HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis

Donna Kennedy; Katarzyna Mnich; Deepu Oommen; Reka Chakravarthy; Leonardo Almeida-Souza; Michiel Krols; Svetlana Saveljeva; Karen Doyle; Sanjeev Gupta; Vincent Timmerman; Sophie Janssens; Adrienne M. Gorman; Afshin Samali

doi:10.1038/cddis.2017.408

HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis

Donna Kennedy, Katarzyna Mnich, Deepu Oommen, Reka Chakravarthy, Leonardo Almeida-Souza, Michiel Krols, Svetlana Saveljeva, Karen Doyle, Sanjeev Gupta, Vincent Timmerman, Sophie Janssens, Adrienne M. Gorman, Afshin Samali

Helsinki Institute of Life Science HiLIFE

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	3026
Journal	Cell Death and Disease
Volume	8
Number of pages	13
ISSN	2041-4889
DOIs	https://doi.org/10.1038/cddis.2017.408
Publication status	Published - Aug 2017
MoE publication type	A1 Journal article-refereed

Fields of Science

HEAT-SHOCK PROTEINS
CYTOCHROME-C RELEASE
BH3-ONLY PROTEIN
PC12 CELLS
MEMBRANE PERMEABILIZATION
PROTEASOMAL DEGRADATION
MITOCHONDRIAL-MEMBRANE
APAF-1 APOPTOSOME
BCL-2 PROTEINS
HSP27

Access to Document

10.1038/cddis.2017.408

Cite this

Kennedy, D., Mnich, K., Oommen, D., Chakravarthy, R., Almeida-Souza, L., Krols, M., Saveljeva, S., Doyle, K., Gupta, S., Timmerman, V., Janssens, S., Gorman, A. M., & Samali, A. (2017). HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis. Cell Death and Disease, 8, [3026]. https://doi.org/10.1038/cddis.2017.408

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title = "HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis",

keywords = "HEAT-SHOCK PROTEINS, CYTOCHROME-C RELEASE, BH3-ONLY PROTEIN, PC12 CELLS, MEMBRANE PERMEABILIZATION, PROTEASOMAL DEGRADATION, MITOCHONDRIAL-MEMBRANE, APAF-1 APOPTOSOME, BCL-2 PROTEINS, HSP27",

author = "Donna Kennedy and Katarzyna Mnich and Deepu Oommen and Reka Chakravarthy and Leonardo Almeida-Souza and Michiel Krols and Svetlana Saveljeva and Karen Doyle and Sanjeev Gupta and Vincent Timmerman and Sophie Janssens and Gorman, {Adrienne M.} and Afshin Samali",

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month = aug,

doi = "10.1038/cddis.2017.408",

language = "English",

volume = "8",

journal = "Cell Death and Disease",

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Kennedy, D, Mnich, K, Oommen, D, Chakravarthy, R, Almeida-Souza, L, Krols, M, Saveljeva, S, Doyle, K, Gupta, S, Timmerman, V, Janssens, S, Gorman, AM & Samali, A 2017, 'HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis', Cell Death and Disease, vol. 8, 3026. https://doi.org/10.1038/cddis.2017.408

TY - JOUR

T1 - HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis

AU - Kennedy, Donna

AU - Mnich, Katarzyna

AU - Oommen, Deepu

AU - Chakravarthy, Reka

AU - Almeida-Souza, Leonardo

AU - Krols, Michiel

AU - Saveljeva, Svetlana

AU - Doyle, Karen

AU - Gupta, Sanjeev

AU - Timmerman, Vincent

AU - Janssens, Sophie

AU - Gorman, Adrienne M.

AU - Samali, Afshin

PY - 2017/8

Y1 - 2017/8

KW - HEAT-SHOCK PROTEINS

KW - CYTOCHROME-C RELEASE

KW - BH3-ONLY PROTEIN

KW - PC12 CELLS

KW - MEMBRANE PERMEABILIZATION

KW - PROTEASOMAL DEGRADATION

KW - MITOCHONDRIAL-MEMBRANE

KW - APAF-1 APOPTOSOME

KW - BCL-2 PROTEINS

KW - HSP27

U2 - 10.1038/cddis.2017.408

DO - 10.1038/cddis.2017.408

M3 - Article

VL - 8

JO - Cell Death and Disease

JF - Cell Death and Disease

SN - 2041-4889

M1 - 3026

ER -