Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1

Olli Matilainen; Ana R. S. Ribeiro; Jens Verbeeren; Murat Cetinbas; Heini Sood; Ruslan Sadreyev; Susana M. D. A. Garcia

doi:10.1093/genetics/iyab114

Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1

Olli Matilainen, Ana R. S. Ribeiro, Jens Verbeeren, Murat Cetinbas, Heini Sood, Ruslan Sadreyev, Susana M. D. A. Garcia

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	114
Journal	Genetics
Volume	219
Issue number	2
Number of pages	13
ISSN	0016-6731
DOIs	https://doi.org/10.1093/genetics/iyab114
Publication status	Published - Oct 2021
MoE publication type	A1 Journal article-refereed

Fields of Science

Muscleblind splicing factor
C. elegans
lifespan
p38 MAPK
PMK-1
ATF-1
SKN-1
mitochondrial stress
INNATE IMMUNE-RESPONSES
MITOCHONDRIAL DYSFUNCTION
FACTOR SKN-1
KINASE
RNA
MAPK
PROTEINS
PATHWAY
STRESS
EXPRESSION
1184 Genetics, developmental biology, physiology

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10.1093/genetics/iyab114Licence: CC BY

iyab114Final published version, 1.03 MBLicence: CC BY

EpiProt: Epigenome Activated Proteostasis
Matilainen, O. (Project manager), Salgado Ribeiro, A. R. (Participant) & Shrestha, B. (Participant)
Valtion perusrahoitus/hankkeet, Academy of Finland
01/01/2019 → 31/12/2021
Project: University of Helsinki Three-Year Research Project

Cite this

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title = "Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1",

keywords = "Muscleblind splicing factor, C. elegans, lifespan, p38 MAPK, PMK-1, ATF-1, SKN-1, mitochondrial stress, INNATE IMMUNE-RESPONSES, MITOCHONDRIAL DYSFUNCTION, FACTOR SKN-1, KINASE, RNA, MAPK, PROTEINS, PATHWAY, STRESS, EXPRESSION, 1184 Genetics, developmental biology, physiology",

author = "Olli Matilainen and Ribeiro, {Ana R. S.} and Jens Verbeeren and Murat Cetinbas and Heini Sood and Ruslan Sadreyev and Garcia, {Susana M. D. A.}",

year = "2021",

month = oct,

doi = "10.1093/genetics/iyab114",

language = "English",

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journal = "Genetics",

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T1 - Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1

AU - Matilainen, Olli

AU - Ribeiro, Ana R. S.

AU - Verbeeren, Jens

AU - Cetinbas, Murat

AU - Sood, Heini

AU - Sadreyev, Ruslan

AU - Garcia, Susana M. D. A.

PY - 2021/10

Y1 - 2021/10

KW - Muscleblind splicing factor

KW - C. elegans

KW - lifespan

KW - p38 MAPK

KW - PMK-1

KW - ATF-1

KW - SKN-1

KW - mitochondrial stress

KW - INNATE IMMUNE-RESPONSES

KW - MITOCHONDRIAL DYSFUNCTION

KW - FACTOR SKN-1

KW - KINASE

KW - RNA

KW - MAPK

KW - PROTEINS

KW - PATHWAY

KW - STRESS

KW - EXPRESSION

KW - 1184 Genetics, developmental biology, physiology

U2 - 10.1093/genetics/iyab114

DO - 10.1093/genetics/iyab114

M3 - Article

SN - 0016-6731

VL - 219

JO - Genetics

JF - Genetics

IS - 2

M1 - 114

ER -

Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1

Fields of Science

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Projects

EpiProt: Epigenome Activated Proteostasis

Cite this