Itraconazole Increases Ibrutinib Exposure 10-Fold and Reduces Interindividual Variation-A Potentially Beneficial Drug-Drug Interaction

Tuija Tapaninen, Aleksi M. Olkkola, Aleksi Tornio, Mikko Neuvonen, Erkki Elonen, Pertti J. Neuvonen, Mikko Niemi, Janne T. Backman

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalClinical and translational science
Volume13
Issue number2
Pages (from-to)345-351
Number of pages7
ISSN1752-8054
DOIs
Publication statusPublished - Mar 2020
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 3111 Biomedicine
  • 317 Pharmacy
  • ibrutinib
  • itraconazole
  • CYP3A4
  • drug-drug interaction
  • pharmacokinetic booster
  • PROPHYLAXIS
  • TYROSINE KINASE INHIBITOR

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