Innate immunity and vaccines in chlamydial infection with special emphasis on Chlamydia pneumoniae

Mirja Puolakkainen

doi:10.1111/j.1574-695X.2008.00519.x

Innate immunity and vaccines in chlamydial infection with special emphasis on Chlamydia pneumoniae

Mirja Puolakkainen

Department of Virology

Research output: Contribution to journal › Review Article › peer-review

Abstract

Chlamydial infections are prevalent worldwide. Immunological events related to both innate and adaptive immunity during chlamydial infection can aid in recovery from the disease, but they can also cause harmful effects (immunopathology). The host genetic factors (variation in innate immunity and adaptive response-related genes) can predispose individuals to infection and its sequelae as well as determine the effects of intervention. No effective vaccine is available for human use. Modern technologies and data obtained using different 'omics' techniques (genomics, proteomics, transcriptomics and immunomics) might help in designing novel, more efficient vaccines, hopefully also against chlamydial infections.

Original language	English
Journal	FEMS Immunology and Medical Microbiology
Volume	55
Issue number	2
Pages (from-to)	167-177
Number of pages	11
ISSN	0928-8244
DOIs	https://doi.org/10.1111/j.1574-695X.2008.00519.x
Publication status	Published - 2009
MoE publication type	A2 Review article in a scientific journal

Fields of Science

Chlamydia pneumoniae
innate immunity
vaccine
Toll-like receptor
TOLL-LIKE RECEPTOR-2
MANNOSE-BINDING-LECTIN
OBLIGATE INTRACELLULAR PATHOGEN
EPITHELIAL-CELL PROLIFERATION
VASCULAR SMOOTH-MUSCLE
NOD-LIKE RECEPTORS
NF-KAPPA-B
IFN-GAMMA
MOUSE MACROPHAGES
TRACHOMATIS INFECTION
311 Basic medicine

Access to Document

10.1111/j.1574-695X.2008.00519.x

Cite this

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title = "Innate immunity and vaccines in chlamydial infection with special emphasis on Chlamydia pneumoniae",

abstract = "Chlamydial infections are prevalent worldwide. Immunological events related to both innate and adaptive immunity during chlamydial infection can aid in recovery from the disease, but they can also cause harmful effects (immunopathology). The host genetic factors (variation in innate immunity and adaptive response-related genes) can predispose individuals to infection and its sequelae as well as determine the effects of intervention. No effective vaccine is available for human use. Modern technologies and data obtained using different 'omics' techniques (genomics, proteomics, transcriptomics and immunomics) might help in designing novel, more efficient vaccines, hopefully also against chlamydial infections.",

keywords = "Chlamydia pneumoniae, innate immunity, vaccine, Toll-like receptor, TOLL-LIKE RECEPTOR-2, MANNOSE-BINDING-LECTIN, OBLIGATE INTRACELLULAR PATHOGEN, EPITHELIAL-CELL PROLIFERATION, VASCULAR SMOOTH-MUSCLE, NOD-LIKE RECEPTORS, NF-KAPPA-B, IFN-GAMMA, MOUSE MACROPHAGES, TRACHOMATIS INFECTION, 311 Basic medicine",

author = "Mirja Puolakkainen",

year = "2009",

doi = "10.1111/j.1574-695X.2008.00519.x",

language = "English",

volume = "55",

pages = "167--177",

journal = "FEMS Immunology and Medical Microbiology",

issn = "0928-8244",

publisher = "Wiley Blackwell",

number = "2",

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TY - JOUR

T1 - Innate immunity and vaccines in chlamydial infection with special emphasis on Chlamydia pneumoniae

AU - Puolakkainen, Mirja

PY - 2009

Y1 - 2009

N2 - Chlamydial infections are prevalent worldwide. Immunological events related to both innate and adaptive immunity during chlamydial infection can aid in recovery from the disease, but they can also cause harmful effects (immunopathology). The host genetic factors (variation in innate immunity and adaptive response-related genes) can predispose individuals to infection and its sequelae as well as determine the effects of intervention. No effective vaccine is available for human use. Modern technologies and data obtained using different 'omics' techniques (genomics, proteomics, transcriptomics and immunomics) might help in designing novel, more efficient vaccines, hopefully also against chlamydial infections.

AB - Chlamydial infections are prevalent worldwide. Immunological events related to both innate and adaptive immunity during chlamydial infection can aid in recovery from the disease, but they can also cause harmful effects (immunopathology). The host genetic factors (variation in innate immunity and adaptive response-related genes) can predispose individuals to infection and its sequelae as well as determine the effects of intervention. No effective vaccine is available for human use. Modern technologies and data obtained using different 'omics' techniques (genomics, proteomics, transcriptomics and immunomics) might help in designing novel, more efficient vaccines, hopefully also against chlamydial infections.

KW - Chlamydia pneumoniae

KW - innate immunity

KW - vaccine

KW - Toll-like receptor

KW - TOLL-LIKE RECEPTOR-2

KW - MANNOSE-BINDING-LECTIN

KW - OBLIGATE INTRACELLULAR PATHOGEN

KW - EPITHELIAL-CELL PROLIFERATION

KW - VASCULAR SMOOTH-MUSCLE

KW - NOD-LIKE RECEPTORS

KW - NF-KAPPA-B

KW - IFN-GAMMA

KW - MOUSE MACROPHAGES

KW - TRACHOMATIS INFECTION

KW - 311 Basic medicine

U2 - 10.1111/j.1574-695X.2008.00519.x

DO - 10.1111/j.1574-695X.2008.00519.x

M3 - Review Article

SN - 0928-8244

VL - 55

SP - 167

EP - 177

JO - FEMS Immunology and Medical Microbiology

JF - FEMS Immunology and Medical Microbiology

IS - 2

ER -