Impact of maternal height and gestational diabetes mellitus on offspring birthweight

Senja Masalin, Merja K. Laine, Hannu Kautiainen, Mika Gissler, Marko Raina, Pirjo Pennanen, Johan G. Eriksson

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Aims: To evaluate the impact of gestational diabetes mellitus (GDM) and maternal height on offspring birthweight.

Methods: This is an observational cohort study, encompassing 4 111 Finnish primiparous women from Vantaa city, Finland, with singleton deliveries between 2009 and 2015. Data were obtained from the Finnish Medical Birth Register. The study population was divided into five groups according to maternal height. Cut-offs for height levels were I = 173 cm. The main outcome measure was offspring birthweight, expressed as Z-scores according to sex and gestational age.

Results: Independently, both maternal height and GDM increased offspring birthweight (p <0.001 for height and GDM). When studying the interaction, a significant increase in offspring birthweight was noted only in extreme height categories; group I = 173 cm (p <0.001) and the impact was similar in both sexes. Maternal height had no impact on offspring ponderal index (p = 0.20 for trend).

Conclusions: In extreme height categories, short and tall primiparous women with GDM are at risk for delivering larger offspring compared to women without GDM of similar height. (C) 2019 Elsevier B.V. All rights reserved.

Original languageEnglish
JournalDiabetes Research and Clinical Practice
Volume148
Pages (from-to)110-118
Number of pages9
ISSN0168-8227
DOIs
Publication statusPublished - Feb 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Birthweight
  • FETAL-GROWTH
  • GLUCOSE-TOLERANCE
  • Gestational diabetes mellitus
  • HYPERGLYCEMIA
  • Maternal height
  • Offspring
  • Primiparous
  • RISK
  • SHORT STATURE
  • SIZE
  • Stature
  • 3121 Internal medicine

Cite this

Masalin, Senja ; Laine, Merja K. ; Kautiainen, Hannu ; Gissler, Mika ; Raina, Marko ; Pennanen, Pirjo ; Eriksson, Johan G. / Impact of maternal height and gestational diabetes mellitus on offspring birthweight. In: Diabetes Research and Clinical Practice. 2019 ; Vol. 148. pp. 110-118.
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author = "Senja Masalin and Laine, {Merja K.} and Hannu Kautiainen and Mika Gissler and Marko Raina and Pirjo Pennanen and Eriksson, {Johan G.}",
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Impact of maternal height and gestational diabetes mellitus on offspring birthweight. / Masalin, Senja; Laine, Merja K.; Kautiainen, Hannu; Gissler, Mika; Raina, Marko; Pennanen, Pirjo; Eriksson, Johan G.

In: Diabetes Research and Clinical Practice, Vol. 148, 02.2019, p. 110-118.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Masalin, Senja

AU - Laine, Merja K.

AU - Kautiainen, Hannu

AU - Gissler, Mika

AU - Raina, Marko

AU - Pennanen, Pirjo

AU - Eriksson, Johan G.

PY - 2019/2

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N2 - Aims: To evaluate the impact of gestational diabetes mellitus (GDM) and maternal height on offspring birthweight.Methods: This is an observational cohort study, encompassing 4 111 Finnish primiparous women from Vantaa city, Finland, with singleton deliveries between 2009 and 2015. Data were obtained from the Finnish Medical Birth Register. The study population was divided into five groups according to maternal height. Cut-offs for height levels were I = 173 cm. The main outcome measure was offspring birthweight, expressed as Z-scores according to sex and gestational age.Results: Independently, both maternal height and GDM increased offspring birthweight (p <0.001 for height and GDM). When studying the interaction, a significant increase in offspring birthweight was noted only in extreme height categories; group I = 173 cm (p <0.001) and the impact was similar in both sexes. Maternal height had no impact on offspring ponderal index (p = 0.20 for trend).Conclusions: In extreme height categories, short and tall primiparous women with GDM are at risk for delivering larger offspring compared to women without GDM of similar height. (C) 2019 Elsevier B.V. All rights reserved.

AB - Aims: To evaluate the impact of gestational diabetes mellitus (GDM) and maternal height on offspring birthweight.Methods: This is an observational cohort study, encompassing 4 111 Finnish primiparous women from Vantaa city, Finland, with singleton deliveries between 2009 and 2015. Data were obtained from the Finnish Medical Birth Register. The study population was divided into five groups according to maternal height. Cut-offs for height levels were I = 173 cm. The main outcome measure was offspring birthweight, expressed as Z-scores according to sex and gestational age.Results: Independently, both maternal height and GDM increased offspring birthweight (p <0.001 for height and GDM). When studying the interaction, a significant increase in offspring birthweight was noted only in extreme height categories; group I = 173 cm (p <0.001) and the impact was similar in both sexes. Maternal height had no impact on offspring ponderal index (p = 0.20 for trend).Conclusions: In extreme height categories, short and tall primiparous women with GDM are at risk for delivering larger offspring compared to women without GDM of similar height. (C) 2019 Elsevier B.V. All rights reserved.

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KW - HYPERGLYCEMIA

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