ICAM-5 - A novel two-facetted adhesion molecule in the mammalian brain

Carl G Gahmberg, Li Tian, Lin Ning, Henrietta Nyman-Huttunen

    Research output: Contribution to journalArticleScientificpeer-review


    Cell adhesion is of utmost importance for normal development and cellular functions. ICAM-5 (intercellular adhesion molecule-5, telencephalin) is a member of the ICAM-family of adhesion proteins. These proteins bind to leukocyte beta(2)-integrins (CD11/CD18), but ICAM-5 is exceptional in several ways. It is solely expressed in the mammalian forebrain, appears at the time of birth, and is located in the soma and dendrites of neurons. It is structurally more complex than the others, and also shows homophilic adhesion. Recent studies show that it is important for the regulation of immunological activity in the brain and for the development of neuronal synapses and signal transmission. (c) 2008 Elsevier B.V. All rights reserved.
    Original languageEnglish
    JournalImmunology Letters
    Issue number2
    Pages (from-to)131-135
    Number of pages5
    Publication statusPublished - 2008
    MoE publication typeA1 Journal article-refereed

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