Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

Guanghui Zong; Zhijian Hu; Sarah O'Keefe; Dale Tranter; Michael J. Iannotti; Ludivine Baron; Belinda Hall; Katherine Corfield; Anja O. Paatero; Mark J. Henderson; Peristera Roboti; Jianhong Zhou; Xianwei Sun; Mugunthan Govindarajan; Jason M. Rohde; Nicolas Blanchard; Rachel Simmonds; James Inglese; Yuchun Du; Caroline Demangel; Stephen High; Ville O. Paavilainen; Wei Q. Shi

doi:10.1021/jacs.8b13506

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

Guanghui Zong, Zhijian Hu, Sarah O'Keefe, Dale Tranter, Michael J. Iannotti, Ludivine Baron, Belinda Hall, Katherine Corfield, Anja O. Paatero, Mark J. Henderson, Peristera Roboti, Jianhong Zhou, Xianwei Sun, Mugunthan Govindarajan, Jason M. Rohde, Nicolas Blanchard, Rachel Simmonds, James Inglese, Yuchun Du, Caroline DemangelStephen High, Ville O. Paavilainen, Wei Q. Shi

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Journal of the American Chemical Society
Volume	141
Issue number	21
Pages (from-to)	8450-8461
Number of pages	12
ISSN	0002-7863
DOIs	https://doi.org/10.1021/jacs.8b13506 https://doi.org/10.1021/jacs.8b13506
Publication status	Published - 29 May 2019
MoE publication type	A1 Journal article-refereed

Bibliographical note

Funding Information:
We thank the Arkansas Nano & Bio Materials Characterization Facility at the Institute for Nano Sciences & Engineering for our imaging studies, and Prof Yoshito Kishi (Harvard University) for the kind gift of synthetic mycolactone A/B used by S.H. and R.S. W.S. is supported by Grant No. R15GM116032 from the National Institute of General Medical Sciences of the National Institutes of Health (NIH) and startup funds from the University of Arkansas. This work was also supported in part by Grant No. P30 GM103450 from the National Institute of General Medical Sciences of the NIH and by seed money from the Arkansas Biosciences Institute (ABI). S.O’K. is the recipient of a Biotechnology and Biological Sciences Research Council (BBSRC) Doctoral Training Programme Award (BB/J014478/ 1), and S.H. holds a Welcome Trust Investigator Award in Science (204957/Z/16/Z). The alpha-1 antitrypsin work was supported by the Alpha-1 Foundation (J.I. and M.J.I.). J.I. and M.J.H. were supported by the intramural program of NCATS, National Institutes of Health, projects 1ZIATR000048-03 (J.I.) and ZIATR000063-04 (M.J.H.). R.S. holds a Welcome Trust Investigator Award in Science (202843/Z/16/Z). C.D. received funding from the Institut Pasteur, the Institut National de la Santé et de la Recherche Med́ icale, and the Fondation Raoul Follereau. N.B.’s synthesis and chemical biology studies of mycolactone were supported by CNRS, Université de Strasbourg, Fondations Potier et Follereau, and the Investisse-ment d’Avenir (Idex Unistra). V.O.P. is supported by the Academy of Finland (Grants 289737 and 314672) and the Sigrid Juselius Foundation.

Funding Information:
We thank the Arkansas Nano & Bio Materials Characterization Facility at the Institute for Nano Sciences & Engineering for our imaging studies, and Prof Yoshito Kishi (Harvard University) for the kind gift of synthetic mycolactone A/B used by S.H. and R.S. W.S. is supported by Grant No. R15GM116032 from the National Institute of General Medical Sciences of the National Institutes of Health (NIH) and startup funds from the University of Arkansas. This work was also supported in part by Grant No. P30 GM103450 from the National Institute of General Medical Sciences of the NIH and by seed money from the Arkansas Biosciences Institute (ABI). S.O'K. is the recipient of a Biotechnology and Biological Sciences Research Council (BBSRC) Doctoral Training Programme Award (BB/J014478/1), and S.H. holds a Welcome Trust Investigator Award in Science (204957/Z/16/Z). The alpha-1 antitrypsin work was supported by the Alpha-1 Foundation (J.I. and M.J.I.). J.I. and M.J.H. were supported by the intramural program of NCATS, National Institutes of Health, projects 1ZIATR000048-03 (J.I.) and ZIATR000063-04 (M.J.H.). R.S. holds a Welcome Trust Investigator Award in Science (202843/Z/16/Z). C.D. received funding from the Institut Pasteur, the Institut National de la Sante et de la Recherche Medicale, and the Fondation Raoul Follereau. N.B.'s synthesis and chemical biology studies of mycolactone were supported by CNRS, Universite de Strasbourg, Fondations Potier et Follereau and the Investissement d'Avenir (Idex Unistra). V.O.P. is supported by the Academy of Finland (Grants 289737 and 314672) and the Sigrid Juselius Foundation.

Publisher Copyright:
© 2019 American Chemical Society.

Fields of Science

NATURAL-PRODUCTS
BIOLOGICAL EVALUATION
RESIN GLYCOSIDES
MYCOLACTONE
INSIGHTS
APRATOXIN
BLOCKADE
SQUAMOSA
REVEALS
ANALOGS
1182 Biochemistry, cell and molecular biology

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10.1021/jacs.8b13506

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Zong, G., Hu, Z., O'Keefe, S., Tranter, D., Iannotti, M. J., Baron, L., Hall, B., Corfield, K., Paatero, A. O., Henderson, M. J., Roboti, P., Zhou, J., Sun, X., Govindarajan, M., Rohde, J. M., Blanchard, N., Simmonds, R., Inglese, J., Du, Y., ... Shi, W. Q. (2019). Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation. Journal of the American Chemical Society, 141(21), 8450-8461. https://doi.org/10.1021/jacs.8b13506, https://doi.org/10.1021/jacs.8b13506

@article{9246207f7fe84116bbbe7ca5656ba6af,

title = "Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation",

keywords = "NATURAL-PRODUCTS, BIOLOGICAL EVALUATION, RESIN GLYCOSIDES, MYCOLACTONE, INSIGHTS, APRATOXIN, BLOCKADE, SQUAMOSA, REVEALS, ANALOGS, 1182 Biochemistry, cell and molecular biology",

author = "Guanghui Zong and Zhijian Hu and Sarah O'Keefe and Dale Tranter and Iannotti, {Michael J.} and Ludivine Baron and Belinda Hall and Katherine Corfield and Paatero, {Anja O.} and Henderson, {Mark J.} and Peristera Roboti and Jianhong Zhou and Xianwei Sun and Mugunthan Govindarajan and Rohde, {Jason M.} and Nicolas Blanchard and Rachel Simmonds and James Inglese and Yuchun Du and Caroline Demangel and Stephen High and Paavilainen, {Ville O.} and Shi, {Wei Q.}",

note = "Funding Information: We thank the Arkansas Nano & Bio Materials Characterization Facility at the Institute for Nano Sciences & Engineering for our imaging studies, and Prof Yoshito Kishi (Harvard University) for the kind gift of synthetic mycolactone A/B used by S.H. and R.S. W.S. is supported by Grant No. R15GM116032 from the National Institute of General Medical Sciences of the National Institutes of Health (NIH) and startup funds from the University of Arkansas. This work was also supported in part by Grant No. P30 GM103450 from the National Institute of General Medical Sciences of the NIH and by seed money from the Arkansas Biosciences Institute (ABI). S.O{\textquoteright}K. is the recipient of a Biotechnology and Biological Sciences Research Council (BBSRC) Doctoral Training Programme Award (BB/J014478/ 1), and S.H. holds a Welcome Trust Investigator Award in Science (204957/Z/16/Z). The alpha-1 antitrypsin work was supported by the Alpha-1 Foundation (J.I. and M.J.I.). J.I. and M.J.H. were supported by the intramural program of NCATS, National Institutes of Health, projects 1ZIATR000048-03 (J.I.) and ZIATR000063-04 (M.J.H.). R.S. holds a Welcome Trust Investigator Award in Science (202843/Z/16/Z). C.D. received funding from the Institut Pasteur, the Institut National de la Sant{\'e} et de la Recherche Me{\'d} icale, and the Fondation Raoul Follereau. N.B.{\textquoteright}s synthesis and chemical biology studies of mycolactone were supported by CNRS, Universit{\'e} de Strasbourg, Fondations Potier et Follereau, and the Investisse-ment d{\textquoteright}Avenir (Idex Unistra). V.O.P. is supported by the Academy of Finland (Grants 289737 and 314672) and the Sigrid Juselius Foundation. Funding Information: We thank the Arkansas Nano & Bio Materials Characterization Facility at the Institute for Nano Sciences & Engineering for our imaging studies, and Prof Yoshito Kishi (Harvard University) for the kind gift of synthetic mycolactone A/B used by S.H. and R.S. W.S. is supported by Grant No. R15GM116032 from the National Institute of General Medical Sciences of the National Institutes of Health (NIH) and startup funds from the University of Arkansas. This work was also supported in part by Grant No. P30 GM103450 from the National Institute of General Medical Sciences of the NIH and by seed money from the Arkansas Biosciences Institute (ABI). S.O'K. is the recipient of a Biotechnology and Biological Sciences Research Council (BBSRC) Doctoral Training Programme Award (BB/J014478/1), and S.H. holds a Welcome Trust Investigator Award in Science (204957/Z/16/Z). The alpha-1 antitrypsin work was supported by the Alpha-1 Foundation (J.I. and M.J.I.). J.I. and M.J.H. were supported by the intramural program of NCATS, National Institutes of Health, projects 1ZIATR000048-03 (J.I.) and ZIATR000063-04 (M.J.H.). R.S. holds a Welcome Trust Investigator Award in Science (202843/Z/16/Z). C.D. received funding from the Institut Pasteur, the Institut National de la Sante et de la Recherche Medicale, and the Fondation Raoul Follereau. N.B.'s synthesis and chemical biology studies of mycolactone were supported by CNRS, Universite de Strasbourg, Fondations Potier et Follereau and the Investissement d'Avenir (Idex Unistra). V.O.P. is supported by the Academy of Finland (Grants 289737 and 314672) and the Sigrid Juselius Foundation. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = may,

day = "29",

doi = "10.1021/jacs.8b13506",

language = "English",

volume = "141",

pages = "8450--8461",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "21",

}

Zong, G, Hu, Z, O'Keefe, S , Tranter, D, Iannotti, MJ, Baron, L, Hall, B, Corfield, K, Paatero, AO, Henderson, MJ, Roboti, P, Zhou, J, Sun, X, Govindarajan, M, Rohde, JM, Blanchard, N, Simmonds, R, Inglese, J, Du, Y, Demangel, C, High, S, Paavilainen, VO & Shi, WQ 2019, 'Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation', Journal of the American Chemical Society, vol. 141, no. 21, pp. 8450-8461. https://doi.org/10.1021/jacs.8b13506, https://doi.org/10.1021/jacs.8b13506

TY - JOUR

T1 - Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

AU - Zong, Guanghui

AU - Hu, Zhijian

AU - O'Keefe, Sarah

AU - Tranter, Dale

AU - Iannotti, Michael J.

AU - Baron, Ludivine

AU - Hall, Belinda

AU - Corfield, Katherine

AU - Paatero, Anja O.

AU - Henderson, Mark J.

AU - Roboti, Peristera

AU - Zhou, Jianhong

AU - Sun, Xianwei

AU - Govindarajan, Mugunthan

AU - Rohde, Jason M.

AU - Blanchard, Nicolas

AU - Simmonds, Rachel

AU - Inglese, James

AU - Du, Yuchun

AU - Demangel, Caroline

AU - High, Stephen

AU - Paavilainen, Ville O.

AU - Shi, Wei Q.

N1 - Funding Information: We thank the Arkansas Nano & Bio Materials Characterization Facility at the Institute for Nano Sciences & Engineering for our imaging studies, and Prof Yoshito Kishi (Harvard University) for the kind gift of synthetic mycolactone A/B used by S.H. and R.S. W.S. is supported by Grant No. R15GM116032 from the National Institute of General Medical Sciences of the National Institutes of Health (NIH) and startup funds from the University of Arkansas. This work was also supported in part by Grant No. P30 GM103450 from the National Institute of General Medical Sciences of the NIH and by seed money from the Arkansas Biosciences Institute (ABI). S.O’K. is the recipient of a Biotechnology and Biological Sciences Research Council (BBSRC) Doctoral Training Programme Award (BB/J014478/ 1), and S.H. holds a Welcome Trust Investigator Award in Science (204957/Z/16/Z). The alpha-1 antitrypsin work was supported by the Alpha-1 Foundation (J.I. and M.J.I.). J.I. and M.J.H. were supported by the intramural program of NCATS, National Institutes of Health, projects 1ZIATR000048-03 (J.I.) and ZIATR000063-04 (M.J.H.). R.S. holds a Welcome Trust Investigator Award in Science (202843/Z/16/Z). C.D. received funding from the Institut Pasteur, the Institut National de la Santé et de la Recherche Med́ icale, and the Fondation Raoul Follereau. N.B.’s synthesis and chemical biology studies of mycolactone were supported by CNRS, Université de Strasbourg, Fondations Potier et Follereau, and the Investisse-ment d’Avenir (Idex Unistra). V.O.P. is supported by the Academy of Finland (Grants 289737 and 314672) and the Sigrid Juselius Foundation. Funding Information: We thank the Arkansas Nano & Bio Materials Characterization Facility at the Institute for Nano Sciences & Engineering for our imaging studies, and Prof Yoshito Kishi (Harvard University) for the kind gift of synthetic mycolactone A/B used by S.H. and R.S. W.S. is supported by Grant No. R15GM116032 from the National Institute of General Medical Sciences of the National Institutes of Health (NIH) and startup funds from the University of Arkansas. This work was also supported in part by Grant No. P30 GM103450 from the National Institute of General Medical Sciences of the NIH and by seed money from the Arkansas Biosciences Institute (ABI). S.O'K. is the recipient of a Biotechnology and Biological Sciences Research Council (BBSRC) Doctoral Training Programme Award (BB/J014478/1), and S.H. holds a Welcome Trust Investigator Award in Science (204957/Z/16/Z). The alpha-1 antitrypsin work was supported by the Alpha-1 Foundation (J.I. and M.J.I.). J.I. and M.J.H. were supported by the intramural program of NCATS, National Institutes of Health, projects 1ZIATR000048-03 (J.I.) and ZIATR000063-04 (M.J.H.). R.S. holds a Welcome Trust Investigator Award in Science (202843/Z/16/Z). C.D. received funding from the Institut Pasteur, the Institut National de la Sante et de la Recherche Medicale, and the Fondation Raoul Follereau. N.B.'s synthesis and chemical biology studies of mycolactone were supported by CNRS, Universite de Strasbourg, Fondations Potier et Follereau and the Investissement d'Avenir (Idex Unistra). V.O.P. is supported by the Academy of Finland (Grants 289737 and 314672) and the Sigrid Juselius Foundation. Publisher Copyright: © 2019 American Chemical Society.

PY - 2019/5/29

Y1 - 2019/5/29

KW - NATURAL-PRODUCTS

KW - BIOLOGICAL EVALUATION

KW - RESIN GLYCOSIDES

KW - MYCOLACTONE

KW - INSIGHTS

KW - APRATOXIN

KW - BLOCKADE

KW - SQUAMOSA

KW - REVEALS

KW - ANALOGS

KW - 1182 Biochemistry, cell and molecular biology

UR - http://www.scopus.com/inward/record.url?scp=85066120803&partnerID=8YFLogxK

U2 - 10.1021/jacs.8b13506

DO - 10.1021/jacs.8b13506

M3 - Article

C2 - 31059257

SN - 0002-7863

VL - 141

SP - 8450

EP - 8461

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 21

ER -

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

Bibliographical note

Fields of Science

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