Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery

Research output: Contribution to journalReview Articlepeer-review

Original languageEnglish
JournalExpert opinion on drug discovery
Volume13
Issue number2
Pages (from-to)179-192
Number of pages14
ISSN1746-0441
DOIs
Publication statusPublished - 2018
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 317 Pharmacy
  • 3111 Biomedicine
  • Polypharmacology
  • efficacy-toxicity ratio
  • drug repositioning
  • multi-target drug design
  • profiling strategies
  • screening libraries
  • drug combination therapies
  • computational models
  • data resources
  • web-tools
  • TARGET INTERACTION NETWORKS
  • PROTEIN INVERSE DOCKING
  • LIGAND-BINDING-SITES
  • SIDE-EFFECT TARGETS
  • DE-NOVO DESIGN
  • WEB SERVER
  • COMPUTATIONAL METHODS
  • KINASE INHIBITOR
  • SMALL-MOLECULE
  • CANCER-CELLS

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