Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

Eva Mittler; Anna Z. Wec; Janne Tynell; Pablo Guardado-Calvo; Julia Wigren-Bystrom; Laura C. Polanco; Cecilia M. O'Brien; Megan M. Slough; Dafna M. Abelson; Alexandra Serris; Mrunal Sakharkar; Gerard Pehau-Arnaudet; Russell R. Bakken; James C. Geoghegan; Rohit K. Jangra; Markus Keller; Larry Zeitlin; Olli Vapalahti; Rainer G. Ulrich; Zachary A. Bornholdt; Clas Ahlm; Felix A. Rey; John M. Dye; Steven B. Bradfute; Tomas Strandin; Andrew S. Herbert; Mattias N. E. Forsell; Laura M. Walker; Kartik Chandran

doi:10.1126/scitranslmed.abl5399

Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

Eva Mittler, Anna Z. Wec, Janne Tynell, Pablo Guardado-Calvo, Julia Wigren-Bystrom, Laura C. Polanco, Cecilia M. O'Brien, Megan M. Slough, Dafna M. Abelson, Alexandra Serris, Mrunal Sakharkar, Gerard Pehau-Arnaudet, Russell R. Bakken, James C. Geoghegan, Rohit K. Jangra, Markus Keller, Larry Zeitlin, Olli Vapalahti, Rainer G. Ulrich, Zachary A. BornholdtClas Ahlm, Felix A. Rey, John M. Dye, Steven B. Bradfute, Tomas Strandin, Andrew S. Herbert, Mattias N. E. Forsell, Laura M. Walker, Kartik Chandran

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	5399
Journal	Science translational medicine
Volume	14
Issue number	636
Number of pages	16
ISSN	1946-6234
DOIs	https://doi.org/10.1126/scitranslmed.abl5399
Publication status	Published - 16 Mar 2022
MoE publication type	A1 Journal article-refereed

Fields of Science

HUMORAL IMMUNE-RESPONSES
NEUTRALIZING ANTIBODIES
ANDES HANTAVIRUS
MONOCLONAL-ANTIBODIES
INFECTIONS
EPIDEMIOLOGY
SURVIVOR
BURDEN
FUSION
ENTRY
3111 Biomedicine
11832 Microbiology and virology

Access to Document

10.1126/scitranslmed.abl5399

Cite this

Mittler, E., Wec, A. Z., Tynell, J., Guardado-Calvo, P., Wigren-Bystrom, J., Polanco, L. C., O'Brien, C. M., Slough, M. M., Abelson, D. M., Serris, A., Sakharkar, M., Pehau-Arnaudet, G., Bakken, R. R., Geoghegan, J. C., Jangra, R. K., Keller, M., Zeitlin, L., Vapalahti, O., Ulrich, R. G., ... Chandran, K. (2022). Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses. Science translational medicine, 14(636), [5399]. https://doi.org/10.1126/scitranslmed.abl5399

@article{54ddcdb38cf045528aa5673d4ea4898e,

title = "Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses",

keywords = "HUMORAL IMMUNE-RESPONSES, NEUTRALIZING ANTIBODIES, ANDES HANTAVIRUS, MONOCLONAL-ANTIBODIES, INFECTIONS, EPIDEMIOLOGY, SURVIVOR, BURDEN, FUSION, ENTRY, 3111 Biomedicine, 11832 Microbiology and virology",

author = "Eva Mittler and Wec, {Anna Z.} and Janne Tynell and Pablo Guardado-Calvo and Julia Wigren-Bystrom and Polanco, {Laura C.} and O'Brien, {Cecilia M.} and Slough, {Megan M.} and Abelson, {Dafna M.} and Alexandra Serris and Mrunal Sakharkar and Gerard Pehau-Arnaudet and Bakken, {Russell R.} and Geoghegan, {James C.} and Jangra, {Rohit K.} and Markus Keller and Larry Zeitlin and Olli Vapalahti and Ulrich, {Rainer G.} and Bornholdt, {Zachary A.} and Clas Ahlm and Rey, {Felix A.} and Dye, {John M.} and Bradfute, {Steven B.} and Tomas Strandin and Herbert, {Andrew S.} and Forsell, {Mattias N. E.} and Walker, {Laura M.} and Kartik Chandran",

year = "2022",

month = mar,

day = "16",

doi = "10.1126/scitranslmed.abl5399",

language = "English",

volume = "14",

journal = "Science translational medicine",

issn = "1946-6234",

publisher = "American Association for the Advancement of Science (AAAS)",

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Mittler, E, Wec, AZ, Tynell, J, Guardado-Calvo, P, Wigren-Bystrom, J, Polanco, LC, O'Brien, CM, Slough, MM, Abelson, DM, Serris, A, Sakharkar, M, Pehau-Arnaudet, G, Bakken, RR, Geoghegan, JC, Jangra, RK, Keller, M, Zeitlin, L, Vapalahti, O, Ulrich, RG, Bornholdt, ZA, Ahlm, C, Rey, FA, Dye, JM, Bradfute, SB, Strandin, T, Herbert, AS, Forsell, MNE, Walker, LM & Chandran, K 2022, 'Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses', Science translational medicine, vol. 14, no. 636, 5399. https://doi.org/10.1126/scitranslmed.abl5399

TY - JOUR

T1 - Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

AU - Mittler, Eva

AU - Wec, Anna Z.

AU - Tynell, Janne

AU - Guardado-Calvo, Pablo

AU - Wigren-Bystrom, Julia

AU - Polanco, Laura C.

AU - O'Brien, Cecilia M.

AU - Slough, Megan M.

AU - Abelson, Dafna M.

AU - Serris, Alexandra

AU - Sakharkar, Mrunal

AU - Pehau-Arnaudet, Gerard

AU - Bakken, Russell R.

AU - Geoghegan, James C.

AU - Jangra, Rohit K.

AU - Keller, Markus

AU - Zeitlin, Larry

AU - Vapalahti, Olli

AU - Ulrich, Rainer G.

AU - Bornholdt, Zachary A.

AU - Ahlm, Clas

AU - Rey, Felix A.

AU - Dye, John M.

AU - Bradfute, Steven B.

AU - Strandin, Tomas

AU - Herbert, Andrew S.

AU - Forsell, Mattias N. E.

AU - Walker, Laura M.

AU - Chandran, Kartik

PY - 2022/3/16

Y1 - 2022/3/16

KW - HUMORAL IMMUNE-RESPONSES

KW - NEUTRALIZING ANTIBODIES

KW - ANDES HANTAVIRUS

KW - MONOCLONAL-ANTIBODIES

KW - INFECTIONS

KW - EPIDEMIOLOGY

KW - SURVIVOR

KW - BURDEN

KW - FUSION

KW - ENTRY

KW - 3111 Biomedicine

KW - 11832 Microbiology and virology

U2 - 10.1126/scitranslmed.abl5399

DO - 10.1126/scitranslmed.abl5399

M3 - Article

VL - 14

JO - Science translational medicine

JF - Science translational medicine

SN - 1946-6234

IS - 636

M1 - 5399

ER -