Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites

Mohammad Majharul Islam; Iryna Hlushchenko; Simon Pfisterer

doi:10.3389/fcell.2022.826379

Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites

Mohammad Majharul Islam, Iryna Hlushchenko, Simon Pfisterer

Research output: Contribution to journal › Review Article › peer-review

Abstract

Low-density lipoprotein (LDL) internalization, degradation, and receptor recycling is a fundamental process underlying hypercholesterolemia, a high blood cholesterol concentration, affecting more than 40% of the western population. Membrane contact sites influence endosomal dynamics, plasma membrane lipid composition, and cellular cholesterol distribution. However, if we focus on LDL-related trafficking events we mostly discuss them in an isolated fashion, without cellular context. It is our goal to change this perspective and to highlight that all steps from LDL internalization to receptor recycling are likely associated with dynamic membrane contact sites in which endosomes engage with the endoplasmic reticulum and other organelles.

Original language	English
Article number	826379
Journal	Frontiers in Cell and Developmental Biology
Volume	10
Number of pages	6
ISSN	2296-634X
DOIs	https://doi.org/10.3389/fcell.2022.826379 https://doi.org/10.3389/fcell.2022.826379
Publication status	Published - 24 Jan 2022
MoE publication type	A2 Review article in a scientific journal

Fields of Science

BINDING
CHOLESTEROL TRANSPORT
EGRESS
ENDOSOMES
ER CONTACT
INSIGHTS
MODULATES ENDOCYTOSIS
NIR2
PLASMA-MEMBRANE
TRAFFICKING
endosomal degradation
endosomal recycling
hypercholesterolemia
low-density lipoprotein (LDL)
low-density lipoprotein receptor (LDLR)
membrane contact site
3111 Biomedicine
1182 Biochemistry, cell and molecular biology

Access to Document

10.3389/fcell.2022.826379
10.3389/fcell.2022.826379Licence: CC BY

fcell-10-826379Final published version, 970 KBLicence: CC BY

Cite this

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title = "Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites",

abstract = "Low-density lipoprotein (LDL) internalization, degradation, and receptor recycling is a fundamental process underlying hypercholesterolemia, a high blood cholesterol concentration, affecting more than 40% of the western population. Membrane contact sites influence endosomal dynamics, plasma membrane lipid composition, and cellular cholesterol distribution. However, if we focus on LDL-related trafficking events we mostly discuss them in an isolated fashion, without cellular context. It is our goal to change this perspective and to highlight that all steps from LDL internalization to receptor recycling are likely associated with dynamic membrane contact sites in which endosomes engage with the endoplasmic reticulum and other organelles.",

keywords = "BINDING, CHOLESTEROL TRANSPORT, EGRESS, ENDOSOMES, ER CONTACT, INSIGHTS, MODULATES ENDOCYTOSIS, NIR2, PLASMA-MEMBRANE, TRAFFICKING, endosomal degradation, endosomal recycling, hypercholesterolemia, low-density lipoprotein (LDL), low-density lipoprotein receptor (LDLR), membrane contact site, 3111 Biomedicine, 1182 Biochemistry, cell and molecular biology",

author = "Islam, {Mohammad Majharul} and Iryna Hlushchenko and Simon Pfisterer",

year = "2022",

month = jan,

day = "24",

doi = "10.3389/fcell.2022.826379",

language = "English",

volume = "10",

journal = "Frontiers in Cell and Developmental Biology",

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TY - JOUR

T1 - Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites

AU - Islam, Mohammad Majharul

AU - Hlushchenko, Iryna

AU - Pfisterer, Simon

PY - 2022/1/24

Y1 - 2022/1/24

N2 - Low-density lipoprotein (LDL) internalization, degradation, and receptor recycling is a fundamental process underlying hypercholesterolemia, a high blood cholesterol concentration, affecting more than 40% of the western population. Membrane contact sites influence endosomal dynamics, plasma membrane lipid composition, and cellular cholesterol distribution. However, if we focus on LDL-related trafficking events we mostly discuss them in an isolated fashion, without cellular context. It is our goal to change this perspective and to highlight that all steps from LDL internalization to receptor recycling are likely associated with dynamic membrane contact sites in which endosomes engage with the endoplasmic reticulum and other organelles.

AB - Low-density lipoprotein (LDL) internalization, degradation, and receptor recycling is a fundamental process underlying hypercholesterolemia, a high blood cholesterol concentration, affecting more than 40% of the western population. Membrane contact sites influence endosomal dynamics, plasma membrane lipid composition, and cellular cholesterol distribution. However, if we focus on LDL-related trafficking events we mostly discuss them in an isolated fashion, without cellular context. It is our goal to change this perspective and to highlight that all steps from LDL internalization to receptor recycling are likely associated with dynamic membrane contact sites in which endosomes engage with the endoplasmic reticulum and other organelles.

KW - BINDING

KW - CHOLESTEROL TRANSPORT

KW - EGRESS

KW - ENDOSOMES

KW - ER CONTACT

KW - INSIGHTS

KW - MODULATES ENDOCYTOSIS

KW - NIR2

KW - PLASMA-MEMBRANE

KW - TRAFFICKING

KW - endosomal degradation

KW - endosomal recycling

KW - hypercholesterolemia

KW - low-density lipoprotein (LDL)

KW - low-density lipoprotein receptor (LDLR)

KW - membrane contact site

KW - 3111 Biomedicine

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.3389/fcell.2022.826379

DO - 10.3389/fcell.2022.826379

M3 - Review Article

SN - 2296-634X

VL - 10

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

M1 - 826379

ER -