Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes

Ying-Chieh Wu; Sarka Lehtonen; Kalevi Trontti; Riitta Kauppinen; Pinja Kettunen; Ville Leinonen; Markku Laakso; Johanna Kuusisto; Mikko Hiltunen; Iiris Hovatta; Kristine Freude; Hiramani Dhungana; Jari Koistinaho; Taisia Rolova

doi:10.1186/s12987-024-00576-y

Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes

Ying-Chieh Wu, Sarka Lehtonen, Kalevi Trontti, Riitta Kauppinen, Pinja Kettunen, Ville Leinonen, Markku Laakso, Johanna Kuusisto, Mikko Hiltunen, Iiris Hovatta, Kristine Freude, Hiramani Dhungana, Jari Koistinaho, Taisia Rolova

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	78
Journal	Fluids and barriers of the CNS
Volume	21
Issue number	1
Number of pages	20
ISSN	2045-8118
DOIs	https://doi.org/10.1186/s12987-024-00576-y
Publication status	Published - 27 Sept 2024
MoE publication type	A1 Journal article-refereed

Fields of Science

Alzheimer's disease
Cerebral amyloid angiopathy
Pericytes
Vascular dysfunction
IPSCs
3112 Neurosciences

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10.1186/s12987-024-00576-yLicence: CC BY-NC-ND

s12987-024-00576-yFinal published version, 8.16 MBLicence: CC BY-NC-ND

Cite this

Wu, Y.-C., Lehtonen, S., Trontti, K., Kauppinen, R., Kettunen, P., Leinonen, V., Laakso, M., Kuusisto, J., Hiltunen, M., Hovatta, I., Freude, K., Dhungana, H., Koistinaho, J., & Rolova, T. (2024). Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes. Fluids and barriers of the CNS, 21(1), Article 78. https://doi.org/10.1186/s12987-024-00576-y

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keywords = "Alzheimer's disease, Cerebral amyloid angiopathy, Pericytes, Vascular dysfunction, IPSCs, 3112 Neurosciences",

author = "Ying-Chieh Wu and Sarka Lehtonen and Kalevi Trontti and Riitta Kauppinen and Pinja Kettunen and Ville Leinonen and Markku Laakso and Johanna Kuusisto and Mikko Hiltunen and Iiris Hovatta and Kristine Freude and Hiramani Dhungana and Jari Koistinaho and Taisia Rolova",

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Wu, Y-C , Lehtonen, S , Trontti, K, Kauppinen, R, Kettunen, P, Leinonen, V, Laakso, M, Kuusisto, J, Hiltunen, M, Hovatta, I, Freude, K, Dhungana, H , Koistinaho, J & Rolova, T 2024, 'Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes', Fluids and barriers of the CNS, vol. 21, no. 1, 78. https://doi.org/10.1186/s12987-024-00576-y

TY - JOUR

T1 - Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes

AU - Wu, Ying-Chieh

AU - Lehtonen, Sarka

AU - Trontti, Kalevi

AU - Kauppinen, Riitta

AU - Kettunen, Pinja

AU - Leinonen, Ville

AU - Laakso, Markku

AU - Kuusisto, Johanna

AU - Hiltunen, Mikko

AU - Hovatta, Iiris

AU - Freude, Kristine

AU - Dhungana, Hiramani

AU - Koistinaho, Jari

AU - Rolova, Taisia

PY - 2024/9/27

Y1 - 2024/9/27

KW - Alzheimer's disease

KW - Cerebral amyloid angiopathy

KW - Pericytes

KW - Vascular dysfunction

KW - IPSCs

KW - 3112 Neurosciences

U2 - 10.1186/s12987-024-00576-y

DO - 10.1186/s12987-024-00576-y

M3 - Article

C2 - 39334385

SN - 2045-8118

VL - 21

JO - Fluids and barriers of the CNS

JF - Fluids and barriers of the CNS

IS - 1

M1 - 78

ER -