IRF2BP2 Mutation Is Associated with Increased STAT1 and STAT5 Activation in Two Family Members with Inflammatory Conditions and Lymphopenia

Maaria Palmroth; Hanna Viskari; Mikko R. J. Seppänen; Salla Keskitalo; Anniina Virtanen; Markku Varjosalo; Olli Silvennoinen; Pia Isomäki

doi:10.3390/ph14080797

IRF2BP2 Mutation Is Associated with Increased STAT1 and STAT5 Activation in Two Family Members with Inflammatory Conditions and Lymphopenia

Maaria Palmroth, Hanna Viskari, Mikko R. J. Seppänen, Salla Keskitalo, Anniina Virtanen, Markku Varjosalo, Olli Silvennoinen, Pia Isomäki

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	797
Journal	Pharmaceuticals
Volume	14
Issue number	8
Number of pages	14
ISSN	1424-8247
DOIs	https://doi.org/10.3390/ph14080797
Publication status	Published - Aug 2021
MoE publication type	A1 Journal article-refereed

Fields of Science

interferon regulatory factor-2 binding protein-2 (IRF2BP2)
JAK-STAT pathway
interferons
inflammation
SELECTIVELY MODULATES APOPTOSIS
ACUTE PROMYELOCYTIC LEUKEMIA
FINGER PROTEINS
IDENTIFICATION
TRANSCRIPTION
FUSION
GENE
PATHWAY
DISEASE
COMPLEX
1182 Biochemistry, cell and molecular biology

Access to Document

10.3390/ph14080797Licence: CC BY

pharmaceuticals-14-00797Final published version, 1.72 MBLicence: CC BY

Cite this

@article{398b187e3a6940bdbe7a653c0a8ec901,

title = "IRF2BP2 Mutation Is Associated with Increased STAT1 and STAT5 Activation in Two Family Members with Inflammatory Conditions and Lymphopenia",

keywords = "interferon regulatory factor-2 binding protein-2 (IRF2BP2), JAK-STAT pathway, interferons, inflammation, SELECTIVELY MODULATES APOPTOSIS, ACUTE PROMYELOCYTIC LEUKEMIA, FINGER PROTEINS, IDENTIFICATION, TRANSCRIPTION, FUSION, GENE, PATHWAY, DISEASE, COMPLEX, 1182 Biochemistry, cell and molecular biology",

author = "Maaria Palmroth and Hanna Viskari and Sepp{\"a}nen, {Mikko R. J.} and Salla Keskitalo and Anniina Virtanen and Markku Varjosalo and Olli Silvennoinen and Pia Isom{\"a}ki",

year = "2021",

month = aug,

doi = "10.3390/ph14080797",

language = "English",

volume = "14",

journal = "Pharmaceuticals",

issn = "1424-8247",

publisher = "MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL",

number = "8",

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T1 - IRF2BP2 Mutation Is Associated with Increased STAT1 and STAT5 Activation in Two Family Members with Inflammatory Conditions and Lymphopenia

AU - Palmroth, Maaria

AU - Viskari, Hanna

AU - Seppänen, Mikko R. J.

AU - Keskitalo, Salla

AU - Virtanen, Anniina

AU - Varjosalo, Markku

AU - Silvennoinen, Olli

AU - Isomäki, Pia

PY - 2021/8

Y1 - 2021/8

KW - interferon regulatory factor-2 binding protein-2 (IRF2BP2)

KW - JAK-STAT pathway

KW - interferons

KW - inflammation

KW - SELECTIVELY MODULATES APOPTOSIS

KW - ACUTE PROMYELOCYTIC LEUKEMIA

KW - FINGER PROTEINS

KW - IDENTIFICATION

KW - TRANSCRIPTION

KW - FUSION

KW - GENE

KW - PATHWAY

KW - DISEASE

KW - COMPLEX

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.3390/ph14080797

DO - 10.3390/ph14080797

M3 - Article

SN - 1424-8247

VL - 14

JO - Pharmaceuticals

JF - Pharmaceuticals

IS - 8

M1 - 797

ER -