MANF protects human pancreatic beta cells against stress-induced cell death

Elina Hakonen; Vikash Chandra; Christopher L. Fogarty; Nancy Yiu-Lin Yu; Jarkko Ustinov; Shintaro Katayama; Emilia Galli; Tatiana Danilova; Paivi Lindholm; Aki Vartiainen; Elisabet Einarsdottir; Kaarel Krjutskov; Juha Kere; Mart Saarma; Maria Lindahl; Timo Otonkoski

doi:10.1007/s00125-018-4687-y

MANF protects human pancreatic beta cells against stress-induced cell death

Elina Hakonen, Vikash Chandra, Christopher L. Fogarty, Nancy Yiu-Lin Yu, Jarkko Ustinov, Shintaro Katayama, Emilia Galli, Tatiana Danilova, Paivi Lindholm, Aki Vartiainen, Elisabet Einarsdottir, Kaarel Krjutskov, Juha Kere, Mart Saarma, Maria Lindahl, Timo Otonkoski

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Diabetologia
Volume	61
Issue number	10
Pages (from-to)	2202-2214
Number of pages	13
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-018-4687-y
Publication status	Published - Oct 2018
MoE publication type	A1 Journal article-refereed

Fields of Science

Beta cell proliferation
Beta cell protection
Endoplasmic reticulum stress
Mesencephalic astrocyte-derived neurotrophic factor (MANF)
NF-kappa B
NF-KAPPA-B
ENDOPLASMIC-RETICULUM STRESS
NEUROTROPHIC FACTOR MANF
DIFFERENTIAL EXPRESSION
INSULIN-SECRETION
ER STRESS
TYPE-1
PROLIFERATION
TRANSCRIPTOME
NORMALIZATION
3121 General medicine, internal medicine and other clinical medicine

Access to Document

10.1007/s00125-018-4687-y

MANF protects human pancreatic beta cellsFinal published version, 2.42 MBLicence: Other

Cite this

Hakonen, E., Chandra, V., Fogarty, C. L., Yu, N. Y-L., Ustinov, J., Katayama, S., Galli, E., Danilova, T., Lindholm, P., Vartiainen, A., Einarsdottir, E., Krjutskov, K., Kere, J., Saarma, M., Lindahl, M., & Otonkoski, T. (2018). MANF protects human pancreatic beta cells against stress-induced cell death. Diabetologia, 61(10), 2202-2214. https://doi.org/10.1007/s00125-018-4687-y

@article{c98bdb2344c2409ca2051e2700d6542a,

title = "MANF protects human pancreatic beta cells against stress-induced cell death",

keywords = "Beta cell proliferation, Beta cell protection, Endoplasmic reticulum stress, Mesencephalic astrocyte-derived neurotrophic factor (MANF), NF-kappa B, NF-KAPPA-B, ENDOPLASMIC-RETICULUM STRESS, NEUROTROPHIC FACTOR MANF, DIFFERENTIAL EXPRESSION, INSULIN-SECRETION, ER STRESS, TYPE-1, PROLIFERATION, TRANSCRIPTOME, NORMALIZATION, 3121 General medicine, internal medicine and other clinical medicine",

author = "Elina Hakonen and Vikash Chandra and Fogarty, {Christopher L.} and Yu, {Nancy Yiu-Lin} and Jarkko Ustinov and Shintaro Katayama and Emilia Galli and Tatiana Danilova and Paivi Lindholm and Aki Vartiainen and Elisabet Einarsdottir and Kaarel Krjutskov and Juha Kere and Mart Saarma and Maria Lindahl and Timo Otonkoski",

year = "2018",

month = oct,

doi = "10.1007/s00125-018-4687-y",

language = "English",

volume = "61",

pages = "2202--2214",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer",

number = "10",

}

Hakonen, E , Chandra, V, Fogarty, CL, Yu, NY-L, Ustinov, J, Katayama, S, Galli, E, Danilova, T, Lindholm, P, Vartiainen, A, Einarsdottir, E, Krjutskov, K, Kere, J , Saarma, M , Lindahl, M & Otonkoski, T 2018, 'MANF protects human pancreatic beta cells against stress-induced cell death', Diabetologia, vol. 61, no. 10, pp. 2202-2214. https://doi.org/10.1007/s00125-018-4687-y

TY - JOUR

T1 - MANF protects human pancreatic beta cells against stress-induced cell death

AU - Hakonen, Elina

AU - Chandra, Vikash

AU - Fogarty, Christopher L.

AU - Yu, Nancy Yiu-Lin

AU - Ustinov, Jarkko

AU - Katayama, Shintaro

AU - Galli, Emilia

AU - Danilova, Tatiana

AU - Lindholm, Paivi

AU - Vartiainen, Aki

AU - Einarsdottir, Elisabet

AU - Krjutskov, Kaarel

AU - Kere, Juha

AU - Saarma, Mart

AU - Lindahl, Maria

AU - Otonkoski, Timo

PY - 2018/10

Y1 - 2018/10

KW - Beta cell proliferation

KW - Beta cell protection

KW - Endoplasmic reticulum stress

KW - Mesencephalic astrocyte-derived neurotrophic factor (MANF)

KW - NF-kappa B

KW - NF-KAPPA-B

KW - ENDOPLASMIC-RETICULUM STRESS

KW - NEUROTROPHIC FACTOR MANF

KW - DIFFERENTIAL EXPRESSION

KW - INSULIN-SECRETION

KW - ER STRESS

KW - TYPE-1

KW - PROLIFERATION

KW - TRANSCRIPTOME

KW - NORMALIZATION

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1007/s00125-018-4687-y

DO - 10.1007/s00125-018-4687-y

M3 - Article

VL - 61

SP - 2202

EP - 2214

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 10

ER -