Intrahost Monkeypox Virus Genome Variation in Patient with Early Infection, Finland, 2022

Hanna Vauhkonen; Hannimari Kallio-Kokko; Eija Hiltunen-Back; Lasse  Lönnqvist; Jaana Leppäaho-Lakka; Laura Mannonen; Ravi Kant; Tarja Sironen; Satu Kurkela; Maija Lappalainen; Tomaž Mark Zorec; Samo Zakotnik; Doroteja  Vlaj; Miša  Korva; Tatjana  Avšič-Županc; Mario  Poljak; Teemu Smura; Olli Vapalahti

doi:10.3201/eid2903.221388

Intrahost Monkeypox Virus Genome Variation in Patient with Early Infection, Finland, 2022

Hanna Vauhkonen, Hannimari Kallio-Kokko, Eija Hiltunen-Back, Lasse Lönnqvist, Jaana Leppäaho-Lakka, Laura Mannonen, Ravi Kant, Tarja Sironen, Satu Kurkela, Maija Lappalainen, Tomaž Mark Zorec, Samo Zakotnik, Doroteja Vlaj, Miša Korva, Tatjana Avšič-Županc, Mario Poljak, Teemu Smura, Olli Vapalahti

Research output: Contribution to journal › Letter › Scientific › peer-review

Abstract

Monkeypox virus was imported into Finland during late May–early June 2022. Intrahost viral genome variation in a sample from 1 patient comprised a major variant with 3 lineage B.1.3–specific mutations and a minor variant with ancestral B.1 nucleotides. Results suggest either ongoing APOBEC3 enzyme–mediated evolution or co-infection.

Original language	English
Journal	Emerging Infectious Diseases
Volume	29
Issue number	3
Pages (from-to)	649-652
Number of pages	4
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid2903.221388
Publication status	Published - Mar 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

11832 Microbiology and virology
3141 Health care science

Access to Document

10.3201/eid2903.221388Licence: CC BY

22-1388Final published version, 1.08 MBLicence: CC BY

Cite this

Vauhkonen, H., Kallio-Kokko, H., Hiltunen-Back, E., Lönnqvist, L., Leppäaho-Lakka, J., Mannonen, L., Kant, R., Sironen, T., Kurkela, S., Lappalainen, M., Zorec, T. M., Zakotnik, S., Vlaj, D., Korva, M., Avšič-Županc, T., Poljak, M., Smura, T., & Vapalahti, O. (2023). Intrahost Monkeypox Virus Genome Variation in Patient with Early Infection, Finland, 2022. Emerging Infectious Diseases, 29(3), 649-652. https://doi.org/10.3201/eid2903.221388

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title = "Intrahost Monkeypox Virus Genome Variation in Patient with Early Infection, Finland, 2022",

abstract = "Monkeypox virus was imported into Finland during late May–early June 2022. Intrahost viral genome variation in a sample from 1 patient comprised a major variant with 3 lineage B.1.3–specific mutations and a minor variant with ancestral B.1 nucleotides. Results suggest either ongoing APOBEC3 enzyme–mediated evolution or co-infection.",

keywords = "11832 Microbiology and virology, 3141 Health care science",

author = "Hanna Vauhkonen and Hannimari Kallio-Kokko and Eija Hiltunen-Back and Lasse L{\"o}nnqvist and Jaana Lepp{\"a}aho-Lakka and Laura Mannonen and Ravi Kant and Tarja Sironen and Satu Kurkela and Maija Lappalainen and Zorec, {Toma{\v z} Mark} and Samo Zakotnik and Doroteja Vlaj and Mi{\v s}a Korva and Tatjana Av{\v s}i{\v c}-{\v Z}upanc and Mario Poljak and Teemu Smura and Olli Vapalahti",

year = "2023",

month = mar,

doi = "10.3201/eid2903.221388",

language = "English",

volume = "29",

pages = "649--652",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "3",

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Vauhkonen, H, Kallio-Kokko, H, Hiltunen-Back, E, Lönnqvist, L, Leppäaho-Lakka, J, Mannonen, L , Kant, R , Sironen, T , Kurkela, S , Lappalainen, M, Zorec, TM, Zakotnik, S, Vlaj, D, Korva, M, Avšič-Županc, T, Poljak, M, Smura, T & Vapalahti, O 2023, 'Intrahost Monkeypox Virus Genome Variation in Patient with Early Infection, Finland, 2022', Emerging Infectious Diseases, vol. 29, no. 3, pp. 649-652. https://doi.org/10.3201/eid2903.221388

TY - JOUR

T1 - Intrahost Monkeypox Virus Genome Variation in Patient with Early Infection, Finland, 2022

AU - Vauhkonen, Hanna

AU - Kallio-Kokko, Hannimari

AU - Hiltunen-Back, Eija

AU - Lönnqvist, Lasse

AU - Leppäaho-Lakka, Jaana

AU - Mannonen, Laura

AU - Kant, Ravi

AU - Sironen, Tarja

AU - Kurkela, Satu

AU - Lappalainen, Maija

AU - Zorec, Tomaž Mark

AU - Zakotnik, Samo

AU - Vlaj, Doroteja

AU - Korva, Miša

AU - Avšič-Županc, Tatjana

AU - Poljak, Mario

AU - Smura, Teemu

AU - Vapalahti, Olli

PY - 2023/3

Y1 - 2023/3

N2 - Monkeypox virus was imported into Finland during late May–early June 2022. Intrahost viral genome variation in a sample from 1 patient comprised a major variant with 3 lineage B.1.3–specific mutations and a minor variant with ancestral B.1 nucleotides. Results suggest either ongoing APOBEC3 enzyme–mediated evolution or co-infection.

AB - Monkeypox virus was imported into Finland during late May–early June 2022. Intrahost viral genome variation in a sample from 1 patient comprised a major variant with 3 lineage B.1.3–specific mutations and a minor variant with ancestral B.1 nucleotides. Results suggest either ongoing APOBEC3 enzyme–mediated evolution or co-infection.

KW - 11832 Microbiology and virology

KW - 3141 Health care science

U2 - 10.3201/eid2903.221388

DO - 10.3201/eid2903.221388

M3 - Letter

SN - 1080-6040

VL - 29

SP - 649

EP - 652

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 3

ER -