Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking

Carolin Schmidtke, Stephan Tiede, Melanie Thelen, Reijo Käkelä, Sabrina Jabs, Georgia Makrypidi, Marc Sylvester, Michaela Schweizer, Ingke Braren, Nahal Brocke-Ahmadinejad, Susan L. Cotman, Angela Schulz, Volkmar Gieselmann, Thomas Braulke

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Biological Chemistry
Volume294
Issue number24
Pages (from-to)9592-9604
Number of pages13
ISSN0021-9258
DOIs
Publication statusPublished - 14 Jun 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • protein sorting
  • trafficking
  • lysosome
  • neurodegenerative disease
  • lipid droplet
  • lipid metabolism
  • endocytosis
  • electron microscopy (EM)
  • mannose 6-phosphate receptors
  • pH regulation
  • proteomics
  • membrane protein
  • NEURONAL-CEROID-LIPOFUSCINOSIS
  • BATTEN-DISEASE GENE
  • CLN3
  • RECEPTOR
  • BIOGENESIS
  • PROTEINS
  • BTN1
  • DEPOSITION
  • TRANSPORT
  • PATHOLOGY
  • 1182 Biochemistry, cell and molecular biology

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