Abstract
| Original language | English |
|---|---|
| Journal | Biomaterials |
| Volume | 185 |
| Pages (from-to) | 322-332 |
| Number of pages | 11 |
| ISSN | 0142-9612 |
| DOIs | |
| Publication status | Published - Dec 2018 |
| MoE publication type | A1 Journal article-refereed |
Fields of Science
- 317 Pharmacy
- 318 Medical biotechnology
- Porous silicon
- Hybrid nanoparticle
- Stimuli responsive
- Targeting
- Drug delivery
- INFLAMMATORY-BOWEL-DISEASE
- MESOPOROUS SILICA NANOPARTICLES
- IN-VITRO MODEL
- EXPERIMENTAL COLITIS
- CHARGED LIPOSOMES
- COLONIC-MUCOSA
- THERAPY
- SIRNA
- BIOCOMPATIBILITY
Cite this
}
Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine. / Li, Wei; Li, Yunzhan; Liu, Zehua; Kerdsakundee, Nattha ; Zhang, Ming; Zhang, Feng; Liu, Xueyan; Bauleth-Ramos, Tomás ; Mäkilä, Ermei; Kemell, Marianna; Ding, Yaping; Sarmento, Bruno; Wiwattanapatapee, Ruedeekorn ; Salonen, Jarno; Zhang, Hongbo; Hirvonen, Jouni T.; Liu, Dongfei; Deng, Xianming ; Santos, Hélder A.
In: Biomaterials, Vol. 185, 12.2018, p. 322-332.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine
AU - Li, Wei
AU - Li, Yunzhan
AU - Liu, Zehua
AU - Kerdsakundee, Nattha
AU - Zhang, Ming
AU - Zhang, Feng
AU - Liu, Xueyan
AU - Bauleth-Ramos, Tomás
AU - Mäkilä, Ermei
AU - Kemell, Marianna
AU - Ding, Yaping
AU - Sarmento, Bruno
AU - Wiwattanapatapee, Ruedeekorn
AU - Salonen, Jarno
AU - Zhang, Hongbo
AU - Hirvonen, Jouni T.
AU - Liu, Dongfei
AU - Deng, Xianming
AU - Santos, Hélder A.
PY - 2018/12
Y1 - 2018/12
N2 - Orally administrable drug delivery vehicles are developed to manage incurable inflammatory bowel disease (IBD), however, their therapeutic outcomes are compromised by the side effects of systemic drug exposure. Herein, we use hyaluronic acid functionalized porous silicon nanoparticle to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured (nano-in-nano-in-micro) vehicle with programmed properties to fully and sequentially overcome the multiple obstacles for efficiently delivering drugs locally to inflamed sites of intestine. After oral administration, the pH-responsive matrix protects the embedded hybrid nanoparticles containing drug loaded hydrogels against the spatially variable physiological environments of the gastrointestinal tract until they reach the inflamed sites of intestine, preventing premature drug release. The negatively charged hybrid nanoparticles selectively target the inflamed sites of intestine, and gradually release drug in response to the microenvironment of inflamed intestine. Overall, the developed hierarchical structured and programmed vehicles load, protect, transport and release drugs locally to inflamed sites of intestine, contributing to superior therapeutic outcomes. Such strategy could also inspire the development of numerous hierarchical structured vehicles by other porous nanoparticles and stimuli-responsive materials for the local delivery of various drugs to treat plenty of inflammatory gastrointestinal diseases, including IBD, gastrointestinal cancers and viral infections.
AB - Orally administrable drug delivery vehicles are developed to manage incurable inflammatory bowel disease (IBD), however, their therapeutic outcomes are compromised by the side effects of systemic drug exposure. Herein, we use hyaluronic acid functionalized porous silicon nanoparticle to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured (nano-in-nano-in-micro) vehicle with programmed properties to fully and sequentially overcome the multiple obstacles for efficiently delivering drugs locally to inflamed sites of intestine. After oral administration, the pH-responsive matrix protects the embedded hybrid nanoparticles containing drug loaded hydrogels against the spatially variable physiological environments of the gastrointestinal tract until they reach the inflamed sites of intestine, preventing premature drug release. The negatively charged hybrid nanoparticles selectively target the inflamed sites of intestine, and gradually release drug in response to the microenvironment of inflamed intestine. Overall, the developed hierarchical structured and programmed vehicles load, protect, transport and release drugs locally to inflamed sites of intestine, contributing to superior therapeutic outcomes. Such strategy could also inspire the development of numerous hierarchical structured vehicles by other porous nanoparticles and stimuli-responsive materials for the local delivery of various drugs to treat plenty of inflammatory gastrointestinal diseases, including IBD, gastrointestinal cancers and viral infections.
KW - 317 Pharmacy
KW - 318 Medical biotechnology
KW - Porous silicon
KW - Hybrid nanoparticle
KW - Stimuli responsive
KW - Targeting
KW - Drug delivery
KW - INFLAMMATORY-BOWEL-DISEASE
KW - MESOPOROUS SILICA NANOPARTICLES
KW - IN-VITRO MODEL
KW - EXPERIMENTAL COLITIS
KW - CHARGED LIPOSOMES
KW - COLONIC-MUCOSA
KW - THERAPY
KW - SIRNA
KW - BIOCOMPATIBILITY
U2 - 10.1016/j.biomaterials.2018.09.024
DO - 10.1016/j.biomaterials.2018.09.024
M3 - Article
VL - 185
SP - 322
EP - 332
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
ER -