MANF protects human pancreatic beta cells against stress-induced cell death

Elina Hakonen, Vikash Chandra, Christopher L. Fogarty, Nancy Yiu-Lin Yu, Jarkko Ustinov, Shintaro Katayama, Emilia Galli, Tatiana Danilova, Paivi Lindholm, Aki Vartiainen, Elisabet Einarsdottir, Kaarel Krjutskov, Juha Kere, Mart Saarma, Maria Lindahl, Timo Otonkoski

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalDiabetologia
Volume61
Issue number10
Pages (from-to)2202-2214
Number of pages13
ISSN0012-186X
DOIs
Publication statusPublished - Oct 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Beta cell proliferation
  • Beta cell protection
  • Endoplasmic reticulum stress
  • Mesencephalic astrocyte-derived neurotrophic factor (MANF)
  • NF-kappa B
  • NF-KAPPA-B
  • ENDOPLASMIC-RETICULUM STRESS
  • NEUROTROPHIC FACTOR MANF
  • DIFFERENTIAL EXPRESSION
  • INSULIN-SECRETION
  • ER STRESS
  • TYPE-1
  • PROLIFERATION
  • TRANSCRIPTOME
  • NORMALIZATION
  • 3121 Internal medicine

Cite this

Hakonen, Elina ; Chandra, Vikash ; Fogarty, Christopher L. ; Yu, Nancy Yiu-Lin ; Ustinov, Jarkko ; Katayama, Shintaro ; Galli, Emilia ; Danilova, Tatiana ; Lindholm, Paivi ; Vartiainen, Aki ; Einarsdottir, Elisabet ; Krjutskov, Kaarel ; Kere, Juha ; Saarma, Mart ; Lindahl, Maria ; Otonkoski, Timo. / MANF protects human pancreatic beta cells against stress-induced cell death. In: Diabetologia. 2018 ; Vol. 61, No. 10. pp. 2202-2214.
@article{c98bdb2344c2409ca2051e2700d6542a,
title = "MANF protects human pancreatic beta cells against stress-induced cell death",
keywords = "Beta cell proliferation, Beta cell protection, Endoplasmic reticulum stress, Mesencephalic astrocyte-derived neurotrophic factor (MANF), NF-kappa B, NF-KAPPA-B, ENDOPLASMIC-RETICULUM STRESS, NEUROTROPHIC FACTOR MANF, DIFFERENTIAL EXPRESSION, INSULIN-SECRETION, ER STRESS, TYPE-1, PROLIFERATION, TRANSCRIPTOME, NORMALIZATION, 3121 Internal medicine",
author = "Elina Hakonen and Vikash Chandra and Fogarty, {Christopher L.} and Yu, {Nancy Yiu-Lin} and Jarkko Ustinov and Shintaro Katayama and Emilia Galli and Tatiana Danilova and Paivi Lindholm and Aki Vartiainen and Elisabet Einarsdottir and Kaarel Krjutskov and Juha Kere and Mart Saarma and Maria Lindahl and Timo Otonkoski",
year = "2018",
month = "10",
doi = "10.1007/s00125-018-4687-y",
language = "English",
volume = "61",
pages = "2202--2214",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "10",

}

MANF protects human pancreatic beta cells against stress-induced cell death. / Hakonen, Elina; Chandra, Vikash; Fogarty, Christopher L.; Yu, Nancy Yiu-Lin; Ustinov, Jarkko; Katayama, Shintaro; Galli, Emilia; Danilova, Tatiana; Lindholm, Paivi; Vartiainen, Aki; Einarsdottir, Elisabet; Krjutskov, Kaarel; Kere, Juha; Saarma, Mart; Lindahl, Maria; Otonkoski, Timo.

In: Diabetologia, Vol. 61, No. 10, 10.2018, p. 2202-2214.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - MANF protects human pancreatic beta cells against stress-induced cell death

AU - Hakonen, Elina

AU - Chandra, Vikash

AU - Fogarty, Christopher L.

AU - Yu, Nancy Yiu-Lin

AU - Ustinov, Jarkko

AU - Katayama, Shintaro

AU - Galli, Emilia

AU - Danilova, Tatiana

AU - Lindholm, Paivi

AU - Vartiainen, Aki

AU - Einarsdottir, Elisabet

AU - Krjutskov, Kaarel

AU - Kere, Juha

AU - Saarma, Mart

AU - Lindahl, Maria

AU - Otonkoski, Timo

PY - 2018/10

Y1 - 2018/10

KW - Beta cell proliferation

KW - Beta cell protection

KW - Endoplasmic reticulum stress

KW - Mesencephalic astrocyte-derived neurotrophic factor (MANF)

KW - NF-kappa B

KW - NF-KAPPA-B

KW - ENDOPLASMIC-RETICULUM STRESS

KW - NEUROTROPHIC FACTOR MANF

KW - DIFFERENTIAL EXPRESSION

KW - INSULIN-SECRETION

KW - ER STRESS

KW - TYPE-1

KW - PROLIFERATION

KW - TRANSCRIPTOME

KW - NORMALIZATION

KW - 3121 Internal medicine

U2 - 10.1007/s00125-018-4687-y

DO - 10.1007/s00125-018-4687-y

M3 - Article

VL - 61

SP - 2202

EP - 2214

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 10

ER -