Key molecules in lymphatic development, function, and identification

Research output: Contribution to journalArticleScientificpeer-review

Abstract

While both blood and lymphatic vessels transport fluids and thus share many similarities, they also show functional and structural differences, which can be used to differentiate them. Specific visualization of lymphatic vessels has historically been and still is a pivot point in lymphatic research. Many of the proteins that are investigated by molecular biologists in lymphatic research have been defined as marker molecules, i.e. to visualize and distinguish lymphatic endothelial cells (LECs) from other cell types, most notably from blood vascular endothelial cells (BECs) and cells of the hematopoietic lineage.

Among the factors that drive the developmental differentiation of lymphatic structures from venous endothelium, Prospero homeobox protein 1 (PROX1) is the master transcriptional regulator. PROX1 maintains lymphatic identity also in the adult organism and thus is a universal LEC marker. Vascular endothelial growth factor receptor-3 (VEGFR-3) is the major tyrosine kinase receptor that drives LEC proliferation and migration. The major activator for VEGFR-3 is vascular endothelial growth factor-C (VEGF-C). However, before VEGF-C can signal, it needs to be proteolytically activated by an extracellular protein complex comprised of Collagen and calcium binding EGF domains 1 (CCBE1) protein and the protease A disintegrin and metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3).

This minireview attempts to give an overview of these and a few other central proteins that scientific inquiry has linked specifically to the lymphatic vasculature. It is limited in scope to a brief description of their main functions, properties and developmental roles. (C) 2018 The Author(s). Published by Elsevier GmbH.

Original languageEnglish
JournalAnnals of Anatomy
Volume219
Pages (from-to)25-34
Number of pages10
ISSN0940-9602
DOIs
Publication statusPublished - 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • C VEGF-C
  • CELL-CELL CONTACTS
  • Cell surface receptors
  • DENDRITIC CELLS
  • ENDOTHELIAL-GROWTH-FACTOR
  • Growth factors
  • HYALURONAN RECEPTOR LYVE-1
  • Lymphangiogenesis
  • Lymphatic marker
  • MONOCLONAL-ANTIBODY
  • TUMOR LYMPHANGIOGENESIS
  • TYROSINE KINASES
  • Transcription factors
  • VASCULAR DEVELOPMENT
  • VEGF-C/VEGFR-3 signaling
  • VESSEL DEVELOPMENT
  • Vascular biology
  • 3122 Cancers
  • 3126 Surgery, anesthesiology, intensive care, radiology

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