Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Andrew P. Morris, Benjamin F. Voight, Tanya M. Teslovich, Teresa Ferreira, Ayellet V. Segre, Valgerdur Steinthorsdottir, Rona J. Strawbridge, Hassan Khan, Harald Grallert, Anubha Mahajan, Inga Prokopenko, Hyun Min Kang, Christian Dina, Tonu Esko, Ross M. Fraser, Stavroula Kanoni, Ashish Kumar, Vasiliki Lagou, Claudia Langenberg, Jian'an LuanCecilia M. Lindgren, Martina Mueller-Nurasyid, Sonali Pechlivanis, N. William Rayner, Laura J. Scott, Steven Wiltshire, Loic Yengo, Leena Kinnunen, Elizabeth J. Rossin, Soumya Raychaudhuri, Andrew D. Johnson, Antigone S. Dimas, Ruth J. F. Loos, Sailaja Vedantam, Han Chen, Jose C. Florez, Caroline Fox, Ching-Ti Liu, Denis Rybin, David J. Couper, Wen Hong L. Kao, Man Li, Emmi Tikkanen, Tom Forsen, Johan G. Eriksson, Leena Palotie, Tiinamaija Tuomi, Bo Isomaa, Jaakko Tuomilehto, Samuli Ripatti, Wellcome Trust Case Control, Meta-Anal Glucose Insulin-Related, Genetic Invest ANthropometric, Asian Genetic Epidemiology, S Asian Type 2 Diabet SAT2D, DIAbet Genetics Replication

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalNature Genetics
Volume44
Issue number9
Pages (from-to)981-990
Number of pages10
ISSN1061-4036
DOIs
Publication statusPublished - 1 Sep 2012
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 3111 Biomedicine
  • 3121 Internal medicine

Cite this

Morris, A. P., Voight, B. F., Teslovich, T. M., Ferreira, T., Segre, A. V., Steinthorsdottir, V., ... Wellcome Trust Case Control, Meta-Anal Glucose Insulin-Related, Genetic Invest ANthropometric, Asian Genetic Epidemiology, S Asian Type 2 Diabet SAT2D, DIAbet Genetics Replication (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44(9), 981-990. https://doi.org/10.1038/ng.2383
Morris, Andrew P. ; Voight, Benjamin F. ; Teslovich, Tanya M. ; Ferreira, Teresa ; Segre, Ayellet V. ; Steinthorsdottir, Valgerdur ; Strawbridge, Rona J. ; Khan, Hassan ; Grallert, Harald ; Mahajan, Anubha ; Prokopenko, Inga ; Kang, Hyun Min ; Dina, Christian ; Esko, Tonu ; Fraser, Ross M. ; Kanoni, Stavroula ; Kumar, Ashish ; Lagou, Vasiliki ; Langenberg, Claudia ; Luan, Jian'an ; Lindgren, Cecilia M. ; Mueller-Nurasyid, Martina ; Pechlivanis, Sonali ; Rayner, N. William ; Scott, Laura J. ; Wiltshire, Steven ; Yengo, Loic ; Kinnunen, Leena ; Rossin, Elizabeth J. ; Raychaudhuri, Soumya ; Johnson, Andrew D. ; Dimas, Antigone S. ; Loos, Ruth J. F. ; Vedantam, Sailaja ; Chen, Han ; Florez, Jose C. ; Fox, Caroline ; Liu, Ching-Ti ; Rybin, Denis ; Couper, David J. ; Kao, Wen Hong L. ; Li, Man ; Tikkanen, Emmi ; Forsen, Tom ; Eriksson, Johan G. ; Palotie, Leena ; Tuomi, Tiinamaija ; Isomaa, Bo ; Tuomilehto, Jaakko ; Ripatti, Samuli ; Wellcome Trust Case Control, Meta-Anal Glucose Insulin-Related, Genetic Invest ANthropometric, Asian Genetic Epidemiology, S Asian Type 2 Diabet SAT2D, DIAbet Genetics Replication. / Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. In: Nature Genetics. 2012 ; Vol. 44, No. 9. pp. 981-990.
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title = "Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes",
keywords = "3111 Biomedicine, 3121 Internal medicine",
author = "Morris, {Andrew P.} and Voight, {Benjamin F.} and Teslovich, {Tanya M.} and Teresa Ferreira and Segre, {Ayellet V.} and Valgerdur Steinthorsdottir and Strawbridge, {Rona J.} and Hassan Khan and Harald Grallert and Anubha Mahajan and Inga Prokopenko and Kang, {Hyun Min} and Christian Dina and Tonu Esko and Fraser, {Ross M.} and Stavroula Kanoni and Ashish Kumar and Vasiliki Lagou and Claudia Langenberg and Jian'an Luan and Lindgren, {Cecilia M.} and Martina Mueller-Nurasyid and Sonali Pechlivanis and Rayner, {N. William} and Scott, {Laura J.} and Steven Wiltshire and Loic Yengo and Leena Kinnunen and Rossin, {Elizabeth J.} and Soumya Raychaudhuri and Johnson, {Andrew D.} and Dimas, {Antigone S.} and Loos, {Ruth J. F.} and Sailaja Vedantam and Han Chen and Florez, {Jose C.} and Caroline Fox and Ching-Ti Liu and Denis Rybin and Couper, {David J.} and Kao, {Wen Hong L.} and Man Li and Emmi Tikkanen and Tom Forsen and Eriksson, {Johan G.} and Leena Palotie and Tiinamaija Tuomi and Bo Isomaa and Jaakko Tuomilehto and Samuli Ripatti and {Wellcome Trust Case Control, Meta-Anal Glucose Insulin-Related, Genetic Invest ANthropometric, Asian Genetic Epidemiology, S Asian Type 2 Diabet SAT2D, DIAbet Genetics Replication}",
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Morris, AP, Voight, BF, Teslovich, TM, Ferreira, T, Segre, AV, Steinthorsdottir, V, Strawbridge, RJ, Khan, H, Grallert, H, Mahajan, A, Prokopenko, I, Kang, HM, Dina, C, Esko, T, Fraser, RM, Kanoni, S, Kumar, A, Lagou, V, Langenberg, C, Luan, J, Lindgren, CM, Mueller-Nurasyid, M, Pechlivanis, S, Rayner, NW, Scott, LJ, Wiltshire, S, Yengo, L, Kinnunen, L, Rossin, EJ, Raychaudhuri, S, Johnson, AD, Dimas, AS, Loos, RJF, Vedantam, S, Chen, H, Florez, JC, Fox, C, Liu, C-T, Rybin, D, Couper, DJ, Kao, WHL, Li, M, Tikkanen, E, Forsen, T, Eriksson, JG, Palotie, L, Tuomi, T, Isomaa, B, Tuomilehto, J, Ripatti, S & Wellcome Trust Case Control, Meta-Anal Glucose Insulin-Related, Genetic Invest ANthropometric, Asian Genetic Epidemiology, S Asian Type 2 Diabet SAT2D, DIAbet Genetics Replication 2012, 'Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes', Nature Genetics, vol. 44, no. 9, pp. 981-990. https://doi.org/10.1038/ng.2383

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. / Morris, Andrew P.; Voight, Benjamin F.; Teslovich, Tanya M.; Ferreira, Teresa; Segre, Ayellet V.; Steinthorsdottir, Valgerdur; Strawbridge, Rona J.; Khan, Hassan; Grallert, Harald; Mahajan, Anubha; Prokopenko, Inga; Kang, Hyun Min; Dina, Christian; Esko, Tonu; Fraser, Ross M.; Kanoni, Stavroula; Kumar, Ashish; Lagou, Vasiliki; Langenberg, Claudia; Luan, Jian'an; Lindgren, Cecilia M.; Mueller-Nurasyid, Martina; Pechlivanis, Sonali; Rayner, N. William; Scott, Laura J.; Wiltshire, Steven; Yengo, Loic; Kinnunen, Leena; Rossin, Elizabeth J.; Raychaudhuri, Soumya; Johnson, Andrew D.; Dimas, Antigone S.; Loos, Ruth J. F.; Vedantam, Sailaja; Chen, Han; Florez, Jose C.; Fox, Caroline; Liu, Ching-Ti; Rybin, Denis; Couper, David J.; Kao, Wen Hong L.; Li, Man; Tikkanen, Emmi; Forsen, Tom; Eriksson, Johan G.; Palotie, Leena; Tuomi, Tiinamaija; Isomaa, Bo; Tuomilehto, Jaakko; Ripatti, Samuli; Wellcome Trust Case Control, Meta-Anal Glucose Insulin-Related, Genetic Invest ANthropometric, Asian Genetic Epidemiology, S Asian Type 2 Diabet SAT2D, DIAbet Genetics Replication.

In: Nature Genetics, Vol. 44, No. 9, 01.09.2012, p. 981-990.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

AU - Morris, Andrew P.

AU - Voight, Benjamin F.

AU - Teslovich, Tanya M.

AU - Ferreira, Teresa

AU - Segre, Ayellet V.

AU - Steinthorsdottir, Valgerdur

AU - Strawbridge, Rona J.

AU - Khan, Hassan

AU - Grallert, Harald

AU - Mahajan, Anubha

AU - Prokopenko, Inga

AU - Kang, Hyun Min

AU - Dina, Christian

AU - Esko, Tonu

AU - Fraser, Ross M.

AU - Kanoni, Stavroula

AU - Kumar, Ashish

AU - Lagou, Vasiliki

AU - Langenberg, Claudia

AU - Luan, Jian'an

AU - Lindgren, Cecilia M.

AU - Mueller-Nurasyid, Martina

AU - Pechlivanis, Sonali

AU - Rayner, N. William

AU - Scott, Laura J.

AU - Wiltshire, Steven

AU - Yengo, Loic

AU - Kinnunen, Leena

AU - Rossin, Elizabeth J.

AU - Raychaudhuri, Soumya

AU - Johnson, Andrew D.

AU - Dimas, Antigone S.

AU - Loos, Ruth J. F.

AU - Vedantam, Sailaja

AU - Chen, Han

AU - Florez, Jose C.

AU - Fox, Caroline

AU - Liu, Ching-Ti

AU - Rybin, Denis

AU - Couper, David J.

AU - Kao, Wen Hong L.

AU - Li, Man

AU - Tikkanen, Emmi

AU - Forsen, Tom

AU - Eriksson, Johan G.

AU - Palotie, Leena

AU - Tuomi, Tiinamaija

AU - Isomaa, Bo

AU - Tuomilehto, Jaakko

AU - Ripatti, Samuli

AU - Wellcome Trust Case Control, Meta-Anal Glucose Insulin-Related, Genetic Invest ANthropometric, Asian Genetic Epidemiology, S Asian Type 2 Diabet SAT2D, DIAbet Genetics Replication

N1 - WOS:000308491200009 Volume: Proceeding volume:

PY - 2012/9/1

Y1 - 2012/9/1

KW - 3111 Biomedicine

KW - 3121 Internal medicine

U2 - 10.1038/ng.2383

DO - 10.1038/ng.2383

M3 - Article

VL - 44

SP - 981

EP - 990

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

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Morris AP, Voight BF, Teslovich TM, Ferreira T, Segre AV, Steinthorsdottir V et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics. 2012 Sep 1;44(9):981-990. https://doi.org/10.1038/ng.2383