LACTB is a filament-forming protein localized in mitochondria

Zydrune Polianskyte-Prause, Nina Peitsaro, Arvydas Dapkunas, Julius Liobikas, Rabah Soliymani, Maciej Lalowski, Oliver Speer, Jani Seitsonen, Sarah Jane Butcher, Grazia M Cereghetti, Matts D Linder, Michael Merckel, James Thompson, Ove Eriksson-Rosenberg

Research output: Contribution to journalArticleScientificpeer-review


LACTB is a mammalian active-site serine protein that has evolved from a bacterial penicillin-binding protein. Penicillin-binding proteins are involved in the metabolism of peptidoglycan, the major bacterial cell wall constituent, implying that LACTB has been endowed with novel biochemical properties during eukaryote evolution. Here we demonstrate that LACTB is localized in the mitochondrial intermembrane space, where it is polymerized into stable filaments with a length extending more than a hundred nanometers. We infer that LACTB, through polymerization, promotes intramitochondrial membrane organization and micro-compartmentalization. These findings have implications for our understanding of mitochondrial evolution and function.
Original languageEnglish
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number45
Pages (from-to)18960-18965
Number of pages6
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 118 Biological sciences

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