In Vitro Assessment of Time-Dependent Inhibitory Effects on CYP2C8 and CYP3A Activity by Fourteen Protein Kinase Inhibitors

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalDrug Metabolism and Disposition
Volume42
Issue number7
Pages (from-to)1202-1209
Number of pages8
ISSN0090-9556
DOIs
Publication statusPublished - Jul 2014
MoE publication typeA1 Journal article-refereed

Fields of Science

  • DRUG-DRUG INTERACTIONS
  • HUMAN CYTOCHROME-P450 ENZYMES
  • MECHANISM-BASED INACTIVATION
  • HUMAN LIVER-MICROSOMES
  • PLASMA-CONCENTRATIONS
  • CLINICAL PHARMACOKINETICS
  • BIOACTIVATION PATHWAYS
  • SOLID TUMORS
  • PHASE-I
  • GEMFIBROZIL
  • 3111 Biomedicine

Cite this

@article{0df2c457bd6543d59bbab5e1f16b9387,
title = "In Vitro Assessment of Time-Dependent Inhibitory Effects on CYP2C8 and CYP3A Activity by Fourteen Protein Kinase Inhibitors",
keywords = "DRUG-DRUG INTERACTIONS, HUMAN CYTOCHROME-P450 ENZYMES, MECHANISM-BASED INACTIVATION, HUMAN LIVER-MICROSOMES, PLASMA-CONCENTRATIONS, CLINICAL PHARMACOKINETICS, BIOACTIVATION PATHWAYS, SOLID TUMORS, PHASE-I, GEMFIBROZIL, 3111 Biomedicine",
author = "Filppula, {Anne M.} and Neuvonen, {Pertti J.} and Backman, {Janne T.}",
year = "2014",
month = "7",
doi = "10.1124/dmd.114.057695",
language = "English",
volume = "42",
pages = "1202--1209",
journal = "Drug Metabolism and Disposition",
issn = "1521-009X",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "7",

}

TY - JOUR

T1 - In Vitro Assessment of Time-Dependent Inhibitory Effects on CYP2C8 and CYP3A Activity by Fourteen Protein Kinase Inhibitors

AU - Filppula, Anne M.

AU - Neuvonen, Pertti J.

AU - Backman, Janne T.

PY - 2014/7

Y1 - 2014/7

KW - DRUG-DRUG INTERACTIONS

KW - HUMAN CYTOCHROME-P450 ENZYMES

KW - MECHANISM-BASED INACTIVATION

KW - HUMAN LIVER-MICROSOMES

KW - PLASMA-CONCENTRATIONS

KW - CLINICAL PHARMACOKINETICS

KW - BIOACTIVATION PATHWAYS

KW - SOLID TUMORS

KW - PHASE-I

KW - GEMFIBROZIL

KW - 3111 Biomedicine

U2 - 10.1124/dmd.114.057695

DO - 10.1124/dmd.114.057695

M3 - Article

VL - 42

SP - 1202

EP - 1209

JO - Drug Metabolism and Disposition

JF - Drug Metabolism and Disposition

SN - 1521-009X

IS - 7

ER -