In this focused review, we address the role of the kallikrein-related peptidase 3 (KLK3), also known as prostate-specific antigen (PSA), in the regulation of angiogenesis. Early studies suggest that KLK3 is able to inhibit angiogenic processes, which is most likely dependent on its proteolytic activity. However, more recent evidence suggests that KLK3 may also have an opposite role, mediated by the ability of KLK3 to activate the (lymph)angiogenic vascular endothelial growth factors VEGF-C and VEGF-D, further discussed in the review.
Original languageEnglish
Article number13545
JournalInternational Journal of Molecular Sciences
Issue number24
Number of pages14
Publication statusPublished - 17 Dec 2021
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 3111 Biomedicine

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