Long-Term Changes in Cyclosporine Pharmacokinetics After Renal Transplantation in Children: Evidence for Saturable Presystemic Metabolism and Effect of NR1I2 Polymorphism

Samuel Fanta; Siv Jonsson; Mats O. Karlsson; Mikko Olavi Niemi; Christer Holmberg; Kalle Hoppu; Janne Backman

doi:10.1177/0091270009348223

Long-Term Changes in Cyclosporine Pharmacokinetics After Renal Transplantation in Children: Evidence for Saturable Presystemic Metabolism and Effect of NR1I2 Polymorphism

Samuel Fanta, Siv Jonsson, Mats O. Karlsson, Mikko Olavi Niemi, Christer Holmberg, Kalle Hoppu, Janne Backman

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Journal of Clinical Pharmacology
Volume	50
Issue number	5
Pages (from-to)	581-597
Number of pages	17
ISSN	0091-2700
DOIs	https://doi.org/10.1177/0091270009348223
Publication status	Published - 2010
MoE publication type	A1 Journal article-refereed

Fields of Science

cyclosporine
pediatric renal transplantation
population pharmacokinetics
pharmacogenetics
therapeutic drug monitoring
POPULATION PHARMACOKINETICS
CALCINEURIN INHIBITOR
P-GLYCOPROTEIN
RECIPIENTS
IMPACT
IMMUNOSUPPRESSION
PHARMACOGENETICS
NEPHROTOXICITY
IDENTIFICATION
MICROEMULSION
312 Clinical medicine

Access to Document

10.1177/0091270009348223

Cite this

Fanta, Samuel ; Jonsson, Siv ; Karlsson, Mats O. ; Niemi, Mikko Olavi ; Holmberg, Christer ; Hoppu, Kalle ; Backman, Janne. / Long-Term Changes in Cyclosporine Pharmacokinetics After Renal Transplantation in Children: Evidence for Saturable Presystemic Metabolism and Effect of NR1I2 Polymorphism. In: Journal of Clinical Pharmacology. 2010 ; Vol. 50, No. 5. pp. 581-597.

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title = "Long-Term Changes in Cyclosporine Pharmacokinetics After Renal Transplantation in Children: Evidence for Saturable Presystemic Metabolism and Effect of NR1I2 Polymorphism",

keywords = "cyclosporine, pediatric renal transplantation, population pharmacokinetics, pharmacogenetics, therapeutic drug monitoring, POPULATION PHARMACOKINETICS, CALCINEURIN INHIBITOR, P-GLYCOPROTEIN, RECIPIENTS, IMPACT, IMMUNOSUPPRESSION, PHARMACOGENETICS, NEPHROTOXICITY, IDENTIFICATION, MICROEMULSION, 312 Clinical medicine",

author = "Samuel Fanta and Siv Jonsson and Karlsson, {Mats O.} and Niemi, {Mikko Olavi} and Christer Holmberg and Kalle Hoppu and Janne Backman",

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doi = "10.1177/0091270009348223",

language = "English",

volume = "50",

pages = "581--597",

journal = "Journal of Clinical Pharmacology",

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Long-Term Changes in Cyclosporine Pharmacokinetics After Renal Transplantation in Children: Evidence for Saturable Presystemic Metabolism and Effect of NR1I2 Polymorphism. / Fanta, Samuel; Jonsson, Siv; Karlsson, Mats O.; Niemi, Mikko Olavi ; Holmberg, Christer ; Hoppu, Kalle ; Backman, Janne.

In: Journal of Clinical Pharmacology, Vol. 50, No. 5, 2010, p. 581-597.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Long-Term Changes in Cyclosporine Pharmacokinetics After Renal Transplantation in Children: Evidence for Saturable Presystemic Metabolism and Effect of NR1I2 Polymorphism

AU - Fanta, Samuel

AU - Jonsson, Siv

AU - Karlsson, Mats O.

AU - Niemi, Mikko Olavi

AU - Holmberg, Christer

AU - Hoppu, Kalle

AU - Backman, Janne

PY - 2010

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KW - cyclosporine

KW - pediatric renal transplantation

KW - population pharmacokinetics

KW - pharmacogenetics

KW - therapeutic drug monitoring

KW - POPULATION PHARMACOKINETICS

KW - CALCINEURIN INHIBITOR

KW - P-GLYCOPROTEIN

KW - RECIPIENTS

KW - IMPACT

KW - IMMUNOSUPPRESSION

KW - PHARMACOGENETICS

KW - NEPHROTOXICITY

KW - IDENTIFICATION

KW - MICROEMULSION

KW - 312 Clinical medicine

U2 - 10.1177/0091270009348223

DO - 10.1177/0091270009348223

M3 - Article

VL - 50

SP - 581

EP - 597

JO - Journal of Clinical Pharmacology

JF - Journal of Clinical Pharmacology

SN - 0091-2700

IS - 5

ER -