Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

Henna Jäntti; Minna Oksanen; Pinja Kettunen; Stella Manta; Lionel Mouledous; Hennariikka Koivisto; Johanna Ruuth; Kalevi Trontti; Hiramani Dhungana; Meike Keuters; Isabelle Weert; Marja Koskuvi; Iiris Hovatta; Anni Maija Linden; Claire Rampon; Tarja Malm; Heikki Tanila; Jari Koistinaho; Taisia Rolova

doi:10.3390/cells11244116

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

Henna Jäntti, Minna Oksanen, Pinja Kettunen, Stella Manta, Lionel Mouledous, Hennariikka Koivisto, Johanna Ruuth, Kalevi Trontti, Hiramani Dhungana, Meike Keuters, Isabelle Weert, Marja Koskuvi, Iiris Hovatta, Anni Maija Linden, Claire Rampon, Tarja Malm, Heikki Tanila, Jari Koistinaho, Taisia Rolova

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	4116
Journal	Cells
Volume	11
Issue number	24
Number of pages	28
ISSN	2073-4409
DOIs	https://doi.org/10.3390/cells11244116
Publication status	Published - Dec 2022
MoE publication type	A1 Journal article-refereed

Bibliographical note

Funding Information:
We thank Laila Kaskela, Eila Korhonen, and Erja Huttu for their outstanding technical assistance. RNA sequencing was carried out using the services of the Biomedicum Functional Genomics Unit at the Helsinki Institute of Life Science and Biocenter Finland, University of Helsinki. Open access funding was provided by the University of Helsinki.

Funding Information:
The project was funded through the following funding organizations under the aegis of JPND: Finland, Academy of Finland (No 301253 J.K., 301234 T.M.); France, Agence Nationale de la Recherche (C.R.). This project has also received funding from the European Union’s Horizon 2020 research and innovation program (grant agreement No 643417), from Sigrid Juselius Foundation, from Business Finland, and from Biocenter Finland through Biocenter Kuopio (H.T.). Grant numbers are not applicable for the latter foundations. Open access funding was provided by the University of Helsinki.

Publisher Copyright:
© 2022 by the authors.

Fields of Science

Alzheimer’s disease
astrocytes
experimental transplantation
iPSC
oligodendrocyte precursor cells
presenilin
3124 Neurology and psychiatry

Access to Document

10.3390/cells11244116

http://hdl.handle.net/10138/352187Licence: CC BY

Cite this

Jäntti, H., Oksanen, M., Kettunen, P., Manta, S., Mouledous, L., Koivisto, H., Ruuth, J., Trontti, K., Dhungana, H., Keuters, M., Weert, I., Koskuvi, M., Hovatta, I., Linden, A. M., Rampon, C., Malm, T., Tanila, H., Koistinaho, J., & Rolova, T. (2022). Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice. Cells, 11(24), Article 4116. https://doi.org/10.3390/cells11244116

@article{d24790fa92454b76a7963ba566dd8d77,

title = "Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice",

keywords = "Alzheimer{\textquoteright}s disease, astrocytes, experimental transplantation, iPSC, oligodendrocyte precursor cells, presenilin, 3124 Neurology and psychiatry",

author = "Henna J{\"a}ntti and Minna Oksanen and Pinja Kettunen and Stella Manta and Lionel Mouledous and Hennariikka Koivisto and Johanna Ruuth and Kalevi Trontti and Hiramani Dhungana and Meike Keuters and Isabelle Weert and Marja Koskuvi and Iiris Hovatta and Linden, {Anni Maija} and Claire Rampon and Tarja Malm and Heikki Tanila and Jari Koistinaho and Taisia Rolova",

note = "Funding Information: We thank Laila Kaskela, Eila Korhonen, and Erja Huttu for their outstanding technical assistance. RNA sequencing was carried out using the services of the Biomedicum Functional Genomics Unit at the Helsinki Institute of Life Science and Biocenter Finland, University of Helsinki. Open access funding was provided by the University of Helsinki. Funding Information: The project was funded through the following funding organizations under the aegis of JPND: Finland, Academy of Finland (No 301253 J.K., 301234 T.M.); France, Agence Nationale de la Recherche (C.R.). This project has also received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation program (grant agreement No 643417), from Sigrid Juselius Foundation, from Business Finland, and from Biocenter Finland through Biocenter Kuopio (H.T.). Grant numbers are not applicable for the latter foundations. Open access funding was provided by the University of Helsinki. Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = dec,

doi = "10.3390/cells11244116",

language = "English",

volume = "11",

journal = "Cells",

issn = "2073-4409",

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Jäntti, H, Oksanen, M, Kettunen, P, Manta, S, Mouledous, L, Koivisto, H, Ruuth, J, Trontti, K , Dhungana, H , Keuters, M, Weert, I, Koskuvi, M , Hovatta, I , Linden, AM, Rampon, C, Malm, T, Tanila, H, Koistinaho, J & Rolova, T 2022, 'Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice', Cells, vol. 11, no. 24, 4116. https://doi.org/10.3390/cells11244116

TY - JOUR

T1 - Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

AU - Jäntti, Henna

AU - Oksanen, Minna

AU - Kettunen, Pinja

AU - Manta, Stella

AU - Mouledous, Lionel

AU - Koivisto, Hennariikka

AU - Ruuth, Johanna

AU - Trontti, Kalevi

AU - Dhungana, Hiramani

AU - Keuters, Meike

AU - Weert, Isabelle

AU - Koskuvi, Marja

AU - Hovatta, Iiris

AU - Linden, Anni Maija

AU - Rampon, Claire

AU - Malm, Tarja

AU - Tanila, Heikki

AU - Koistinaho, Jari

AU - Rolova, Taisia

N1 - Funding Information: We thank Laila Kaskela, Eila Korhonen, and Erja Huttu for their outstanding technical assistance. RNA sequencing was carried out using the services of the Biomedicum Functional Genomics Unit at the Helsinki Institute of Life Science and Biocenter Finland, University of Helsinki. Open access funding was provided by the University of Helsinki. Funding Information: The project was funded through the following funding organizations under the aegis of JPND: Finland, Academy of Finland (No 301253 J.K., 301234 T.M.); France, Agence Nationale de la Recherche (C.R.). This project has also received funding from the European Union’s Horizon 2020 research and innovation program (grant agreement No 643417), from Sigrid Juselius Foundation, from Business Finland, and from Biocenter Finland through Biocenter Kuopio (H.T.). Grant numbers are not applicable for the latter foundations. Open access funding was provided by the University of Helsinki. Publisher Copyright: © 2022 by the authors.

PY - 2022/12

Y1 - 2022/12

KW - Alzheimer’s disease

KW - astrocytes

KW - experimental transplantation

KW - iPSC

KW - oligodendrocyte precursor cells

KW - presenilin

KW - 3124 Neurology and psychiatry

U2 - 10.3390/cells11244116

DO - 10.3390/cells11244116

M3 - Article

C2 - 36552881

AN - SCOPUS:85144482288

SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

IS - 24

M1 - 4116

ER -