Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Emilia A. Korhonen; Aino Murtomäki; Sawan Kumar Jha; Andrey Anisimov; Anne Pink; Yan Zhang; Simon Stritt; Inam Liaqat; Lukas Stanczuk; Laura Alderfer; Zhiliang Sun; Emmi Kapiainen; Abhishek Singh; Ibrahim Sultan; Anni Lantta; Veli Matti Leppänen; Lauri Eklund; Yulong He; Hellmut G. Augustin; Kari Vaahtomeri; Pipsa Saharinen; Taija Makinen; Kari Alitalo

doi:10.1172/JCI155478

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Emilia A. Korhonen, Aino Murtomäki, Sawan Kumar Jha, Andrey Anisimov, Anne Pink, Yan Zhang, Simon Stritt, Inam Liaqat, Lukas Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, Veli Matti Leppänen, Lauri Eklund, Yulong He, Hellmut G. Augustin, Kari VaahtomeriPipsa Saharinen, Taija Makinen, Kari Alitalo

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	e155478
Journal	Journal of Clinical Investigation
Volume	132
Issue number	15
Number of pages	18
ISSN	0021-9738
DOIs	https://doi.org/10.1172/JCI155478
Publication status	Published - 1 Aug 2022
MoE publication type	A1 Journal article-refereed

Bibliographical note

Publisher Copyright:
© 2022 American Society for Clinical Investigation. All rights reserved.

Fields of Science

3111 Biomedicine
1182 Biochemistry, cell and molecular biology
LYMPHATIC VESSEL DEVELOPMENT
GROWTH-FACTOR-C
PHOSPHATIDYLINOSITOL 3-KINASE
GENE-EXPRESSION
ANGIOPOIETIN 2
RECEPTOR
TIE1
VALVE
ANGIOGENESIS
VASCULATURE

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10.1172/JCI155478

JCI155478.v2Final published version, 29.5 MBLicence: CC BY

Cite this

Korhonen, E. A., Murtomäki, A., Jha, S. K., Anisimov, A., Pink, A., Zhang, Y., Stritt, S., Liaqat, I., Stanczuk, L., Alderfer, L., Sun, Z., Kapiainen, E., Singh, A., Sultan, I., Lantta, A., Leppänen, V. M., Eklund, L., He, Y., Augustin, H. G., ... Alitalo, K. (2022). Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression. Journal of Clinical Investigation, 132(15), Article e155478. https://doi.org/10.1172/JCI155478

@article{038e39289aaf4ee99f4649d90d97068b,

title = "Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression",

keywords = "3111 Biomedicine, 1182 Biochemistry, cell and molecular biology, LYMPHATIC VESSEL DEVELOPMENT, GROWTH-FACTOR-C, PHOSPHATIDYLINOSITOL 3-KINASE, GENE-EXPRESSION, ANGIOPOIETIN 2, RECEPTOR, TIE1, VALVE, ANGIOGENESIS, VASCULATURE",

author = "Korhonen, {Emilia A.} and Aino Murtom{\"a}ki and Jha, {Sawan Kumar} and Andrey Anisimov and Anne Pink and Yan Zhang and Simon Stritt and Inam Liaqat and Lukas Stanczuk and Laura Alderfer and Zhiliang Sun and Emmi Kapiainen and Abhishek Singh and Ibrahim Sultan and Anni Lantta and Lepp{\"a}nen, {Veli Matti} and Lauri Eklund and Yulong He and Augustin, {Hellmut G.} and Kari Vaahtomeri and Pipsa Saharinen and Taija Makinen and Kari Alitalo",

year = "2022",

month = aug,

day = "1",

doi = "10.1172/JCI155478",

language = "English",

volume = "132",

journal = "Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "AMERICAN SOCIETY FOR CLINICAL INVESTIGATION",

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Korhonen, EA, Murtomäki, A, Jha, SK, Anisimov, A , Pink, A, Zhang, Y, Stritt, S, Liaqat, I, Stanczuk, L, Alderfer, L, Sun, Z, Kapiainen, E, Singh, A, Sultan, I, Lantta, A, Leppänen, VM, Eklund, L, He, Y, Augustin, HG, Vaahtomeri, K , Saharinen, P, Makinen, T & Alitalo, K 2022, 'Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression', Journal of Clinical Investigation, vol. 132, no. 15, e155478. https://doi.org/10.1172/JCI155478

TY - JOUR

T1 - Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

AU - Korhonen, Emilia A.

AU - Murtomäki, Aino

AU - Jha, Sawan Kumar

AU - Anisimov, Andrey

AU - Pink, Anne

AU - Zhang, Yan

AU - Stritt, Simon

AU - Liaqat, Inam

AU - Stanczuk, Lukas

AU - Alderfer, Laura

AU - Sun, Zhiliang

AU - Kapiainen, Emmi

AU - Singh, Abhishek

AU - Sultan, Ibrahim

AU - Lantta, Anni

AU - Leppänen, Veli Matti

AU - Eklund, Lauri

AU - He, Yulong

AU - Augustin, Hellmut G.

AU - Vaahtomeri, Kari

AU - Saharinen, Pipsa

AU - Makinen, Taija

AU - Alitalo, Kari

PY - 2022/8/1

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KW - 1182 Biochemistry, cell and molecular biology

KW - LYMPHATIC VESSEL DEVELOPMENT

KW - GROWTH-FACTOR-C

KW - PHOSPHATIDYLINOSITOL 3-KINASE

KW - GENE-EXPRESSION

KW - ANGIOPOIETIN 2

KW - RECEPTOR

KW - TIE1

KW - VALVE

KW - ANGIOGENESIS

KW - VASCULATURE

U2 - 10.1172/JCI155478

DO - 10.1172/JCI155478

M3 - Article

C2 - 35763346

AN - SCOPUS:85135246300

SN - 0021-9738

VL - 132

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 15

M1 - e155478

ER -