Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma

Petra Miikkulainen, Heidi Högel, Fatemeh Seyednasrollah, Krista Rantanen, Laura L. Elo, Panu M. Jaakkola

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Biological Chemistry
Volume294
Issue number10
Pages (from-to)3760-3771
Number of pages12
ISSN0021-9258
DOIs
Publication statusPublished - 8 Mar 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • cancer
  • cancer biology
  • hypoxia
  • hypoxia-inducible factor (HIF)
  • mRNA decay
  • ccRCC
  • Egl-9 family hypoxia-inducible factor 3 (EGLN3)
  • post-transcriptional regulation
  • prolyl hydroxylase PHD3
  • renal cell carcinoma
  • PROLYL HYDROXYLASES
  • GENE-EXPRESSION
  • TRANSCRIPTION
  • HIF-1-ALPHA
  • PROTEIN
  • TRANSLATION
  • PROTEASOME
  • STABILITY
  • CANCER
  • HIF-1
  • 1182 Biochemistry, cell and molecular biology
  • 3122 Cancers

Cite this

Miikkulainen, Petra ; Högel, Heidi ; Seyednasrollah, Fatemeh ; Rantanen, Krista ; Elo, Laura L. ; Jaakkola, Panu M. / Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma. In: Journal of Biological Chemistry. 2019 ; Vol. 294, No. 10. pp. 3760-3771.
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title = "Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma",
keywords = "cancer, cancer biology, hypoxia, hypoxia-inducible factor (HIF), mRNA decay, ccRCC, Egl-9 family hypoxia-inducible factor 3 (EGLN3), post-transcriptional regulation, prolyl hydroxylase PHD3, renal cell carcinoma, PROLYL HYDROXYLASES, GENE-EXPRESSION, TRANSCRIPTION, HIF-1-ALPHA, PROTEIN, TRANSLATION, PROTEASOME, STABILITY, CANCER, HIF-1, 1182 Biochemistry, cell and molecular biology, 3122 Cancers",
author = "Petra Miikkulainen and Heidi H{\"o}gel and Fatemeh Seyednasrollah and Krista Rantanen and Elo, {Laura L.} and Jaakkola, {Panu M.}",
year = "2019",
month = "3",
day = "8",
doi = "10.1074/jbc.RA118.004902",
language = "English",
volume = "294",
pages = "3760--3771",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology",
number = "10",

}

Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma. / Miikkulainen, Petra; Högel, Heidi; Seyednasrollah, Fatemeh; Rantanen, Krista; Elo, Laura L.; Jaakkola, Panu M.

In: Journal of Biological Chemistry, Vol. 294, No. 10, 08.03.2019, p. 3760-3771.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma

AU - Miikkulainen, Petra

AU - Högel, Heidi

AU - Seyednasrollah, Fatemeh

AU - Rantanen, Krista

AU - Elo, Laura L.

AU - Jaakkola, Panu M.

PY - 2019/3/8

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KW - cancer

KW - cancer biology

KW - hypoxia

KW - hypoxia-inducible factor (HIF)

KW - mRNA decay

KW - ccRCC

KW - Egl-9 family hypoxia-inducible factor 3 (EGLN3)

KW - post-transcriptional regulation

KW - prolyl hydroxylase PHD3

KW - renal cell carcinoma

KW - PROLYL HYDROXYLASES

KW - GENE-EXPRESSION

KW - TRANSCRIPTION

KW - HIF-1-ALPHA

KW - PROTEIN

KW - TRANSLATION

KW - PROTEASOME

KW - STABILITY

KW - CANCER

KW - HIF-1

KW - 1182 Biochemistry, cell and molecular biology

KW - 3122 Cancers

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DO - 10.1074/jbc.RA118.004902

M3 - Article

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EP - 3771

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