KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference

Gunter Schumann, Chunyu Liu, Paul O'Reilly, He Gao, Parkyong Song, Bing Xu, Barbara Ruggeri, Najaf Amin, Tianye Jia, Sarah Preis, Marcelo Segura Lepe, Shizuo Akira, Caterina Barbieri, Sebastian Baumeister, Stephane Cauchi, Toni-Kim Clarke, Stefan Enroth, Krista Fischer, Jenni Hallfors, Sarah E. HarrisSaskia Hieber, Edith Hofer, Jouke-Jan Hottenga, Asa Johansson, PeterK. Joshi, Niina Kaartinen, Jaana Laitinen, Rozenn Lemaitre, Anu Loukola, Jian'an Luan, Leo-Pekka Lyytikainen, Massimo Mangino, Ani Manichaikul, Hamdi Mbarek, Yuri Milaneschi, Alireza Moayyeri, Kenneth Mukamal, Christopher Nelson, Jennifer Nettleton, Eemil Partinen, Rajesh Rawal, Antonietta Robino, Lynda Rose, Cinzia Sala, Takashi Satoh, Reinhold Schmidt, Katharina Schrautz, Robert Scott, Albert Vernon Smith, John M. Starr, Alexander Teumer, Stella Trompet, Andre G. Uitterlinden, Cristina Venturini, Anne-Claire Vergnaud, Niek Verweij, Veronique Vitart, Dragana Vuckovic, Juho Wedenoja, Loic Yengo, Bing Yu, Weihua Zhang, Jing Hua Zhao, Dorret I. Boomsma, John Chambers, Daniel I. Chasman, Toniolo Daniela, Eco de Geus, Ian Deary, Johan G. Eriksson, Tonu Esko, Volker Eulenburg, Oscar H. Franco, Philippe Froguel, Christian Gieger, Hans J. Grabe, Vilmundur Gudnason, Ulf Gyllensten, Tamara B. Harris, Anna-Liisa Hartikainen, Andrew C. Heath, Lynne Hocking, Albert Hofman, Cornelia Huth, Marjo-Riitta Jarvelin, J. Wouter Jukema, Jaakko Kaprio, Jaspal S. Kooner, Zoltan Kutalik, Jari Lahti, Claudia Langenberg, Terho Lehtimaki, Yongmei Liu, Pamela A. F. Madden, Nicholas Martin, Alanna Morrison, Brenda Penninx, Nicola Pirastu, Bruce Psaty, Olli Raitakari, Paul Ridker, Richard Rose, Jerome I. Rotter, Nilesh J. Samani, Helena Schmidt, Tim D. Spector, David Stott, David Strachan, Ioanna Tzoulaki, Pim van der Harst, Cornelia M. van Duijn, Pedro Marques-Vidal, Peter Vollenweider, Nicholas J. Wareham, John B. Whitfield, James Wilson, Bruce Wolffenbuttel, Georgy Bakalkin, Evangelos Evangelou, Yun Liu, Kenneth M. Rice, Sylvane Desrivieres, Steven A. Kliewer, David J. Mangelsdorf, Christian P. Muller, Daniel Levy, Paul Elliott

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalProceedings of the National Academy of Sciences of the United States of America
Volume113
Issue number50
Pages (from-to)14372-14377
Number of pages6
ISSN0027-8424
DOIs
Publication statusPublished - 13 Dec 2016
MoE publication typeA1 Journal article-refereed

Fields of Science

  • alcohol consumption
  • human
  • beta-Klotho
  • FGF21
  • mouse model
  • GENOME-WIDE ASSOCIATION
  • CONSUMPTION
  • DISEASE
  • ACTIVATION
  • DEPENDENCE
  • SWEET
  • LIVER
  • HEART
  • MICE
  • 3142 Public health care science, environmental and occupational health
  • 3111 Biomedicine
  • 515 Psychology

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