Implications of melanin binding in ocular drug delivery

Anna-Kaisa Rimpelä; Mika Reinisalo; Laura Hellinen; Evgeni Grazhdankin; Heidi Kidron; Arto Urtti; Eva M. del Amo

doi:10.1016/j.addr.2017.12.008

Implications of melanin binding in ocular drug delivery

Anna-Kaisa Rimpelä, Mika Reinisalo, Laura Hellinen, Evgeni Grazhdankin, Heidi Kidron, Arto Urtti, Eva M. del Amo

Research output: Contribution to journal › Review Article › Scientific › peer-review

Original language	English
Journal	Advanced Drug Delivery Reviews
Volume	126
Pages (from-to)	23-43
Number of pages	21
ISSN	0169-409X
DOIs	https://doi.org/10.1016/j.addr.2017.12.008
Publication status	Published - 15 Feb 2018
MoE publication type	A2 Review article in a scientific journal

Fields of Science

Ocular melanin
Melanosomes
Pigment binding
Pharmacokinetics
Pharmacodynamics
Pharmacokinetic simulations
QSAR
RETINAL-PIGMENT-EPITHELIUM
PLURIPOTENT STEM-CELLS
HUMAN CHOROIDAL MELANOCYTES
WHOLE-BODY AUTORADIOGRAPHY
SYNTHETIC LEVODOPA MELANIN
IN-VITRO
UVEAL MELANOCYTES
5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID
TRANSSCLERAL DELIVERY
DOPA-MELANIN
317 Pharmacy

Access to Document

10.1016/j.addr.2017.12.008

Cite this

Rimpelä, A-K., Reinisalo, M., Hellinen, L., Grazhdankin, E., Kidron, H., Urtti, A., & del Amo, E. M. (2018). Implications of melanin binding in ocular drug delivery. Advanced Drug Delivery Reviews, 126, 23-43. https://doi.org/10.1016/j.addr.2017.12.008

@article{9467269e6779431ab60a90fe6d23dca0,

title = "Implications of melanin binding in ocular drug delivery",

keywords = "Ocular melanin, Melanosomes, Pigment binding, Pharmacokinetics, Pharmacodynamics, Pharmacokinetic simulations, QSAR, RETINAL-PIGMENT-EPITHELIUM, PLURIPOTENT STEM-CELLS, HUMAN CHOROIDAL MELANOCYTES, WHOLE-BODY AUTORADIOGRAPHY, SYNTHETIC LEVODOPA MELANIN, IN-VITRO, UVEAL MELANOCYTES, 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID, TRANSSCLERAL DELIVERY, DOPA-MELANIN, 317 Pharmacy",

author = "Anna-Kaisa Rimpel{\"a} and Mika Reinisalo and Laura Hellinen and Evgeni Grazhdankin and Heidi Kidron and Arto Urtti and {del Amo}, {Eva M.}",

year = "2018",

month = "2",

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doi = "10.1016/j.addr.2017.12.008",

language = "English",

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journal = "Advanced Drug Delivery Reviews",

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T1 - Implications of melanin binding in ocular drug delivery

AU - Rimpelä, Anna-Kaisa

AU - Reinisalo, Mika

AU - Hellinen, Laura

AU - Grazhdankin, Evgeni

AU - Kidron, Heidi

AU - Urtti, Arto

AU - del Amo, Eva M.

PY - 2018/2/15

Y1 - 2018/2/15

KW - Ocular melanin

KW - Melanosomes

KW - Pigment binding

KW - Pharmacokinetics

KW - Pharmacodynamics

KW - Pharmacokinetic simulations

KW - QSAR

KW - RETINAL-PIGMENT-EPITHELIUM

KW - PLURIPOTENT STEM-CELLS

KW - HUMAN CHOROIDAL MELANOCYTES

KW - WHOLE-BODY AUTORADIOGRAPHY

KW - SYNTHETIC LEVODOPA MELANIN

KW - IN-VITRO

KW - UVEAL MELANOCYTES

KW - 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID

KW - TRANSSCLERAL DELIVERY

KW - DOPA-MELANIN

KW - 317 Pharmacy

U2 - 10.1016/j.addr.2017.12.008

DO - 10.1016/j.addr.2017.12.008

M3 - Review Article

VL - 126

SP - 23

EP - 43

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

ER -