Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis

Rainer Krebs; Jussi M. Tikkanen; Alireza Raissadati; Maria Hollmen; Kishor Dhaygude; Karl B. Lemstrom

doi:10.1016/j.ajpath.2021.10.018

Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis

Rainer Krebs, Jussi M. Tikkanen, Alireza Raissadati, Maria Hollmen, Kishor Dhaygude, Karl B. Lemstrom

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	The American Journal of Pathology
Volume	192
Issue number	2
Pages (from-to)	254-269
Number of pages	16
ISSN	0002-9440
DOIs	https://doi.org/10.1016/j.ajpath.2021.10.018
Publication status	Published - Feb 2022
MoE publication type	A1 Journal article-refereed

Bibliographical note

Funding Information:
Supported by the Helsinki University Hospital , the Sigrid Juselius Foundation , the Academy of Finland , Finska Läkaresällskapet , the Research and Science Foundation of Farmos , The Paulo Foundation , Jalmari and Rauha Ahokas Foundation , Aarne Koskelo Foundation , Päivi and Sakari Sohlberg Foundation , Finnish Pulmonary Association , Biomedicum Helsinki Foundation , Jane and Aatos Erkko Foundation , and the University of Helsinki .

Funding Information:
Supported by the Helsinki University Hospital, the Sigrid Juselius Foundation, the Academy of Finland, Finska L?kares?llskapet, the Research and Science Foundation of Farmos, The Paulo Foundation, Jalmari and Rauha Ahokas Foundation, Aarne Koskelo Foundation, P?ivi and Sakari Sohlberg Foundation, Finnish Pulmonary Association, Biomedicum Helsinki Foundation, Jane and Aatos Erkko Foundation, and the University of Helsinki.

Publisher Copyright:
© 2022 American Society for Investigative Pathology

Fields of Science

PERIPHERAL-BLOOD
T-CELLS
RHEUMATOID-ARTHRITIS
CHEMOKINE RECEPTOR
CHRONIC REJECTION
FACTOR EXPRESSION
TYROSINE KINASE
AIRWAY DISEASE
CXC CHEMOKINES
TH17 CELLS
3111 Biomedicine

Access to Document

10.1016/j.ajpath.2021.10.018

PIIS0002944021004752Final published version, 3.2 MBLicence: CC BY

Cite this

Krebs, R., Tikkanen, J. M., Raissadati, A., Hollmen, M., Dhaygude, K., & Lemstrom, K. B. (2022). Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis. The American Journal of Pathology, 192(2), 254-269. https://doi.org/10.1016/j.ajpath.2021.10.018

@article{0ee1c45f1f7a436cb974207ec715ccaa,

title = "Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis",

keywords = "PERIPHERAL-BLOOD, T-CELLS, RHEUMATOID-ARTHRITIS, CHEMOKINE RECEPTOR, CHRONIC REJECTION, FACTOR EXPRESSION, TYROSINE KINASE, AIRWAY DISEASE, CXC CHEMOKINES, TH17 CELLS, 3111 Biomedicine",

author = "Rainer Krebs and Tikkanen, {Jussi M.} and Alireza Raissadati and Maria Hollmen and Kishor Dhaygude and Lemstrom, {Karl B.}",

note = "Funding Information: Supported by the Helsinki University Hospital , the Sigrid Juselius Foundation , the Academy of Finland , Finska L{\"a}kares{\"a}llskapet , the Research and Science Foundation of Farmos , The Paulo Foundation , Jalmari and Rauha Ahokas Foundation , Aarne Koskelo Foundation , P{\"a}ivi and Sakari Sohlberg Foundation , Finnish Pulmonary Association , Biomedicum Helsinki Foundation , Jane and Aatos Erkko Foundation , and the University of Helsinki . Funding Information: Supported by the Helsinki University Hospital, the Sigrid Juselius Foundation, the Academy of Finland, Finska L?kares?llskapet, the Research and Science Foundation of Farmos, The Paulo Foundation, Jalmari and Rauha Ahokas Foundation, Aarne Koskelo Foundation, P?ivi and Sakari Sohlberg Foundation, Finnish Pulmonary Association, Biomedicum Helsinki Foundation, Jane and Aatos Erkko Foundation, and the University of Helsinki. Publisher Copyright: {\textcopyright} 2022 American Society for Investigative Pathology",

year = "2022",

month = feb,

doi = "10.1016/j.ajpath.2021.10.018",

language = "English",

volume = "192",

pages = "254--269",

journal = "The American Journal of Pathology",

issn = "0002-9440",

publisher = "Elsevier Inc. ",

number = "2",

}

Krebs, R, Tikkanen, JM , Raissadati, A , Hollmen, M , Dhaygude, K & Lemstrom, KB 2022, 'Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis', The American Journal of Pathology, vol. 192, no. 2, pp. 254-269. https://doi.org/10.1016/j.ajpath.2021.10.018

Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis. / Krebs, Rainer; Tikkanen, Jussi M.; Raissadati, Alireza et al.
In: The American Journal of Pathology, Vol. 192, No. 2, 02.2022, p. 254-269.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis

AU - Krebs, Rainer

AU - Tikkanen, Jussi M.

AU - Raissadati, Alireza

AU - Hollmen, Maria

AU - Dhaygude, Kishor

AU - Lemstrom, Karl B.

N1 - Funding Information: Supported by the Helsinki University Hospital , the Sigrid Juselius Foundation , the Academy of Finland , Finska Läkaresällskapet , the Research and Science Foundation of Farmos , The Paulo Foundation , Jalmari and Rauha Ahokas Foundation , Aarne Koskelo Foundation , Päivi and Sakari Sohlberg Foundation , Finnish Pulmonary Association , Biomedicum Helsinki Foundation , Jane and Aatos Erkko Foundation , and the University of Helsinki . Funding Information: Supported by the Helsinki University Hospital, the Sigrid Juselius Foundation, the Academy of Finland, Finska L?kares?llskapet, the Research and Science Foundation of Farmos, The Paulo Foundation, Jalmari and Rauha Ahokas Foundation, Aarne Koskelo Foundation, P?ivi and Sakari Sohlberg Foundation, Finnish Pulmonary Association, Biomedicum Helsinki Foundation, Jane and Aatos Erkko Foundation, and the University of Helsinki. Publisher Copyright: © 2022 American Society for Investigative Pathology

PY - 2022/2

Y1 - 2022/2

KW - PERIPHERAL-BLOOD

KW - T-CELLS

KW - RHEUMATOID-ARTHRITIS

KW - CHEMOKINE RECEPTOR

KW - CHRONIC REJECTION

KW - FACTOR EXPRESSION

KW - TYROSINE KINASE

KW - AIRWAY DISEASE

KW - CXC CHEMOKINES

KW - TH17 CELLS

KW - 3111 Biomedicine

UR - http://www.scopus.com/inward/record.url?scp=85124077502&partnerID=8YFLogxK

U2 - 10.1016/j.ajpath.2021.10.018

DO - 10.1016/j.ajpath.2021.10.018

M3 - Article

C2 - 34774518

SN - 0002-9440

VL - 192

SP - 254

EP - 269

JO - The American Journal of Pathology

JF - The American Journal of Pathology

IS - 2

ER -

Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis

Bibliographical note

Fields of Science

Access to Document

Other files and links

Cite this