High frequency of SNAIL-expressing cells confirms and predicts metastatic potential of phaeochromocytoma

Valtteri Häyry, Kaisa Salmenkivi, Johanna Arola, Päivi Heikkilä, Caj Haglund, Hannu Sariola

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    Abstract

    Phaeochromocytomas are uncommon tumours of adrenal or extra-adrenal chromaffin tissue. About 2-26% of these have been reported to metastasize, but, on histological criteria, it is virtually impossible to predict malignant behaviour of the tumour Using immunohistochemistry, we analysed the protein expression of SNAIL, a zinc-finger transcription factor, in a series of 50 phaeochromocytoma specimens from 42 patients. We found that SNAIL-expressing cells are frequent in metastatic primary tumours and their metastases, whereas in tumours without metastases, SNAIL expression is commonly absent We conclude that the expression of SNAIL may be of use in predicting the metastatic potential of phaeochromocytoma. Endocrine-Related Cancer (2009) 16 1211-1218
    Original languageEnglish
    JournalEndocrine - Related Cancer
    Volume16
    Issue number4
    Pages (from-to)1211-1218
    Number of pages8
    ISSN1351-0088
    DOIs
    Publication statusPublished - 2009
    MoE publication typeA1 Journal article-refereed

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