Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions

Kristian Semjonov, Maia Salm, Tiina Lipiäinen, Karin Kogermann, Andres Lust, Ivo Laidmäe, Osmo Antikainen, Clare J. Strachan, Henrik Ehlers, Jouko Yliruusi, Jyrki Heinämäki

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalInternational Journal of Pharmaceutics
Volume541
Issue number1-2
Pages (from-to)188-197
Number of pages10
ISSN0378-5173
DOIs
Publication statusPublished - 25 Apr 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • particle properties
  • bulk powder behavior
  • dissolution
  • solid dispersion
  • polymer
  • HOT-MELT EXTRUSION
  • WATER-SOLUBLE DRUG
  • AMORPHOUS INDOMETHACIN
  • DISSOLUTION RATE
  • PHYSICAL STABILITY
  • MIXTURES
  • SIZE
  • BIOAVAILABILITY
  • FLOWABILITY
  • FORMULATION
  • 317 Pharmacy

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