Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

Irem Ozkan-Dagliyan, J. Nathaniel Diehl, Samuel D. George, Antje Schaefer, Bjoern Papke, Kathleen Klotz-Noack, Andrew M. Waters, Craig M. Goodwin, Prson Gautam, Mariaelena Pierobon, Sen Peng, Thomas S. K. Gilbert, Kevin H. Lin, Onur Dagliyan, Krister Wennerberg, Emanuel F. Petricoin, Nhan L. Tran, Shripad Bhagwat, Ramon Tiu, Sheng-Bin PengLaura E. Herring, Lee M. Graves, Christine Sers, Kris C. Wood, Adrienne D. Cox, Channing J. Der

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
Article number107764
JournalCell Reports
Volume31
Issue number11
Number of pages27
ISSN2211-1247
DOIs
Publication statusPublished - 16 Jun 2020
MoE publication typeA1 Journal article-refereed

Fields of Science

  • CELL LUNG-CANCER
  • ADAPTIVE RESISTANCE
  • SIGNALING PATHWAYS
  • PANCREATIC-CANCER
  • ONCOGENIC KRAS
  • COMBINED BRAF
  • C-RAF
  • PHOSPHORYLATION
  • DEGRADATION
  • ENRICHMENT
  • 1182 Biochemistry, cell and molecular biology

Cite this

Ozkan-Dagliyan, I., Diehl, J. N., George, S. D., Schaefer, A., Papke, B., Klotz-Noack, K., Waters, A. M., Goodwin, C. M., Gautam, P., Pierobon, M., Peng, S., Gilbert, T. S. K., Lin, K. H., Dagliyan, O., Wennerberg, K., Petricoin, E. F., Tran, N. L., Bhagwat, S., Tiu, R., ... Der, C. J. (2020). Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers. Cell Reports, 31(11), [107764]. https://doi.org/10.1016/j.celrep.2020.107764