Left Ventricular speckle tracking echocardiography changes among early-stage breast cancer patients three years after radiotherapy

S.S. Tuohinen, T. Skytta, H. Huhtala, V. Virtanen, P.-L. Kellokumpu-Lehtinen, P. Raatikainen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background/Aim: Chest radiotherapy (RT) doubles late cardiac mortality. This study aimed to evaluate the evolution of cardiac changes in speckle tracking echocardiography during a three-year follow-up. Materials and Methods: This prospective study included 81 chemotherapy-naïve early-stage breast cancer patients who were evaluated at baseline, immediately after RT and three years after RT. Sixty-one patients had left-sided (LSBC) and 20 right-sided breast cancer (RSBC). Results: Global longitudinal strain (GLS) declined from baseline –18.0±3.3% to –17.0±3.0% (p=0.015) at the three-year follow-up examination. A decline over 15% (GLS15) was observed in 19 (27%) patients. GLS15 was independently associated with aromatase inhibitor use (β=–1.977, p=0.001). In regional analysis, patients with LSBC had apical strain decline by 3.2±5.5% (p
Original languageEnglish
JournalAnticancer Research
Volume39
Issue number8
Pages (from-to)4227-4236
Number of pages10
ISSN0250-7005
DOIs
Publication statusPublished - 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Breast cancer
  • Midterm follow-up
  • Radiotherapy
  • Speckle tracking echocardiography
  • angiotensin receptor antagonist
  • aromatase inhibitor
  • beta adrenergic receptor blocking agent
  • calcium channel blocking agent
  • dipeptidyl carboxypeptidase inhibitor
  • hydroxymethylglutaryl coenzyme A reductase inhibitor
  • tamoxifen
  • adult
  • aged
  • apical strain
  • Article
  • breast cancer
  • breast radiotherapy
  • cancer hormone therapy
  • cancer patient
  • cancer radiotherapy
  • cardiovascular parameters
  • circumferential strain
  • dyslipidemia
  • early cancer
  • female
  • follow up
  • global longitudinal strain
  • heart left ventricle
  • heart left ventricle ejection fraction
  • heart left ventricle enddiastolic diameter
  • heart left ventricle endsystolic diameter
  • human
  • hypertension
  • left ventricular apex
  • major clinical study
  • priority journal
  • prospective study
  • radiation dose
  • speckle tracking echocardiography
  • tricuspid annular plane systolic excursion
  • breast tumor
  • complication
  • echocardiography
  • heart
  • heart left ventricle function
  • heart ventricle
  • middle aged
  • pathology
  • pathophysiology
  • radiation response
  • Aged
  • Breast Neoplasms
  • Echocardiography
  • Female
  • Heart
  • Heart Ventricles
  • Humans
  • Middle Aged
  • Ventricular Dysfunction, Left
  • 3122 Cancers

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