High frequency of SNAIL-expressing cells confirms and predicts metastatic potential of phaeochromocytoma

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Abstract

Phaeochromocytomas are uncommon tumours of adrenal or extra-adrenal chromaffin tissue. About 2-26% of these have been reported to metastasize, but, on histological criteria, it is virtually impossible to predict malignant behaviour of the tumour Using immunohistochemistry, we analysed the protein expression of SNAIL, a zinc-finger transcription factor, in a series of 50 phaeochromocytoma specimens from 42 patients. We found that SNAIL-expressing cells are frequent in metastatic primary tumours and their metastases, whereas in tumours without metastases, SNAIL expression is commonly absent We conclude that the expression of SNAIL may be of use in predicting the metastatic potential of phaeochromocytoma. Endocrine-Related Cancer (2009) 16 1211-1218
Original languageEnglish
JournalEndocrine - Related Cancer
Volume16
Issue number4
Pages (from-to)1211-1218
Number of pages8
ISSN1351-0088
DOIs
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed

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