Abstract
Objectives: The aim of this study was to describe a method for analysing histological fragments derived from fineneedle aspirate biopsy (FNAB) of salivary gland tumours (SGTs), and to evaluate the use of immunohistochemistry (IHC) on them. Study Design: We reviewed all 509 FNAB pathology reports taken from SGTs at Helsinki University Hospital, Finland, between 1999 and 2009. In 51% of the cases (n = 209) "histo-fragments" had been obtained and 31 had been further analysed by IHC. Of these, 25 (81%) were available for review. We evaluated the benefit of IHC by relating its added value to the preoperative cytological diagnosis and its accuracy compared with the postoperative histological diagnosis. Results: Most of the samples analysed by IHC were assigned a malignant diagnosis, with 12 different types of malignancy represented. IHC was advantageous in 76% of the cases. In the 108 studies using IHC in this series, antibodies to 36 different antigens were used. Conclusion: Analysis of histo-fragments in FNABs using IHC can be valuable in specific differential diagnostics and raises diagnostic accuracy in SGTs.
| Original language | English |
|---|---|
| Journal | Acta Cytologica |
| Volume | 61 |
| Issue number | 1 |
| Pages (from-to) | 17-20 |
| Number of pages | 4 |
| ISSN | 0001-5547 |
| DOIs | |
| Publication status | Published - 2017 |
| MoE publication type | A1 Journal article-refereed |
Fields of Science
- Salivary gland
- Head and neck neoplasms
- Fine-needle biopsy
- Fine-needle aspirate
- Immunohistochemistry
- Histo-fragment
- Histo-block
- Cell block
- CYTOLOGY
- LESIONS
- DIAGNOSIS
- ACCURACY
- EFFICACY
- 3111 Biomedicine