Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and beta 1-integrin activation

Pirita Pekkonen; Sanni Alve; Giuseppe Balistreri; Silvia Gramolelli; Olga Tatti-Bugaeva; Ilkka Paatero; Otso Niiranen; Krista Tuohinto; Nina Perala; Adewale Taiwo; Nadezhda Zinovkina; Pauliina Repo; Katherine Icay; Joanna Ivaska; Pipsa Saharinen; Sampsa Hautaniemi; Kaisa Lehti; Paivi M. Ojala

doi:10.7554/eLife.32490

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and beta 1-integrin activation

Pirita Pekkonen, Sanni Alve, Giuseppe Balistreri, Silvia Gramolelli, Olga Tatti-Bugaeva, Ilkka Paatero, Otso Niiranen, Krista Tuohinto, Nina Perala, Adewale Taiwo, Nadezhda Zinovkina, Pauliina Repo, Katherine Icay, Joanna Ivaska, Pipsa Saharinen, Sampsa Hautaniemi, Kaisa Lehti, Paivi M. Ojala

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	32490
Journal	eLife
Volume	7
Number of pages	28
ISSN	2050-084X
DOIs	https://doi.org/10.7554/eLife.32490
Publication status	Published - 1 May 2018
MoE publication type	A1 Journal article-refereed

Fields of Science

TO-MESENCHYMAL TRANSITION
TUMOR PROGRESSION
NODE METASTASIS
CELL-ADHESION
CANCER
METALLOPROTEINASES
EXPRESSION
PLATFORM
VESSELS
CCR7
3111 Biomedicine

Access to Document

10.7554/eLife.32490Licence: CC BY

Lymphatic endothelium stimulatesFinal published version, 20.6 MBLicence: CC BY

Cite this

Pekkonen, P., Alve, S., Balistreri, G., Gramolelli, S., Tatti-Bugaeva, O., Paatero, I., Niiranen, O., Tuohinto, K., Perala, N., Taiwo, A., Zinovkina, N., Repo, P., Icay, K., Ivaska, J., Saharinen, P., Hautaniemi, S., Lehti, K., & Ojala, P. M. (2018). Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and beta 1-integrin activation. eLife, 7, [32490]. https://doi.org/10.7554/eLife.32490

Pekkonen, Pirita ; Alve, Sanni ; Balistreri, Giuseppe ; Gramolelli, Silvia ; Tatti-Bugaeva, Olga ; Paatero, Ilkka ; Niiranen, Otso ; Tuohinto, Krista ; Perala, Nina ; Taiwo, Adewale ; Zinovkina, Nadezhda ; Repo, Pauliina ; Icay, Katherine ; Ivaska, Joanna ; Saharinen, Pipsa ; Hautaniemi, Sampsa ; Lehti, Kaisa ; Ojala, Paivi M. / Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and beta 1-integrin activation. In: eLife. 2018 ; Vol. 7.

@article{cba1f27711694721b243c8325363fca1,

title = "Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and beta 1-integrin activation",

keywords = "TO-MESENCHYMAL TRANSITION, TUMOR PROGRESSION, NODE METASTASIS, CELL-ADHESION, CANCER, METALLOPROTEINASES, EXPRESSION, PLATFORM, VESSELS, CCR7, 3111 Biomedicine",

author = "Pirita Pekkonen and Sanni Alve and Giuseppe Balistreri and Silvia Gramolelli and Olga Tatti-Bugaeva and Ilkka Paatero and Otso Niiranen and Krista Tuohinto and Nina Perala and Adewale Taiwo and Nadezhda Zinovkina and Pauliina Repo and Katherine Icay and Joanna Ivaska and Pipsa Saharinen and Sampsa Hautaniemi and Kaisa Lehti and Ojala, {Paivi M.}",

year = "2018",

month = may,

day = "1",

doi = "10.7554/eLife.32490",

language = "English",

volume = "7",

journal = "eLife",

issn = "2050-084X",

publisher = "ELIFE SCIENCES PUBLICATIONS LTD",

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Pekkonen, P, Alve, S , Balistreri, G , Gramolelli, S, Tatti-Bugaeva, O, Paatero, I, Niiranen, O, Tuohinto, K, Perala, N, Taiwo, A, Zinovkina, N, Repo, P, Icay, K, Ivaska, J, Saharinen, P , Hautaniemi, S , Lehti, K & Ojala, PM 2018, 'Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and beta 1-integrin activation', eLife, vol. 7, 32490. https://doi.org/10.7554/eLife.32490

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and beta 1-integrin activation. / Pekkonen, Pirita; Alve, Sanni ; Balistreri, Giuseppe ; Gramolelli, Silvia; Tatti-Bugaeva, Olga; Paatero, Ilkka; Niiranen, Otso; Tuohinto, Krista; Perala, Nina; Taiwo, Adewale; Zinovkina, Nadezhda; Repo, Pauliina; Icay, Katherine; Ivaska, Joanna; Saharinen, Pipsa ; Hautaniemi, Sampsa ; Lehti, Kaisa ; Ojala, Paivi M.

In: eLife, Vol. 7, 32490, 01.05.2018.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and beta 1-integrin activation

AU - Pekkonen, Pirita

AU - Alve, Sanni

AU - Balistreri, Giuseppe

AU - Gramolelli, Silvia

AU - Tatti-Bugaeva, Olga

AU - Paatero, Ilkka

AU - Niiranen, Otso

AU - Tuohinto, Krista

AU - Perala, Nina

AU - Taiwo, Adewale

AU - Zinovkina, Nadezhda

AU - Repo, Pauliina

AU - Icay, Katherine

AU - Ivaska, Joanna

AU - Saharinen, Pipsa

AU - Hautaniemi, Sampsa

AU - Lehti, Kaisa

AU - Ojala, Paivi M.

PY - 2018/5/1

Y1 - 2018/5/1

KW - TO-MESENCHYMAL TRANSITION

KW - TUMOR PROGRESSION

KW - NODE METASTASIS

KW - CELL-ADHESION

KW - CANCER

KW - METALLOPROTEINASES

KW - EXPRESSION

KW - PLATFORM

KW - VESSELS

KW - CCR7

KW - 3111 Biomedicine

U2 - 10.7554/eLife.32490

DO - 10.7554/eLife.32490

M3 - Article

VL - 7

JO - eLife

JF - eLife

SN - 2050-084X

M1 - 32490

ER -