Long-Term Changes in Cyclosporine Pharmacokinetics After Renal Transplantation in Children: Evidence for Saturable Presystemic Metabolism and Effect of NR1I2 Polymorphism

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Clinical Pharmacology
Volume50
Issue number5
Pages (from-to)581-597
Number of pages17
ISSN0091-2700
DOIs
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed

Fields of Science

  • cyclosporine
  • pediatric renal transplantation
  • population pharmacokinetics
  • pharmacogenetics
  • therapeutic drug monitoring
  • POPULATION PHARMACOKINETICS
  • CALCINEURIN INHIBITOR
  • P-GLYCOPROTEIN
  • RECIPIENTS
  • IMPACT
  • IMMUNOSUPPRESSION
  • PHARMACOGENETICS
  • NEPHROTOXICITY
  • IDENTIFICATION
  • MICROEMULSION
  • 312 Clinical medicine

Cite this

@article{269fb8a2cc7d46259148edf85d8429e4,
title = "Long-Term Changes in Cyclosporine Pharmacokinetics After Renal Transplantation in Children: Evidence for Saturable Presystemic Metabolism and Effect of NR1I2 Polymorphism",
keywords = "cyclosporine, pediatric renal transplantation, population pharmacokinetics, pharmacogenetics, therapeutic drug monitoring, POPULATION PHARMACOKINETICS, CALCINEURIN INHIBITOR, P-GLYCOPROTEIN, RECIPIENTS, IMPACT, IMMUNOSUPPRESSION, PHARMACOGENETICS, NEPHROTOXICITY, IDENTIFICATION, MICROEMULSION, 312 Clinical medicine",
author = "Samuel Fanta and Siv Jonsson and Karlsson, {Mats O.} and Niemi, {Mikko Olavi} and Christer Holmberg and Kalle Hoppu and Janne Backman",
year = "2010",
doi = "10.1177/0091270009348223",
language = "English",
volume = "50",
pages = "581--597",
journal = "Journal of Clinical Pharmacology",
issn = "0091-2700",
publisher = "SAGE SCIENCE PRESS (US)",
number = "5",

}

TY - JOUR

T1 - Long-Term Changes in Cyclosporine Pharmacokinetics After Renal Transplantation in Children: Evidence for Saturable Presystemic Metabolism and Effect of NR1I2 Polymorphism

AU - Fanta, Samuel

AU - Jonsson, Siv

AU - Karlsson, Mats O.

AU - Niemi, Mikko Olavi

AU - Holmberg, Christer

AU - Hoppu, Kalle

AU - Backman, Janne

PY - 2010

Y1 - 2010

KW - cyclosporine

KW - pediatric renal transplantation

KW - population pharmacokinetics

KW - pharmacogenetics

KW - therapeutic drug monitoring

KW - POPULATION PHARMACOKINETICS

KW - CALCINEURIN INHIBITOR

KW - P-GLYCOPROTEIN

KW - RECIPIENTS

KW - IMPACT

KW - IMMUNOSUPPRESSION

KW - PHARMACOGENETICS

KW - NEPHROTOXICITY

KW - IDENTIFICATION

KW - MICROEMULSION

KW - 312 Clinical medicine

U2 - 10.1177/0091270009348223

DO - 10.1177/0091270009348223

M3 - Article

VL - 50

SP - 581

EP - 597

JO - Journal of Clinical Pharmacology

JF - Journal of Clinical Pharmacology

SN - 0091-2700

IS - 5

ER -