Locus for severity implicates CNS resilience in progression of multiple sclerosis

International Multiple Sclerosis Genetics Consortium; MultipleMS Consortium; Adil Harroud; Pernilla J. Stridh; Jacob H. McCauley; Janna Saarela; Aletta M. R. van den Bosch; Hendrik Engelenburg; Ashley Beecham; Lars Alfredsson; Katayoun Alikhani; Lilyana Amezcua; Till F. M. Andlauer; Maria Ban; Lisa Barcellos; Nadia Barizzone; Tone Berge; Achim Berthele; Stefan Bittner; Steffan Bos; Farren B. S. Briggs; Stacy Caillier; Peter Calabresi; Domenico Caputo; David Carmona-Burgos; Paola Cavalla; Elisabeth Celius; Gabriel Cerono; Angel Chinea; Tanuja Chitnis; Ferdinando Clarelli; Manuel Comabella; Giancarlo Comi; Chris Cotsapas; Bruce C. A. Cree; Sandra D'Alfonso; Efthimios Dardiotis; Philip De Jager; Silvia Delgado; Benedicte Dubois; Sinah Engel; Federica Esposito; Marzena Fabis-Pedrini; Massimo Filippi; Kathryn Fitzgerald; Christiane Gasperi; Lissette Gomez; Refujia Gomez; Georgios Hadjigeorgiou; Joerg Hamann; Friederike Held; Kimmo Paakkonen

doi:10.1038/s41586-023-06250-x

Locus for severity implicates CNS resilience in progression of multiple sclerosis

International Multiple Sclerosis Genetics Consortium, MultipleMS Consortium, Adil Harroud, Pernilla J. Stridh, Jacob H. McCauley, Janna Saarela, Aletta M. R. van den Bosch, Hendrik Engelenburg, Ashley Beecham, Lars Alfredsson, Katayoun Alikhani, Lilyana Amezcua, Till F. M. Andlauer, Maria Ban, Lisa Barcellos, Nadia Barizzone, Tone Berge, Achim Berthele, Stefan Bittner, Steffan BosFarren B. S. Briggs, Stacy Caillier, Peter Calabresi, Domenico Caputo, David Carmona-Burgos, Paola Cavalla, Elisabeth Celius, Gabriel Cerono, Angel Chinea, Tanuja Chitnis, Ferdinando Clarelli, Manuel Comabella, Giancarlo Comi, Chris Cotsapas, Bruce C. A. Cree, Sandra D'Alfonso, Efthimios Dardiotis, Philip De Jager, Silvia Delgado, Benedicte Dubois, Sinah Engel, Federica Esposito, Marzena Fabis-Pedrini, Massimo Filippi, Kathryn Fitzgerald, Christiane Gasperi, Lissette Gomez, Refujia Gomez, Georgios Hadjigeorgiou, Joerg Hamann, Friederike Held, Kimmo Paakkonen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Nature
Volume	619
Issue number	7969
Pages (from-to)	323–331
Number of pages	27
ISSN	0028-0836
DOIs	https://doi.org/10.1038/s41586-023-06250-x
Publication status	Published - 13 Jul 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

3111 Biomedicine

Access to Document

10.1038/s41586-023-06250-x

Cite this

International Multiple Sclerosis Genetics Consortium, MultipleMS Consortium, Harroud, A., Stridh, P. J., McCauley, J. H., Saarela, J., van den Bosch, A. M. R., Engelenburg, H., Beecham, A., Alfredsson, L., Alikhani, K., Amezcua, L., Andlauer, T. F. M., Ban, M., Barcellos, L., Barizzone, N., Berge, T., Berthele, A., Bittner, S., ... Paakkonen, K. (2023). Locus for severity implicates CNS resilience in progression of multiple sclerosis. Nature, 619(7969), 323–331. https://doi.org/10.1038/s41586-023-06250-x

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title = "Locus for severity implicates CNS resilience in progression of multiple sclerosis",

keywords = "Amyotrophic-lateral-sclerosis, Genome-wide association, Disability progression, Transcriptome, Heritability, Statistics, Mechanisms, Mutations, Diseases, Atlas, 3111 Biomedicine",

author = "{International Multiple Sclerosis Genetics Consortium} and {MultipleMS Consortium} and Adil Harroud and Stridh, {Pernilla J.} and McCauley, {Jacob H.} and Janna Saarela and {van den Bosch}, {Aletta M. R.} and Hendrik Engelenburg and Ashley Beecham and Lars Alfredsson and Katayoun Alikhani and Lilyana Amezcua and Andlauer, {Till F. M.} and Maria Ban and Lisa Barcellos and Nadia Barizzone and Tone Berge and Achim Berthele and Stefan Bittner and Steffan Bos and Briggs, {Farren B. S.} and Stacy Caillier and Peter Calabresi and Domenico Caputo and David Carmona-Burgos and Paola Cavalla and Elisabeth Celius and Gabriel Cerono and Angel Chinea and Tanuja Chitnis and Ferdinando Clarelli and Manuel Comabella and Giancarlo Comi and Chris Cotsapas and Cree, {Bruce C. A.} and Sandra D'Alfonso and Efthimios Dardiotis and {De Jager}, Philip and Silvia Delgado and Benedicte Dubois and Sinah Engel and Federica Esposito and Marzena Fabis-Pedrini and Massimo Filippi and Kathryn Fitzgerald and Christiane Gasperi and Lissette Gomez and Refujia Gomez and Georgios Hadjigeorgiou and Joerg Hamann and Friederike Held and Kimmo Paakkonen",

year = "2023",

month = jul,

day = "13",

doi = "10.1038/s41586-023-06250-x",

language = "English",

volume = "619",

pages = "323–331",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research ",

number = "7969",

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International Multiple Sclerosis Genetics Consortium, MultipleMS Consortium, Harroud, A, Stridh, PJ, McCauley, JH, Saarela, J, van den Bosch, AMR, Engelenburg, H, Beecham, A, Alfredsson, L, Alikhani, K, Amezcua, L, Andlauer, TFM, Ban, M, Barcellos, L, Barizzone, N, Berge, T, Berthele, A, Bittner, S, Bos, S, Briggs, FBS, Caillier, S, Calabresi, P, Caputo, D, Carmona-Burgos, D, Cavalla, P, Celius, E, Cerono, G, Chinea, A, Chitnis, T, Clarelli, F, Comabella, M, Comi, G, Cotsapas, C, Cree, BCA, D'Alfonso, S, Dardiotis, E, De Jager, P, Delgado, S, Dubois, B, Engel, S, Esposito, F, Fabis-Pedrini, M, Filippi, M, Fitzgerald, K, Gasperi, C, Gomez, L, Gomez, R, Hadjigeorgiou, G, Hamann, J, Held, F & Paakkonen, K 2023, 'Locus for severity implicates CNS resilience in progression of multiple sclerosis', Nature, vol. 619, no. 7969, pp. 323–331. https://doi.org/10.1038/s41586-023-06250-x

TY - JOUR

T1 - Locus for severity implicates CNS resilience in progression of multiple sclerosis

AU - International Multiple Sclerosis Genetics Consortium

AU - MultipleMS Consortium

AU - Harroud, Adil

AU - Stridh, Pernilla J.

AU - McCauley, Jacob H.

AU - Saarela, Janna

AU - van den Bosch, Aletta M. R.

AU - Engelenburg, Hendrik

AU - Beecham, Ashley

AU - Alfredsson, Lars

AU - Alikhani, Katayoun

AU - Amezcua, Lilyana

AU - Andlauer, Till F. M.

AU - Ban, Maria

AU - Barcellos, Lisa

AU - Barizzone, Nadia

AU - Berge, Tone

AU - Berthele, Achim

AU - Bittner, Stefan

AU - Bos, Steffan

AU - Briggs, Farren B. S.

AU - Caillier, Stacy

AU - Calabresi, Peter

AU - Caputo, Domenico

AU - Carmona-Burgos, David

AU - Cavalla, Paola

AU - Celius, Elisabeth

AU - Cerono, Gabriel

AU - Chinea, Angel

AU - Chitnis, Tanuja

AU - Clarelli, Ferdinando

AU - Comabella, Manuel

AU - Comi, Giancarlo

AU - Cotsapas, Chris

AU - Cree, Bruce C. A.

AU - D'Alfonso, Sandra

AU - Dardiotis, Efthimios

AU - De Jager, Philip

AU - Delgado, Silvia

AU - Dubois, Benedicte

AU - Engel, Sinah

AU - Esposito, Federica

AU - Fabis-Pedrini, Marzena

AU - Filippi, Massimo

AU - Fitzgerald, Kathryn

AU - Gasperi, Christiane

AU - Gomez, Lissette

AU - Gomez, Refujia

AU - Hadjigeorgiou, Georgios

AU - Hamann, Joerg

AU - Held, Friederike

AU - Paakkonen, Kimmo

PY - 2023/7/13

Y1 - 2023/7/13

KW - Amyotrophic-lateral-sclerosis

KW - Genome-wide association

KW - Disability progression

KW - Transcriptome

KW - Heritability

KW - Statistics

KW - Mechanisms

KW - Mutations

KW - Diseases

KW - Atlas

KW - 3111 Biomedicine

U2 - 10.1038/s41586-023-06250-x

DO - 10.1038/s41586-023-06250-x

M3 - Article

C2 - 37380766

SN - 0028-0836

VL - 619

SP - 323

EP - 331

JO - Nature

JF - Nature

IS - 7969

ER -