HIV-1 Nef-Induced Secretion of the Proinflammatory Protease TACE into Extracellular Vesicles Is Mediated by Raf-1 and Can Be Suppressed by Clinical Protein Kinase Inhibitors

Zhe Zhao, Riku Fagerlund, Andreas S. Baur, Kalle Saksela

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
Article numberARTN e00180-21
JournalJournal of Virology
Volume95
Issue number9
Number of pages11
ISSN0022-538X
DOIs
Publication statusPublished - May 2021
MoE publication typeA1 Journal article-refereed

Fields of Science

  • ADAM17
  • HIV-1
  • Hck
  • Nef
  • Raf
  • TACE
  • extracellular vesicles
  • kinase inhibitor
  • SRC FAMILY KINASES
  • SIMIAN-IMMUNODEFICIENCY-VIRUS
  • BIOLOGICAL-ACTIVITY
  • MEK INHIBITORS
  • SH3 DOMAINS
  • TYPE-1 NEF
  • ACTIVATION
  • BINDING
  • HCK
  • SURFACE
  • 3111 Biomedicine
  • 11832 Microbiology and virology

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