JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML

Riikka Karjalainen; Tea Pemovska; Mihaela Popa; Minxia Liu; Komal K. Javarappa; Muntasir M. Majumder; Bhagwan Yadav; David Tamborero; Jing Tang; Dmitrii Bychkov; Mika Kontro; Alun Parsons; Minna Suvela; Mireia Mayoral Safont; Kimmo Porkka; Tero Aittokallio; Olli Kallioniemi; Emmet McCormack; Bjorn T. Gjertsen; Krister Wennerberg; Jonathan Knowles; Caroline A. Heckman

doi:10.1182/blood-2016-02-699363

JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML

Riikka Karjalainen, Tea Pemovska, Mihaela Popa, Minxia Liu, Komal K. Javarappa, Muntasir M. Majumder, Bhagwan Yadav, David Tamborero, Jing Tang, Dmitrii Bychkov, Mika Kontro, Alun Parsons, Minna Suvela, Mireia Mayoral Safont, Kimmo Porkka, Tero Aittokallio, Olli Kallioniemi, Emmet McCormack, Bjorn T. Gjertsen, Krister WennerbergJonathan Knowles, Caroline A. Heckman

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Blood
Volume	130
Issue number	6
Pages (from-to)	789-802
Number of pages	14
ISSN	0006-4971
DOIs	https://doi.org/10.1182/blood-2016-02-699363
Publication status	Published - 10 Aug 2017
MoE publication type	A1 Journal article-refereed

Fields of Science

ACUTE MYELOID-LEUKEMIA
TYROSINE KINASE INHIBITOR
MUTANT FLT3-POSITIVE AML
DRUG-RESISTANCE
UP-REGULATION
STEM-CELLS
FLT3
MICROENVIRONMENT
PATHWAY
PKC412
3122 Cancers
3111 Biomedicine

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10.1182/blood-2016-02-699363

Cite this

Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Safont, M. M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T., ... Heckman, C. A. (2017). JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML. Blood, 130(6), 789-802. https://doi.org/10.1182/blood-2016-02-699363

@article{6592d0e49e9e448f9766fb8fc5b2a3ef,

title = "JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML",

keywords = "ACUTE MYELOID-LEUKEMIA, TYROSINE KINASE INHIBITOR, MUTANT FLT3-POSITIVE AML, DRUG-RESISTANCE, UP-REGULATION, STEM-CELLS, FLT3, MICROENVIRONMENT, PATHWAY, PKC412, 3122 Cancers, 3111 Biomedicine",

author = "Riikka Karjalainen and Tea Pemovska and Mihaela Popa and Minxia Liu and Javarappa, {Komal K.} and Majumder, {Muntasir M.} and Bhagwan Yadav and David Tamborero and Jing Tang and Dmitrii Bychkov and Mika Kontro and Alun Parsons and Minna Suvela and Safont, {Mireia Mayoral} and Kimmo Porkka and Tero Aittokallio and Olli Kallioniemi and Emmet McCormack and Gjertsen, {Bjorn T.} and Krister Wennerberg and Jonathan Knowles and Heckman, {Caroline A.}",

year = "2017",

month = aug,

day = "10",

doi = "10.1182/blood-2016-02-699363",

language = "English",

volume = "130",

pages = "789--802",

journal = "Blood",

issn = "0006-4971",

publisher = "Elsevier B.V.",

number = "6",

}

Karjalainen, R, Pemovska, T, Popa, M, Liu, M, Javarappa, KK, Majumder, MM, Yadav, B, Tamborero, D, Tang, J , Bychkov, D , Kontro, M, Parsons, A, Suvela, M, Safont, MM, Porkka, K , Aittokallio, T , Kallioniemi, O, McCormack, E, Gjertsen, BT, Wennerberg, K, Knowles, J & Heckman, CA 2017, 'JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML', Blood, vol. 130, no. 6, pp. 789-802. https://doi.org/10.1182/blood-2016-02-699363

TY - JOUR

T1 - JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML

AU - Karjalainen, Riikka

AU - Pemovska, Tea

AU - Popa, Mihaela

AU - Liu, Minxia

AU - Javarappa, Komal K.

AU - Majumder, Muntasir M.

AU - Yadav, Bhagwan

AU - Tamborero, David

AU - Tang, Jing

AU - Bychkov, Dmitrii

AU - Kontro, Mika

AU - Parsons, Alun

AU - Suvela, Minna

AU - Safont, Mireia Mayoral

AU - Porkka, Kimmo

AU - Aittokallio, Tero

AU - Kallioniemi, Olli

AU - McCormack, Emmet

AU - Gjertsen, Bjorn T.

AU - Wennerberg, Krister

AU - Knowles, Jonathan

AU - Heckman, Caroline A.

PY - 2017/8/10

Y1 - 2017/8/10

KW - ACUTE MYELOID-LEUKEMIA

KW - TYROSINE KINASE INHIBITOR

KW - MUTANT FLT3-POSITIVE AML

KW - DRUG-RESISTANCE

KW - UP-REGULATION

KW - STEM-CELLS

KW - FLT3

KW - MICROENVIRONMENT

KW - PATHWAY

KW - PKC412

KW - 3122 Cancers

KW - 3111 Biomedicine

U2 - 10.1182/blood-2016-02-699363

DO - 10.1182/blood-2016-02-699363

M3 - Article

SN - 0006-4971

VL - 130

SP - 789

EP - 802

JO - Blood

JF - Blood

IS - 6

ER -