Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report

Toni T. Seppala, Aysel Ahadova, Mev Dominguez-Valentin, Finlay Macrae, D. Gareth Evans, Christina Therkildsen, Julian Sampson, Rodney Scott, John Burn, Gabriela Möslein, Inge Bernstein, Elke Holinski-Feder, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, Charlotte Kvist Lautrup, Annika Lindblom, John-Paul Plazzer, Ingrid Winship, Douglas Tjandra & 37 others Lior H. Katz, Stefan Aretz, Robert Hueneburg, Stefanie Holzapfel, Karl Heinimann, Adriana Della Valle, Florencia Neffa, Nathan Gluck, Wouter H. de Vos Tot Nederveen Cappel, Hans Vasen, Monika Morak, Verena Steinke-Lange, Christoph Engel, Nils Rahner, Wolff Schmiegel, Deepak Vangala, Huw Thomas, Kate Green, Fiona Lalloo, Emma J. Crosbie, James Hill, Gabriel Capella, Marta Pineda, Matilde Navarro, Ignacio Blanco, Sanne ten Broeke, Maartje Nielsen, Ken Ljungmann, Sigve Nakken, Noralane Lindor, Ian Frayling, Eivind Hovig, Lone Sunde, Matthias Kloor, Jukka-Pekka Mecklin, Mette Kalager, Pal Moller

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
Article number8
JournalHereditary Cancer in Clinical Practice
Volume17
Number of pages8
ISSN1731-2302
DOIs
Publication statusPublished - 28 Feb 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Mismatch repair
  • Microsatellite instability
  • Lynch syndrome
  • Hereditary cancer
  • Colorectal cancer
  • Hereditary nonpolyposis colorectal cancer
  • Colonoscopy
  • Endoscopy
  • Surveillance
  • Screening
  • Over-diagnosis
  • COLORECTAL-CANCER
  • COLONOSCOPIC SURVEILLANCE
  • RISK
  • FAMILIES
  • MUTATION
  • ADENOMA
  • 3122 Cancers

Cite this

Seppala, Toni T. ; Ahadova, Aysel ; Dominguez-Valentin, Mev ; Macrae, Finlay ; Evans, D. Gareth ; Therkildsen, Christina ; Sampson, Julian ; Scott, Rodney ; Burn, John ; Möslein, Gabriela ; Bernstein, Inge ; Holinski-Feder, Elke ; Pylvänäinen, Kirsi ; Renkonen-Sinisalo, Laura ; Lepistö, Anna ; Lautrup, Charlotte Kvist ; Lindblom, Annika ; Plazzer, John-Paul ; Winship, Ingrid ; Tjandra, Douglas ; Katz, Lior H. ; Aretz, Stefan ; Hueneburg, Robert ; Holzapfel, Stefanie ; Heinimann, Karl ; Della Valle, Adriana ; Neffa, Florencia ; Gluck, Nathan ; Cappel, Wouter H. de Vos Tot Nederveen ; Vasen, Hans ; Morak, Monika ; Steinke-Lange, Verena ; Engel, Christoph ; Rahner, Nils ; Schmiegel, Wolff ; Vangala, Deepak ; Thomas, Huw ; Green, Kate ; Lalloo, Fiona ; Crosbie, Emma J. ; Hill, James ; Capella, Gabriel ; Pineda, Marta ; Navarro, Matilde ; Blanco, Ignacio ; ten Broeke, Sanne ; Nielsen, Maartje ; Ljungmann, Ken ; Nakken, Sigve ; Lindor, Noralane ; Frayling, Ian ; Hovig, Eivind ; Sunde, Lone ; Kloor, Matthias ; Mecklin, Jukka-Pekka ; Kalager, Mette ; Moller, Pal. / Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report. In: Hereditary Cancer in Clinical Practice. 2019 ; Vol. 17.
@article{590782ccefd54926b79f902905559488,
title = "Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report",
keywords = "Mismatch repair, Microsatellite instability, Lynch syndrome, Hereditary cancer, Colorectal cancer, Hereditary nonpolyposis colorectal cancer, Colonoscopy, Endoscopy, Surveillance, Screening, Over-diagnosis, COLORECTAL-CANCER, COLONOSCOPIC SURVEILLANCE, RISK, FAMILIES, MUTATION, ADENOMA, 3122 Cancers",
author = "Seppala, {Toni T.} and Aysel Ahadova and Mev Dominguez-Valentin and Finlay Macrae and Evans, {D. Gareth} and Christina Therkildsen and Julian Sampson and Rodney Scott and John Burn and Gabriela M{\"o}slein and Inge Bernstein and Elke Holinski-Feder and Kirsi Pylv{\"a}n{\"a}inen and Laura Renkonen-Sinisalo and Anna Lepist{\"o} and Lautrup, {Charlotte Kvist} and Annika Lindblom and John-Paul Plazzer and Ingrid Winship and Douglas Tjandra and Katz, {Lior H.} and Stefan Aretz and Robert Hueneburg and Stefanie Holzapfel and Karl Heinimann and {Della Valle}, Adriana and Florencia Neffa and Nathan Gluck and Cappel, {Wouter H. de Vos Tot Nederveen} and Hans Vasen and Monika Morak and Verena Steinke-Lange and Christoph Engel and Nils Rahner and Wolff Schmiegel and Deepak Vangala and Huw Thomas and Kate Green and Fiona Lalloo and Crosbie, {Emma J.} and James Hill and Gabriel Capella and Marta Pineda and Matilde Navarro and Ignacio Blanco and {ten Broeke}, Sanne and Maartje Nielsen and Ken Ljungmann and Sigve Nakken and Noralane Lindor and Ian Frayling and Eivind Hovig and Lone Sunde and Matthias Kloor and Jukka-Pekka Mecklin and Mette Kalager and Pal Moller",
year = "2019",
month = "2",
day = "28",
doi = "10.1186/s13053-019-0106-8",
language = "English",
volume = "17",
journal = "Hereditary Cancer in Clinical Practice",
issn = "1731-2302",
publisher = "BMC",

}

Seppala, TT, Ahadova, A, Dominguez-Valentin, M, Macrae, F, Evans, DG, Therkildsen, C, Sampson, J, Scott, R, Burn, J, Möslein, G, Bernstein, I, Holinski-Feder, E, Pylvänäinen, K, Renkonen-Sinisalo, L, Lepistö, A, Lautrup, CK, Lindblom, A, Plazzer, J-P, Winship, I, Tjandra, D, Katz, LH, Aretz, S, Hueneburg, R, Holzapfel, S, Heinimann, K, Della Valle, A, Neffa, F, Gluck, N, Cappel, WHDVTN, Vasen, H, Morak, M, Steinke-Lange, V, Engel, C, Rahner, N, Schmiegel, W, Vangala, D, Thomas, H, Green, K, Lalloo, F, Crosbie, EJ, Hill, J, Capella, G, Pineda, M, Navarro, M, Blanco, I, ten Broeke, S, Nielsen, M, Ljungmann, K, Nakken, S, Lindor, N, Frayling, I, Hovig, E, Sunde, L, Kloor, M, Mecklin, J-P, Kalager, M & Moller, P 2019, 'Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report', Hereditary Cancer in Clinical Practice, vol. 17, 8. https://doi.org/10.1186/s13053-019-0106-8

Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report. / Seppala, Toni T.; Ahadova, Aysel; Dominguez-Valentin, Mev; Macrae, Finlay; Evans, D. Gareth; Therkildsen, Christina; Sampson, Julian; Scott, Rodney; Burn, John; Möslein, Gabriela; Bernstein, Inge; Holinski-Feder, Elke; Pylvänäinen, Kirsi; Renkonen-Sinisalo, Laura; Lepistö, Anna; Lautrup, Charlotte Kvist; Lindblom, Annika; Plazzer, John-Paul; Winship, Ingrid; Tjandra, Douglas; Katz, Lior H.; Aretz, Stefan; Hueneburg, Robert; Holzapfel, Stefanie; Heinimann, Karl; Della Valle, Adriana; Neffa, Florencia; Gluck, Nathan; Cappel, Wouter H. de Vos Tot Nederveen; Vasen, Hans; Morak, Monika; Steinke-Lange, Verena; Engel, Christoph; Rahner, Nils; Schmiegel, Wolff; Vangala, Deepak; Thomas, Huw; Green, Kate; Lalloo, Fiona; Crosbie, Emma J.; Hill, James; Capella, Gabriel; Pineda, Marta; Navarro, Matilde; Blanco, Ignacio; ten Broeke, Sanne; Nielsen, Maartje; Ljungmann, Ken; Nakken, Sigve; Lindor, Noralane; Frayling, Ian; Hovig, Eivind; Sunde, Lone; Kloor, Matthias; Mecklin, Jukka-Pekka; Kalager, Mette; Moller, Pal.

In: Hereditary Cancer in Clinical Practice, Vol. 17, 8, 28.02.2019.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report

AU - Seppala, Toni T.

AU - Ahadova, Aysel

AU - Dominguez-Valentin, Mev

AU - Macrae, Finlay

AU - Evans, D. Gareth

AU - Therkildsen, Christina

AU - Sampson, Julian

AU - Scott, Rodney

AU - Burn, John

AU - Möslein, Gabriela

AU - Bernstein, Inge

AU - Holinski-Feder, Elke

AU - Pylvänäinen, Kirsi

AU - Renkonen-Sinisalo, Laura

AU - Lepistö, Anna

AU - Lautrup, Charlotte Kvist

AU - Lindblom, Annika

AU - Plazzer, John-Paul

AU - Winship, Ingrid

AU - Tjandra, Douglas

AU - Katz, Lior H.

AU - Aretz, Stefan

AU - Hueneburg, Robert

AU - Holzapfel, Stefanie

AU - Heinimann, Karl

AU - Della Valle, Adriana

AU - Neffa, Florencia

AU - Gluck, Nathan

AU - Cappel, Wouter H. de Vos Tot Nederveen

AU - Vasen, Hans

AU - Morak, Monika

AU - Steinke-Lange, Verena

AU - Engel, Christoph

AU - Rahner, Nils

AU - Schmiegel, Wolff

AU - Vangala, Deepak

AU - Thomas, Huw

AU - Green, Kate

AU - Lalloo, Fiona

AU - Crosbie, Emma J.

AU - Hill, James

AU - Capella, Gabriel

AU - Pineda, Marta

AU - Navarro, Matilde

AU - Blanco, Ignacio

AU - ten Broeke, Sanne

AU - Nielsen, Maartje

AU - Ljungmann, Ken

AU - Nakken, Sigve

AU - Lindor, Noralane

AU - Frayling, Ian

AU - Hovig, Eivind

AU - Sunde, Lone

AU - Kloor, Matthias

AU - Mecklin, Jukka-Pekka

AU - Kalager, Mette

AU - Moller, Pal

PY - 2019/2/28

Y1 - 2019/2/28

KW - Mismatch repair

KW - Microsatellite instability

KW - Lynch syndrome

KW - Hereditary cancer

KW - Colorectal cancer

KW - Hereditary nonpolyposis colorectal cancer

KW - Colonoscopy

KW - Endoscopy

KW - Surveillance

KW - Screening

KW - Over-diagnosis

KW - COLORECTAL-CANCER

KW - COLONOSCOPIC SURVEILLANCE

KW - RISK

KW - FAMILIES

KW - MUTATION

KW - ADENOMA

KW - 3122 Cancers

U2 - 10.1186/s13053-019-0106-8

DO - 10.1186/s13053-019-0106-8

M3 - Article

VL - 17

JO - Hereditary Cancer in Clinical Practice

JF - Hereditary Cancer in Clinical Practice

SN - 1731-2302

M1 - 8

ER -