Impaired pre-attentive auditory processing in opioid dependence with and without benzodiazepine co-dependence revealed by combined magnetoencephalography and electroencephalography

Reetta Kivisaari, Reia Lehtinen, Taina Autti, Varpu Puuskari, Olga Jokela, Jyrki Ahveninen, Pekka Rapeli, Seppo Kähkönen

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Cognitive dysfunctions may be a significant factor in drug-seeking behavior, reducing the efficiency of rehabilitation in opioid dependence. Neurophysiological basis of these dysfunctions is poorly understood. 21 opioid-dependent patients and 15 healthy controls with no experience of illicit drugs were studied with simultaneous electroencephalography (EEG) and magnetoencephalography (MEG). Among opioid dependents 15 were benzodiazepine co-dependent. In a passive oddball paradigm, a train of 700-Hz standard tones (80%), presented to the left ear, was occasionally interrupted by infrequent deviants, which were either 600-Hz or 400-Hz pure tones or complex novel sounds. The auditory evoked potentials (AEP) and fields (AEF) were analyzed. The strength of the N 1m dipoles was enhanced in patients with benzodiazepine co-dependence, but the latency of the response or the source location was not changed. A delay of mismatch negativity (MNM) response of novel tones in EEG, and delay of P3am response on the contralateral hemisphere to stimulated ear in MEG in opioid-dependent patients were observed. There were no differences in source locations or strengths of the dipoles for P 1m, MMNm, and P3am determined using equivalent current dipoles. There were no group differences in EEG amplitude measures. In conclusion, our results suggest delayed pre-attentive auditory processing of novel information in opioid dependence. Benzodiazepine co-dependence modulated N1m response. (c) 2007 Elsevier Inc. All rights reserved.
Original languageEnglish
JournalProgress in Neuro-Psychopharmacology & Biological Psychiatry
Issue number7
Pages (from-to)1378-1386
Number of pages9
Publication statusPublished - 2007
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 311 Basic medicine
  • 312 Clinical medicine
  • 318 Medical biotechnology
  • 515 Psychology

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