Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking

Carolin Schmidtke, Stephan Tiede, Melanie Thelen, Reijo Käkelä, Sabrina Jabs, Georgia Makrypidi, Marc Sylvester, Michaela Schweizer, Ingke Braren, Nahal Brocke-Ahmadinejad, Susan L. Cotman, Angela Schulz, Volkmar Gieselmann, Thomas Braulke

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Biological Chemistry
Volume294
Issue number24
Pages (from-to)9592-9604
Number of pages13
ISSN0021-9258
DOIs
Publication statusPublished - 14 Jun 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • protein sorting
  • trafficking
  • lysosome
  • neurodegenerative disease
  • lipid droplet
  • lipid metabolism
  • endocytosis
  • electron microscopy (EM)
  • mannose 6-phosphate receptors
  • pH regulation
  • proteomics
  • membrane protein
  • NEURONAL-CEROID-LIPOFUSCINOSIS
  • BATTEN-DISEASE GENE
  • CLN3
  • RECEPTOR
  • BIOGENESIS
  • PROTEINS
  • BTN1
  • DEPOSITION
  • TRANSPORT
  • PATHOLOGY
  • 1182 Biochemistry, cell and molecular biology

Cite this

Schmidtke, Carolin ; Tiede, Stephan ; Thelen, Melanie ; Käkelä, Reijo ; Jabs, Sabrina ; Makrypidi, Georgia ; Sylvester, Marc ; Schweizer, Michaela ; Braren, Ingke ; Brocke-Ahmadinejad, Nahal ; Cotman, Susan L. ; Schulz, Angela ; Gieselmann, Volkmar ; Braulke, Thomas. / Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking. In: Journal of Biological Chemistry. 2019 ; Vol. 294, No. 24. pp. 9592-9604.
@article{f61bb15e1fda4c888f1a5a06ca18b125,
title = "Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking",
keywords = "protein sorting, trafficking, lysosome, neurodegenerative disease, lipid droplet, lipid metabolism, endocytosis, electron microscopy (EM), mannose 6-phosphate receptors, pH regulation, proteomics, membrane protein, NEURONAL-CEROID-LIPOFUSCINOSIS, BATTEN-DISEASE GENE, CLN3, RECEPTOR, BIOGENESIS, PROTEINS, BTN1, DEPOSITION, TRANSPORT, PATHOLOGY, 1182 Biochemistry, cell and molecular biology",
author = "Carolin Schmidtke and Stephan Tiede and Melanie Thelen and Reijo K{\"a}kel{\"a} and Sabrina Jabs and Georgia Makrypidi and Marc Sylvester and Michaela Schweizer and Ingke Braren and Nahal Brocke-Ahmadinejad and Cotman, {Susan L.} and Angela Schulz and Volkmar Gieselmann and Thomas Braulke",
year = "2019",
month = "6",
day = "14",
doi = "10.1074/jbc.RA119.008852",
language = "English",
volume = "294",
pages = "9592--9604",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology",
number = "24",

}

Schmidtke, C, Tiede, S, Thelen, M, Käkelä, R, Jabs, S, Makrypidi, G, Sylvester, M, Schweizer, M, Braren, I, Brocke-Ahmadinejad, N, Cotman, SL, Schulz, A, Gieselmann, V & Braulke, T 2019, 'Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking', Journal of Biological Chemistry, vol. 294, no. 24, pp. 9592-9604. https://doi.org/10.1074/jbc.RA119.008852

Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking. / Schmidtke, Carolin; Tiede, Stephan; Thelen, Melanie; Käkelä, Reijo; Jabs, Sabrina; Makrypidi, Georgia; Sylvester, Marc; Schweizer, Michaela; Braren, Ingke; Brocke-Ahmadinejad, Nahal; Cotman, Susan L.; Schulz, Angela; Gieselmann, Volkmar; Braulke, Thomas.

In: Journal of Biological Chemistry, Vol. 294, No. 24, 14.06.2019, p. 9592-9604.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking

AU - Schmidtke, Carolin

AU - Tiede, Stephan

AU - Thelen, Melanie

AU - Käkelä, Reijo

AU - Jabs, Sabrina

AU - Makrypidi, Georgia

AU - Sylvester, Marc

AU - Schweizer, Michaela

AU - Braren, Ingke

AU - Brocke-Ahmadinejad, Nahal

AU - Cotman, Susan L.

AU - Schulz, Angela

AU - Gieselmann, Volkmar

AU - Braulke, Thomas

PY - 2019/6/14

Y1 - 2019/6/14

KW - protein sorting

KW - trafficking

KW - lysosome

KW - neurodegenerative disease

KW - lipid droplet

KW - lipid metabolism

KW - endocytosis

KW - electron microscopy (EM)

KW - mannose 6-phosphate receptors

KW - pH regulation

KW - proteomics

KW - membrane protein

KW - NEURONAL-CEROID-LIPOFUSCINOSIS

KW - BATTEN-DISEASE GENE

KW - CLN3

KW - RECEPTOR

KW - BIOGENESIS

KW - PROTEINS

KW - BTN1

KW - DEPOSITION

KW - TRANSPORT

KW - PATHOLOGY

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1074/jbc.RA119.008852

DO - 10.1074/jbc.RA119.008852

M3 - Article

VL - 294

SP - 9592

EP - 9604

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 24

ER -