Hyaluronic Acid Graft Copolymers with Cleavable Arms as Potential Intravitreal Drug Delivery Vehicles

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Treatment of retinal diseases currently demands frequent intravitreal injections due to rapid clearance of the therapeutics. The use of high molecular weight polymers can extend the residence time in the vitreous and prolong the injection intervals. This study reports a water soluble graft copolymer as a potential vehicle for sustained intravitreal drug delivery. The copolymer features a high molecular weight hyaluronic acid (HA) backbone and poly(glyceryl glycerol) (PGG) side chains attached via hydrolysable ester linkers. PGG, a polyether with 1,2-diol groups in every repeating unit available for conjugation, serves as a detachable carrier. The influence of synthesis conditions and incubation in physiological media on the molecular weight of HA is studied. The cleavage of the PGG grafts from the HA backbone is quantified and polymer-from-polymer release kinetics are determined. The biocompatibility of the materials is tested in different cell cultures.
Original languageEnglish
Article number1700200
JournalMacromolecular Bioscience
Volume18
Issue number1
Number of pages13
ISSN1616-5187
DOIs
Publication statusPublished - 1 Jan 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 116 Chemical sciences
  • drug delivery vehicle
  • hyaluronic acid
  • poly(glyceryl glycerol)
  • polymer-from-polymer release
  • vitreous

Cite this

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title = "Hyaluronic Acid Graft Copolymers with Cleavable Arms as Potential Intravitreal Drug Delivery Vehicles",
abstract = "Treatment of retinal diseases currently demands frequent intravitreal injections due to rapid clearance of the therapeutics. The use of high molecular weight polymers can extend the residence time in the vitreous and prolong the injection intervals. This study reports a water soluble graft copolymer as a potential vehicle for sustained intravitreal drug delivery. The copolymer features a high molecular weight hyaluronic acid (HA) backbone and poly(glyceryl glycerol) (PGG) side chains attached via hydrolysable ester linkers. PGG, a polyether with 1,2-diol groups in every repeating unit available for conjugation, serves as a detachable carrier. The influence of synthesis conditions and incubation in physiological media on the molecular weight of HA is studied. The cleavage of the PGG grafts from the HA backbone is quantified and polymer-from-polymer release kinetics are determined. The biocompatibility of the materials is tested in different cell cultures.",
keywords = "116 Chemical sciences, drug delivery vehicle, hyaluronic acid, poly(glyceryl glycerol), polymer-from-polymer release, vitreous",
author = "Tina Borke and Mathie Najberg and Polina Ilina and Madhushree Bhattacharya and Arto Urtti and Heikki Tenhu and Sami Hietala",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/mabi.201700200",
language = "English",
volume = "18",
journal = "Macromolecular Bioscience",
issn = "1616-5187",
publisher = "Wiley-VCH",
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Hyaluronic Acid Graft Copolymers with Cleavable Arms as Potential Intravitreal Drug Delivery Vehicles. / Borke, Tina; Najberg, Mathie; Ilina, Polina; Bhattacharya, Madhushree; Urtti, Arto; Tenhu, Heikki; Hietala, Sami.

In: Macromolecular Bioscience, Vol. 18, No. 1, 1700200, 01.01.2018.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Hyaluronic Acid Graft Copolymers with Cleavable Arms as Potential Intravitreal Drug Delivery Vehicles

AU - Borke, Tina

AU - Najberg, Mathie

AU - Ilina, Polina

AU - Bhattacharya, Madhushree

AU - Urtti, Arto

AU - Tenhu, Heikki

AU - Hietala, Sami

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AB - Treatment of retinal diseases currently demands frequent intravitreal injections due to rapid clearance of the therapeutics. The use of high molecular weight polymers can extend the residence time in the vitreous and prolong the injection intervals. This study reports a water soluble graft copolymer as a potential vehicle for sustained intravitreal drug delivery. The copolymer features a high molecular weight hyaluronic acid (HA) backbone and poly(glyceryl glycerol) (PGG) side chains attached via hydrolysable ester linkers. PGG, a polyether with 1,2-diol groups in every repeating unit available for conjugation, serves as a detachable carrier. The influence of synthesis conditions and incubation in physiological media on the molecular weight of HA is studied. The cleavage of the PGG grafts from the HA backbone is quantified and polymer-from-polymer release kinetics are determined. The biocompatibility of the materials is tested in different cell cultures.

KW - 116 Chemical sciences

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KW - poly(glyceryl glycerol)

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