Incidence of lichen sclerosus and subsequent causes of death: a nationwide Finnish register study

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Abstract Objective To assess the incidence of lichen sclerosus (LS) in women and all-cause and cause-specific mortality of women with LS. Design Population-based descriptive study. Setting Finland. Population All Finnish women, including 7,790 women diagnosed with LS during 1969-2012. Methods Information gathered from the national Hospital Discharge Registry on women with LS is combined with dates and causes of death from Statistics Finland and Finnish Cancer Registry. Population statistics are from Statistics Finland. Main Outcome Measures Crude and age-adjusted incidence rates of LS and standardized mortality ratios (SMR). Results The incidence rate of LS adjusted for age (European Standard Population) increased from 14 per 100,000 woman-years in 2003 to 22 per 100,000 woman-years in 2010-2012. The age-specific incidence rate was highest in postmenopausal women (24-53 per 100,000), and was also elevated in girls in ages of 5-9 (7 per 100,000). All-cause mortality of women with LS was lower than in the general female population (SMR 0.84, 95% confidence interval [95% CI] 0.78-0.90), mostly due to decreased mortality from circulatory diseases (SMR 0.80, 95% CI 0.72-0.89), and dementia and Alzheimer?s disease (SMR 0.75, 95% CI 0.62-0.88). Cancer mortality equaled that of the population, but vulvar cancer mortality was increased (SMR 28.1, 95% CI 19.3-39.4). Conclusions LS is a common disease of elderly women. The overall mortality is decreased whereas mortality due to vulvar cancer is increased.
Original languageEnglish
JournalBJOG : An International Journal of Obstetrics & Gynaecology
Issue numbern/a
Publication statusPublished - 17 Feb 2020
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Lichen sclerosus
  • incidence
  • mortality
  • cause of death
  • epidemiology
  • prognosis
  • 3123 Gynaecology and paediatrics

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