Hydroxysteroid 17-beta dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease

Panu K. Luukkonen; Taru Tukiainen; Anne Juuti; Henna Sammalkorpi; P. A. Nidhina Haridas; Onni Niemelä; Johanna Arola; Marju Orho-Melander; Antti Hakkarainen; Petri T. Kovanen; Om Dwivedi; Leif Groop; Leanne Hodson; Amalia Gastaldelli; Tuulia Hyötyläinen; Matej Oresic; Hannele Yki-Järvinen

doi:10.1172/jci.insight.132158

Hydroxysteroid 17-beta dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease

Panu K. Luukkonen, Taru Tukiainen, Anne Juuti, Henna Sammalkorpi, P. A. Nidhina Haridas, Onni Niemelä, Johanna Arola, Marju Orho-Melander, Antti Hakkarainen, Petri T. Kovanen, Om Dwivedi, Leif Groop, Leanne Hodson, Amalia Gastaldelli, Tuulia Hyötyläinen, Matej Oresic, Hannele Yki-Järvinen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	132158
Journal	JCI INSIGHT
Volume	5
Issue number	5
Number of pages	12
ISSN	2379-3708
DOIs	https://doi.org/10.1172/jci.insight.132158
Publication status	Published - 12 Mar 2020
MoE publication type	A1 Journal article-refereed

Fields of Science

DE-NOVO LIPOGENESIS
INSULIN-RESISTANCE
PHOSPHATIDYLCHOLINE
CHOLINE
GLUCOSE
STEATOHEPATITIS
INDIVIDUALS
HOMEOSTASIS
NUTRIENT
PACKAGE
3121 General medicine, internal medicine and other clinical medicine

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10.1172/jci.insight.132158Licence: Unspecified

132158.1-20200310141931-covered-253bed37ca4c1ab43d105aefdf7b5536Final published version, 1.69 MBLicence: Unspecified

Insights into the underpinnings of sex differences in health and disease through human genomics
Tukiainen, T. (Project manager), Benoit-Pilven, C. (Participant), Leinonen, J. (Participant), Fu, Y. (Participant), Lehtonen, L. (Participant), Preussner, A. K. (Participant), Vartiainen, E. A. H. (Participant), Asteljoki, J. V. (Participant) & Mielikäinen, L. J. (Participant)
Helsingin yliopisto
01/01/2019 → 31/12/2022
Project: University of Helsinki Three-Year Research Project

Cite this

Luukkonen, P. K., Tukiainen, T., Juuti, A., Sammalkorpi, H., Haridas, P. A. N., Niemelä, O., Arola, J., Orho-Melander, M., Hakkarainen, A., Kovanen, P. T., Dwivedi, O., Groop, L., Hodson, L., Gastaldelli, A., Hyötyläinen, T., Oresic, M., & Yki-Järvinen, H. (2020). Hydroxysteroid 17-beta dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. JCI INSIGHT, 5(5), Article 132158. https://doi.org/10.1172/jci.insight.132158

@article{159a42693a20434eb8239749ae63c848,

title = "Hydroxysteroid 17-beta dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease",

keywords = "DE-NOVO LIPOGENESIS, INSULIN-RESISTANCE, PHOSPHATIDYLCHOLINE, CHOLINE, GLUCOSE, STEATOHEPATITIS, INDIVIDUALS, HOMEOSTASIS, NUTRIENT, PACKAGE, 3121 General medicine, internal medicine and other clinical medicine",

author = "Luukkonen, \{Panu K.\} and Taru Tukiainen and Anne Juuti and Henna Sammalkorpi and Haridas, \{P. A. Nidhina\} and Onni Niemel{\"a} and Johanna Arola and Marju Orho-Melander and Antti Hakkarainen and Kovanen, \{Petri T.\} and Om Dwivedi and Leif Groop and Leanne Hodson and Amalia Gastaldelli and Tuulia Hy{\"o}tyl{\"a}inen and Matej Oresic and Hannele Yki-J{\"a}rvinen",

year = "2020",

month = mar,

day = "12",

doi = "10.1172/jci.insight.132158",

language = "English",

volume = "5",

journal = "JCI INSIGHT",

issn = "2379-3708",

publisher = "AMERICAN SOCIETY FOR CLINICAL INVESTIGATION",

number = "5",

}

Luukkonen, PK , Tukiainen, T , Juuti, A, Sammalkorpi, H, Haridas, PAN, Niemelä, O, Arola, J, Orho-Melander, M, Hakkarainen, A , Kovanen, PT , Dwivedi, O , Groop, L, Hodson, L, Gastaldelli, A, Hyötyläinen, T, Oresic, M & Yki-Järvinen, H 2020, 'Hydroxysteroid 17-beta dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease', JCI INSIGHT, vol. 5, no. 5, 132158. https://doi.org/10.1172/jci.insight.132158

TY - JOUR

T1 - Hydroxysteroid 17-beta dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease

AU - Luukkonen, Panu K.

AU - Tukiainen, Taru

AU - Juuti, Anne

AU - Sammalkorpi, Henna

AU - Haridas, P. A. Nidhina

AU - Niemelä, Onni

AU - Arola, Johanna

AU - Orho-Melander, Marju

AU - Hakkarainen, Antti

AU - Kovanen, Petri T.

AU - Dwivedi, Om

AU - Groop, Leif

AU - Hodson, Leanne

AU - Gastaldelli, Amalia

AU - Hyötyläinen, Tuulia

AU - Oresic, Matej

AU - Yki-Järvinen, Hannele

PY - 2020/3/12

Y1 - 2020/3/12

KW - DE-NOVO LIPOGENESIS

KW - INSULIN-RESISTANCE

KW - PHOSPHATIDYLCHOLINE

KW - CHOLINE

KW - GLUCOSE

KW - STEATOHEPATITIS

KW - INDIVIDUALS

KW - HOMEOSTASIS

KW - NUTRIENT

KW - PACKAGE

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1172/jci.insight.132158

DO - 10.1172/jci.insight.132158

M3 - Article

SN - 2379-3708

VL - 5

JO - JCI INSIGHT

JF - JCI INSIGHT

IS - 5

M1 - 132158

ER -

Hydroxysteroid 17-beta dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease

Fields of Science

Access to Document

Projects

Insights into the underpinnings of sex differences in health and disease through human genomics

Cite this