatory bowel disease (IBD), however, their therapeutic outcomes are compromised by the side effects of systemic drug exposure. Herein, we use hyaluronic acid functionalized porous silicon nanoparticle to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured (nano-in-nano-in-micro) vehicle with programmed properties to fully and sequentially overcome the multiple obstacles for efficiently delivering drugs locally to inflamed sites of intestine. After oral administration, the pH-responsive matrix protects the embedded hybrid nanoparticles containing drug loaded hydrogels against the spatially variable physiological environments of the gastrointestinal tract until they reach the inflamed sites of intestine, preventing premature drug release. The negatively charged hybrid nanoparticles selectively target the inflamed sites of intestine, and gradually release drug in response to the microenvironment of inflamed intestine. Overall, the developed hierarchical structured and programmed vehicles load, protect, transport and release drugs locally to inflamed sites of intestine, contributing to superior therapeutic outcomes. Such strategy could also inspire the development of numerous hierarchical structured vehicles by other porous nanoparticles and stimuli-responsive materials for the local delivery of various drugs to treat plenty of inflammatory gastrointestinal diseases, including IBD, gastrointestinal cancers and viral infections.

KW - 317 Pharmacy

KW - 318 Medical biotechnology

KW - Porous silicon

KW - Hybrid nanoparticle

KW - Stimuli responsive

KW - Targeting

KW - Drug delivery

KW - INFLAMMATORY-BOWEL-DISEASE

KW - MESOPOROUS SILICA NANOPARTICLES

KW - IN-VITRO MODEL

KW - EXPERIMENTAL COLITIS

KW - CHARGED LIPOSOMES

KW - COLONIC-MUCOSA

KW - THERAPY

KW - SIRNA

KW - BIOCOMPATIBILITY

U2 - 10.1016/j.biomaterials.2018.09.024

DO - 10.1016/j.biomaterials.2018.09.024

M3 - Article

VL - 185

SP - 322

EP - 332

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

ER -