Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery

Research output: Contribution to journalReview ArticleScientificpeer-review

Original languageEnglish
JournalExpert opinion on drug discovery
Volume13
Issue number2
Pages (from-to)179-192
Number of pages14
ISSN1746-0441
DOIs
Publication statusPublished - 2018
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 317 Pharmacy
  • 3111 Biomedicine
  • Polypharmacology
  • efficacy-toxicity ratio
  • drug repositioning
  • multi-target drug design
  • profiling strategies
  • screening libraries
  • drug combination therapies
  • computational models
  • data resources
  • web-tools
  • TARGET INTERACTION NETWORKS
  • PROTEIN INVERSE DOCKING
  • LIGAND-BINDING-SITES
  • SIDE-EFFECT TARGETS
  • DE-NOVO DESIGN
  • WEB SERVER
  • COMPUTATIONAL METHODS
  • KINASE INHIBITOR
  • SMALL-MOLECULE
  • CANCER-CELLS

Cite this

@article{f221930a29f9445aa91d4d3d725a0bcd,
title = "Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery",
keywords = "317 Pharmacy, 3111 Biomedicine, Polypharmacology, efficacy-toxicity ratio, drug repositioning, multi-target drug design, profiling strategies, screening libraries, drug combination therapies, computational models, data resources, web-tools, TARGET INTERACTION NETWORKS, PROTEIN INVERSE DOCKING, LIGAND-BINDING-SITES, SIDE-EFFECT TARGETS, DE-NOVO DESIGN, WEB SERVER, COMPUTATIONAL METHODS, KINASE INHIBITOR, SMALL-MOLECULE, CANCER-CELLS",
author = "Balaguru Ravikumar and Tero Aittokallio",
year = "2018",
doi = "10.1080/17460441.2018.1413089",
language = "English",
volume = "13",
pages = "179--192",
journal = "Expert opinion on drug discovery",
issn = "1746-0441",
publisher = "Taylor & Francis",
number = "2",

}

Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery. / Ravikumar, Balaguru; Aittokallio, Tero.

In: Expert opinion on drug discovery, Vol. 13, No. 2, 2018, p. 179-192.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery

AU - Ravikumar, Balaguru

AU - Aittokallio, Tero

PY - 2018

Y1 - 2018

KW - 317 Pharmacy

KW - 3111 Biomedicine

KW - Polypharmacology

KW - efficacy-toxicity ratio

KW - drug repositioning

KW - multi-target drug design

KW - profiling strategies

KW - screening libraries

KW - drug combination therapies

KW - computational models

KW - data resources

KW - web-tools

KW - TARGET INTERACTION NETWORKS

KW - PROTEIN INVERSE DOCKING

KW - LIGAND-BINDING-SITES

KW - SIDE-EFFECT TARGETS

KW - DE-NOVO DESIGN

KW - WEB SERVER

KW - COMPUTATIONAL METHODS

KW - KINASE INHIBITOR

KW - SMALL-MOLECULE

KW - CANCER-CELLS

U2 - 10.1080/17460441.2018.1413089

DO - 10.1080/17460441.2018.1413089

M3 - Review Article

VL - 13

SP - 179

EP - 192

JO - Expert opinion on drug discovery

JF - Expert opinion on drug discovery

SN - 1746-0441

IS - 2

ER -