In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4

Possible Implications with regard to Drug-Drug Interactions

Anne M. Filppula, Tiffany M. Mustonen, Janne T. Backman

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalBasic & Clinical Pharmacology & Toxicology
Volume123
Issue number6
Pages (from-to)739-748
Number of pages10
ISSN1742-7835
DOIs
Publication statusPublished - Dec 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • MECHANISM-BASED INACTIVATION
  • ADVANCED SOLID TUMORS
  • BIOACTIVATION PATHWAYS
  • CYTOCHROME-P450 3A4
  • MYELOID-LEUKEMIA
  • LIVER-MICROSOMES
  • GRAPEFRUIT JUICE
  • BIBF 1120
  • PHASE-II
  • PREDICTION
  • 317 Pharmacy
  • 3111 Biomedicine

Cite this

@article{792804a45a1e46129d98b0d7ff8a4764,
title = "In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug-Drug Interactions",
keywords = "MECHANISM-BASED INACTIVATION, ADVANCED SOLID TUMORS, BIOACTIVATION PATHWAYS, CYTOCHROME-P450 3A4, MYELOID-LEUKEMIA, LIVER-MICROSOMES, GRAPEFRUIT JUICE, BIBF 1120, PHASE-II, PREDICTION, 317 Pharmacy, 3111 Biomedicine",
author = "Filppula, {Anne M.} and Mustonen, {Tiffany M.} and Backman, {Janne T.}",
year = "2018",
month = "12",
doi = "10.1111/bcpt.13088",
language = "English",
volume = "123",
pages = "739--748",
journal = "Basic & Clinical Pharmacology & Toxicology",
issn = "1742-7835",
publisher = "Wiley",
number = "6",

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TY - JOUR

T1 - In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4

T2 - Possible Implications with regard to Drug-Drug Interactions

AU - Filppula, Anne M.

AU - Mustonen, Tiffany M.

AU - Backman, Janne T.

PY - 2018/12

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KW - MECHANISM-BASED INACTIVATION

KW - ADVANCED SOLID TUMORS

KW - BIOACTIVATION PATHWAYS

KW - CYTOCHROME-P450 3A4

KW - MYELOID-LEUKEMIA

KW - LIVER-MICROSOMES

KW - GRAPEFRUIT JUICE

KW - BIBF 1120

KW - PHASE-II

KW - PREDICTION

KW - 317 Pharmacy

KW - 3111 Biomedicine

U2 - 10.1111/bcpt.13088

DO - 10.1111/bcpt.13088

M3 - Article

VL - 123

SP - 739

EP - 748

JO - Basic & Clinical Pharmacology & Toxicology

JF - Basic & Clinical Pharmacology & Toxicology

SN - 1742-7835

IS - 6

ER -