Abstract

Whether infant regulatory behavior problems already in the first month of life indicate an increased risk of childhood neurobehavioral problems, and whether maternal depression in the postpartum and early childhood underpins these associations remain unclear. Altogether, 2049-2364 mothers from the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction (PREDO) study completed the Neonatal Perception Inventory on regulatory behavior problems at the infant's age of 15.6 days (SD 3.2, range 1-30), the Infant Behavior Questionnaire-Revised on temperament at 6.5 months (SD 0.9, range 4.2-12.4), and the Ages and Stages Questionnaire-3 on developmental milestones and the Child Behavior Checklist on behavioral problems at 3.5 years (SD 0.7, range 1.9-6.0). Maternal depressive symptoms were measured by the Center for Epidemiological Studies Depression Scale (infancy follow-ups) and Beck Depression Inventory-II (childhood follow-up). Father-rated infant temperament and paternal depressive symptoms were also available (n = 1474). Higher levels of infant regulatory behavior problems predicted higher levels of mother- and father-rated negative affectivity temperament (0.13 SD units per SD unit, 95% confidence interval 0.09-0.17; and 0.09, 0.04-0.14, respectively), lower levels of mother-rated orienting/regulation temperament (- 0.09, - 0.13 to - 0.05) and problem-solving skills (- 0.12, - 0.21 to - 0.04), and higher levels of Externalizing (0.07, 0.03-0.11) and Total behavioral problems (0.07, 0.03-0.11). Regulatory behaviors partially mediated the effect of maternal depressive symptoms. Regulatory behavior problems already during the first month of life predict neurobehavioral outcomes, and partially mediate the effect of maternal depressive symptoms. Our study may inform design of interventions aimed at timely prevention in children at risk.
Original languageEnglish
JournalEuropean Child & Adolescent Psychiatry
Volume28
Issue number6
Pages (from-to)847-859
Number of pages13
ISSN1018-8827
DOIs
Publication statusPublished - Jun 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 3124 Neurology and psychiatry
  • 515 Psychology
  • Regulatory behavior
  • Infant
  • Depressive symptoms
  • Temperament
  • Neurobehavioral outcomes
  • MATERNAL DEPRESSION
  • FEEDING PROBLEMS
  • CHILDREN BORN
  • AGE
  • TEMPERAMENT
  • DISORDERS
  • SYMPTOMS
  • VALIDITY
  • STRESS
  • RISK

Cite this

@article{a0fed6c0a10149e8b193d5c674eeb54d,
title = "Infant regulatory behavior problems during first month of life and neurobehavioral outcomes in early childhood.",
abstract = "Whether infant regulatory behavior problems already in the first month of life indicate an increased risk of childhood neurobehavioral problems, and whether maternal depression in the postpartum and early childhood underpins these associations remain unclear. Altogether, 2049-2364 mothers from the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction (PREDO) study completed the Neonatal Perception Inventory on regulatory behavior problems at the infant's age of 15.6 days (SD 3.2, range 1-30), the Infant Behavior Questionnaire-Revised on temperament at 6.5 months (SD 0.9, range 4.2-12.4), and the Ages and Stages Questionnaire-3 on developmental milestones and the Child Behavior Checklist on behavioral problems at 3.5 years (SD 0.7, range 1.9-6.0). Maternal depressive symptoms were measured by the Center for Epidemiological Studies Depression Scale (infancy follow-ups) and Beck Depression Inventory-II (childhood follow-up). Father-rated infant temperament and paternal depressive symptoms were also available (n = 1474). Higher levels of infant regulatory behavior problems predicted higher levels of mother- and father-rated negative affectivity temperament (0.13 SD units per SD unit, 95{\%} confidence interval 0.09-0.17; and 0.09, 0.04-0.14, respectively), lower levels of mother-rated orienting/regulation temperament (- 0.09, - 0.13 to - 0.05) and problem-solving skills (- 0.12, - 0.21 to - 0.04), and higher levels of Externalizing (0.07, 0.03-0.11) and Total behavioral problems (0.07, 0.03-0.11). Regulatory behaviors partially mediated the effect of maternal depressive symptoms. Regulatory behavior problems already during the first month of life predict neurobehavioral outcomes, and partially mediate the effect of maternal depressive symptoms. Our study may inform design of interventions aimed at timely prevention in children at risk.",
keywords = "3124 Neurology and psychiatry, 515 Psychology, Regulatory behavior, Infant, Depressive symptoms, Temperament, Neurobehavioral outcomes, MATERNAL DEPRESSION, FEEDING PROBLEMS, CHILDREN BORN, AGE, TEMPERAMENT, DISORDERS, SYMPTOMS, VALIDITY, STRESS, RISK",
author = "Elena Toffol and Ville Rantalainen and Marius Lahti-Pulkkinen and Polina Girchenko and Jari Lahti and Soile Tuovinen and Jari Lipsanen and Villa, {Pia M.} and Hannele Laivuori and Esa H{\"a}m{\"a}l{\"a}inen and Eero Kajantie and Katri R{\"a}ikk{\"o}nen",
year = "2019",
month = "6",
doi = "10.1007/s00787-018-1243-8",
language = "English",
volume = "28",
pages = "847--859",
journal = "European Child & Adolescent Psychiatry",
issn = "1018-8827",
publisher = "Springer",
number = "6",

}

TY - JOUR

T1 - Infant regulatory behavior problems during first month of life and neurobehavioral outcomes in early childhood.

AU - Toffol, Elena

AU - Rantalainen, Ville

AU - Lahti-Pulkkinen, Marius

AU - Girchenko, Polina

AU - Lahti, Jari

AU - Tuovinen, Soile

AU - Lipsanen, Jari

AU - Villa, Pia M.

AU - Laivuori, Hannele

AU - Hämäläinen, Esa

AU - Kajantie, Eero

AU - Räikkönen, Katri

PY - 2019/6

Y1 - 2019/6

N2 - Whether infant regulatory behavior problems already in the first month of life indicate an increased risk of childhood neurobehavioral problems, and whether maternal depression in the postpartum and early childhood underpins these associations remain unclear. Altogether, 2049-2364 mothers from the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction (PREDO) study completed the Neonatal Perception Inventory on regulatory behavior problems at the infant's age of 15.6 days (SD 3.2, range 1-30), the Infant Behavior Questionnaire-Revised on temperament at 6.5 months (SD 0.9, range 4.2-12.4), and the Ages and Stages Questionnaire-3 on developmental milestones and the Child Behavior Checklist on behavioral problems at 3.5 years (SD 0.7, range 1.9-6.0). Maternal depressive symptoms were measured by the Center for Epidemiological Studies Depression Scale (infancy follow-ups) and Beck Depression Inventory-II (childhood follow-up). Father-rated infant temperament and paternal depressive symptoms were also available (n = 1474). Higher levels of infant regulatory behavior problems predicted higher levels of mother- and father-rated negative affectivity temperament (0.13 SD units per SD unit, 95% confidence interval 0.09-0.17; and 0.09, 0.04-0.14, respectively), lower levels of mother-rated orienting/regulation temperament (- 0.09, - 0.13 to - 0.05) and problem-solving skills (- 0.12, - 0.21 to - 0.04), and higher levels of Externalizing (0.07, 0.03-0.11) and Total behavioral problems (0.07, 0.03-0.11). Regulatory behaviors partially mediated the effect of maternal depressive symptoms. Regulatory behavior problems already during the first month of life predict neurobehavioral outcomes, and partially mediate the effect of maternal depressive symptoms. Our study may inform design of interventions aimed at timely prevention in children at risk.

AB - Whether infant regulatory behavior problems already in the first month of life indicate an increased risk of childhood neurobehavioral problems, and whether maternal depression in the postpartum and early childhood underpins these associations remain unclear. Altogether, 2049-2364 mothers from the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction (PREDO) study completed the Neonatal Perception Inventory on regulatory behavior problems at the infant's age of 15.6 days (SD 3.2, range 1-30), the Infant Behavior Questionnaire-Revised on temperament at 6.5 months (SD 0.9, range 4.2-12.4), and the Ages and Stages Questionnaire-3 on developmental milestones and the Child Behavior Checklist on behavioral problems at 3.5 years (SD 0.7, range 1.9-6.0). Maternal depressive symptoms were measured by the Center for Epidemiological Studies Depression Scale (infancy follow-ups) and Beck Depression Inventory-II (childhood follow-up). Father-rated infant temperament and paternal depressive symptoms were also available (n = 1474). Higher levels of infant regulatory behavior problems predicted higher levels of mother- and father-rated negative affectivity temperament (0.13 SD units per SD unit, 95% confidence interval 0.09-0.17; and 0.09, 0.04-0.14, respectively), lower levels of mother-rated orienting/regulation temperament (- 0.09, - 0.13 to - 0.05) and problem-solving skills (- 0.12, - 0.21 to - 0.04), and higher levels of Externalizing (0.07, 0.03-0.11) and Total behavioral problems (0.07, 0.03-0.11). Regulatory behaviors partially mediated the effect of maternal depressive symptoms. Regulatory behavior problems already during the first month of life predict neurobehavioral outcomes, and partially mediate the effect of maternal depressive symptoms. Our study may inform design of interventions aimed at timely prevention in children at risk.

KW - 3124 Neurology and psychiatry

KW - 515 Psychology

KW - Regulatory behavior

KW - Infant

KW - Depressive symptoms

KW - Temperament

KW - Neurobehavioral outcomes

KW - MATERNAL DEPRESSION

KW - FEEDING PROBLEMS

KW - CHILDREN BORN

KW - AGE

KW - TEMPERAMENT

KW - DISORDERS

KW - SYMPTOMS

KW - VALIDITY

KW - STRESS

KW - RISK

U2 - 10.1007/s00787-018-1243-8

DO - 10.1007/s00787-018-1243-8

M3 - Article

VL - 28

SP - 847

EP - 859

JO - European Child & Adolescent Psychiatry

JF - European Child & Adolescent Psychiatry

SN - 1018-8827

IS - 6

ER -